Acute paraxanthine ingestion increases energy, focus, and satiety - enhancing postprandial cognitive performance in young adults

Q: What was the main objective of the study?

To determine whether paraxanthine can increase energy, focus, cognitive performance, and manage appetite in young healthy adults in the fed state.

Q: How was paraxanthine administered and when were outcomes measured?

Participants took 200 mg (PXN 200), 300 mg (PXN 300), or placebo 30 minutes before a mixed meal, and assessments were collected pre-ingestion and up to 180 minutes after the meal using visual analogue scales and cognitive tests.

Q: Which dose showed stronger effects on energy, productivity, focus, and satiety?

PXN 200 showed superior improvements in energy and productivity versus placebo, and it increased focus and satiety more than placebo, without affecting appetite.

Sep 30, 2026

Uploaded by Putri

Paraxanthine taken in the fed state may affect subjective energy, attention-related focus, appetite regulation, and post-meal cognitive output. A double-blind, randomized, placebo-controlled crossover study in 24 young healthy adults compared 200 mg and 300 mg paraxanthine with placebo, administered after an overnight fast and 30 minutes before a mixed meal, then measured energy, focus, productivity, satiety, appetite, and cognition over 30–180 minutes post-meal. The 200 mg dose improved energy, productivity, focus, and satiety versus placebo and enhanced N-Back engagement and accuracy, while both doses improved engagement measures.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages1

Reading Time3 min

AccessFree to download

Abstract

Background

Methods

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Acute paraxanthine ingestion increases energy, focus, and satiety, enhancing postprandial cognitive performance in young adults Sidney Abou Sawana, Ralf Jägerb,c and Raza Bashira aScientific Affairs, Iovate Health Sciences International Inc, Oakville, ON, Canada; bIncrenovo LLC, Whitefish Bay, WI, USA; cIngenious Ingredients L.P, Lewisville, TX, USA ABSTRACT Background: Paraxanthine, when ingested in doses of 50–200 mg in the fasted state, enhances cognitive performance, including memory, reaction time, and attention, while suppressing hunger. However, unlike caffeine, paraxanthines effects on energy, focus, appetite, and cognition in the fed state are unexplored. Our objective was to determine if paraxanthine can increase energy, focus, cognitive performance, and manage appetite in young healthy adults in the fed state. Methods: We conducted a double-blind, randomized, placebo-controlled, crossover study with 24 young, healthy adults (12 males, 12 females; age: 24 ± 5 years; BMI: 24.7 ± 2.3 kg/ m2). Participants consumed MuscleTech® paraxanthine at 200 mg (PXN 200), 300 mg (PXN 300), or placebo (PLA) after an overnight fast and 30 minutes before a mixed meal (340 kcal: 46 g carbs, 29.5 g protein, 6 g fat). Measures of energy, focus, productivity, satiety, and appetite were assessed using a visual analogue scale, along with cognitive performance tests (N-Back, Go/No-Go, Serial 7s), were taken at −30 minutes (pre-product ingestion), at 0 (pre-meal ingestion), and 30-, 60-, 120-, and 180-minutes post-meal. Results: Both doses of paraxanthine increased energy and productivity compared to PLA (p < 0.01), with PXN 200 showing superior effects over PXN 300 (p < 0.05) . PXN 200 also increased focus and satiety more than PLA (p < 0.005) and showed a trend over PXN 300 (p = 0.052), without affecting appetite (p = 0.53) . In cognitive tasks, PXN 200 and PXN 300 improved performance on the N-Back task by increasing engagement (p < 0.01) and correct responses (p < 0.05) compared to PLA. PXN 300 specifically reduced time per score compared to PLA (p < 0.05) and increased overall score compared to PLA (p < 0.01), while PXN 200 showed temporary enhancements at 60 and 120 minutes compared to −30 minutes (p < 0.01) . On the Go/No-Go task, PXN 300 improved Go responses compared to PLA (p < 0.05) with a trend toward better performance than PXN 200 (p = 0.056), while PXN 200 improved reaction time at 120 minutes compared to −30 minutes (p < 0.05) . No effects were observed in No-Go performance (accuracy or reaction time) or Serial 7s compared to PLA (p ≥ 0.26), indicating paraxanthine does not influence impulse control or arithmetic ability in the fed state. Conclusions: Our data suggest that paraxanthine, particularly at the 200 mg dose, can enhance subjective feelings of energy, focus, productivity, and satiety, as well as cognitive improvements in attention and processing speed in the fed state. KEYWORDS Supplement; cognition; productivity; appetite Funding This study was funded by Iovate Health Sciences International Inc and was conducted by The Center for Applied Health Sciences, Canfield, Ohio. RJ has been named as an inventor for PXN method patents. CONTACT Sidney Abou Sawan [sidney.abousawan@iovate.com](sidney.abousawan@iovate.com), Iovate Health Sciences International Inc, Oakville, ON L6M0H4, Canada © 2025 The Author(s) . Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ([http://creativecommons.org/licenses/by/4.0/](http://creativecommons.org/licenses/by/4.0/)), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

FAQs

What was the main objective of the study?

To determine whether paraxanthine can increase energy, focus, cognitive performance, and manage appetite in young healthy adults in the fed state.

How was paraxanthine administered and when were outcomes measured?

Participants took 200 mg (PXN 200), 300 mg (PXN 300), or placebo 30 minutes before a mixed meal, and assessments were collected pre-ingestion and up to 180 minutes after the meal using visual analogue scales and cognitive tests.

Which dose showed stronger effects on energy, productivity, focus, and satiety?

PXN 200 showed superior improvements in energy and productivity versus placebo, and it increased focus and satiety more than placebo, without affecting appetite.

Sep 30, 2026

Uploaded by Putri