Fibroblast-like Synoviocytes Role in Synovial Fibrosis Associated with Osteoarthritis

Apr 17, 2026

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Fibroblast-like synoviocytes (FLS) constitute a heterogeneous synovial cell population implicated in osteoarthritis-related synovial fibrosis. Activated FLS are proposed to adopt a myofibroblast-like phenotype that drives fibrogenesis via excessive extracellular matrix deposition and increased contractile activity. This review characterizes FLS in the synovium, outlines extracellular or endogenous factors that may trigger their activation in osteoarthritis, and explains how myofibroblast-like activity reshapes synovial membrane structure.

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Fibroblast-like Synoviocytes Role in Synovial Fibrosis Associated with Osteoarthritis

Apr 17, 2026

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