Question 1

Which Cu-MOF nanocomposites are evaluated for DOX loading and pH-responsive release?

Accepted Answer

The work evaluates GO/Cu-TCPP and Fe3O4@Cu3(BTC)2 as nanocomposites for loading doxorubicin and releasing it in a pH-sensitive manner in vitro.

Question 2

How do the two nanocomposites compare in drug loading and release at different pH values?

Accepted Answer

GO/Cu-TCPP adsorbs more DOX (45.7 wt.%) than Fe3O4@Cu3(BTC)2 (40.5 wt.%). At pH 5, cumulative DOX release is 98.9% in 60 h for GO/Cu-TCPP and 85.5% for Fe3O4@Cu3(BTC)2, with much lower release at pH 7.4.

Question 3

What conclusions are drawn about toxicity and anticancer effectiveness?

Accepted Answer

Both nanocomposites show low toxicity and good biocompatibility. However, DOX-loaded GO/Cu-TCPP exhibits better toxicity toward cancer cells than DOX-loaded Fe3O4@Cu3(BTC)2.