Topical Miconazole Nanogel: In Vitro Characterization, In Vivo Skin Irritation, and Enhanced Antifungal Efficacy

May 12, 2026

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This research develops a topical miconazole nanogel using a solvent diffusion approach with Carbopol 940, chitosan, and locust bean gum, supported by triethanolamine as a gelling system. The formulation is evaluated through physicochemical profiling: appearance, pH compatibility, FTIR confirmation of drug–polymer compatibility, viscosity, washability, spreadability, extrudability, drug content, entrapment efficiency, particle size, zeta potential, optical microscopy, DSC, stability, and performance assays. In vivo rat testing shows no erythema or edema at 24 h, while in vivo/skin studies demonstrate improved ex-vivo penetration and retention versus marketed gel. In vitro diffusion and antifungal testing confirm enhanced efficacy with stability.

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May 12, 2026