Age-Related Acute Subjective, Behavioral, Cognitive and Cardiovascular Effects of Tetrahydrocannabinol

Sep 29, 2026

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Recreational and medical cannabis use in older adults is rising alongside legalization, yet the acute effects of cannabinoids in this population remain insufficiently studied. Older individuals may be more vulnerable to THC due to age-related changes in the endocannabinoid system, cognition, psychomotor function, postural stability, cardiovascular reserve, and drug metabolism. A controlled double-blind, placebo-controlled crossover study will present subjective, behavioral, cognitive, psychomotor, and cardiovascular responses, and examine THC pharmacokinetics across age groups.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages1

Reading Time3 min

AccessFree to download

Abstract

Study focus and rationale

Expected age-related vulnerabilities

Study design and measured outcomes

Preliminary findings and implications

FAQs

Why is the study focused on older adults and THC acute effects?

Cannabis use is increasing in older adults, and there are higher odds of cannabis-related problems in those aged 55 and above. Despite many studies in younger populations, acute cannabinoid effects in older adults are not well-studied.

What mechanisms may make older adults more vulnerable to THC?

Age-related changes may affect the endocannabinoid system (THC’s target), cognitive function, psychomotor function, postural stability, cardiovascular reserve, and drug metabolism, increasing vulnerability.

What preliminary results are reported regarding memory and anxiety in older adults?

Under THC relative to placebo, older individuals recalled fewer words than younger controls on both immediate and delayed recall, and they reported greater THC-induced anxiogenic (anxiety-producing) effects.

Sep 29, 2026

Upload by Aditya