Venous Thromboembolism Diagnosis and Management of Special Populations in Latin America - Educational Slide Sets - ASH 2022

Sep 1, 2026

Educational slide sets for the American Society of Hematology 2022 present venous thromboembolism (VTE) diagnosis and management guidance tailored to special populations in Latin America. The material outlines how Latin American recommendations were developed using the GRADE-ADOLOPMENT approach, including panel formation, PICO-framed clinical questions, and evidence synthesis across benefits, harms, feasibility, acceptability, accessibility, and patient values. It covers diagnostic pretest probability concepts and reviews comparative outcomes versus original ASH recommendations, including changes in guidance and strength.

LanguageEnglish

CategoryPresentations

FormatPPTX

Pages52

Reading Time18 min

AccessFree to download

How were the guidelines developed?

Panel formation

Clinical questions (PICO)

Evidence synthesis

Making recommendations

Methods (GRADE-ADOLOPMENT)

Objectives and diagnostic considerations

Prevalence and probability pretest

Diagnostic considerations

Results of the Latin American guidelines analysis

Changes vs original guidance

Venous Thromboembolism Diagnosis and Management of Special Populations in Latin America Educational Slide Sets American Society of Hematology 2022 for the Management of Venous Thromboembolism Disease Author: Dr Juan Carlos Serrano Casas, MD, Central University of Venezuela Clínica Cancerológica de Norte de Santander (North Santander Oncology Clinic) Clinical Practice Guidelines ASH, ABHH, ACHO, CAHT Group, CLAHT Group, SAH, SBHH, SHU, SOCHIHEM, SOMETH, Panamenian Society of Hematology, SPH, SVH. 2022 guidelines for venous thromboembolism diagnosis and management of Special Populations in Latin America Ignacio Neumann, Ariel Izcovich, Ricardo Aguilar, Guillermo León Basantes, Patricia Casais, Cecilia Colorio, Cecilia Guillermo, Pedro Garcia Lazaro, Jaime Pereira, Luis Meillon, Suely Meireles Rezende, Juan Carlos Serrano, Mario Luis Tejerina Valle, Felipe Vera, Lorena Karzulovic, Gabriel Rada, Holger Schunemann. GRADE-ADOLOPMENT is an explicit and systematic method for adoption, adaptation, or development of evidence-based recommendations derived from the existing GRADE-focused recommendation. GRADE Evidence to Decision frameworks for adoption, adaptation, and de novo development of trustworthy recommendations: GRADE-ADOLOPMENT¨ (J Clin Epidemiol. 2017 Jan; 81:101-110). Latin American ADOLOPMENT project The Latin American ADOLOPMENT project is a pilot collaborative effort of the following institutions Argentinian Society of Hematology (Sociedad Argentina de Hematología, SAH), Cecilia Colorio, MD Bolivian Society of Hematology and Hemotherapy (Sociedad Boliviana de Hematología y Hemoterapia, SBHH), Mario Luis Tejerina Valle, MD Brazilian Association of Hematology, Hemotherapy and Cellular Therapy (Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular, ABHH), Suely Meireles Rezende, MD PhD Chilean Society of Hematology (Sociedad Chilena de Hematología), Jaime Pereira, MD Peruvian Society of Hematology (Sociedad Peruana de Hematología, SPH), Pedro García Lázaro, MD Uruguay’s Society of Hematology (Sociedad de Hematología del Uruguay, SHU), Cecilia Guillermo, MD Venezuelan Society of Hematology (Sociedad Venezolana de Hematología, SVH), Juan Carlos Serrano, MD Latin American Cooperative for Hemostasis and Thrombosis (Grupo Cooperativo Latinoamericano de Hemostasis y Trombosis, CLAHT), Patricia Casais, MD Mexican Association of Hematology (Asociación Mexicana de Hematología), Luis Meillon, MD Colombian Association of Hematology and Oncology (Asociación Colombiana de Hematología y Oncología), Guillermo Basantes, MD American Society of Hematology MacGRADE Center ASH Clinical Practice Guidelines on VTE VTE prevention in surgical hospitalized patients VTE prevention in VTE prevention in medical hospitalized patients Acute VTE treatment (DVT and PE) Optimal management of anticoagulation therapy VTE prevention and treatment in cancer patients Heparin-Induced Thrombocytopenia (HIT) Thrombophilia VTE diagnosis Pediatric VTE VTE in the context of pregnancysurgical hospitalized patients How were the ASH guidelines were developed? PANEL FORMATION Each panel was formed following these key criteria: Balance of expertise (including disciplines beyond hematology, and patients) Attention to minimization and management of COI CLINICAL QUESTIONS 10 to 20 clinically-relevant questions generated in PICO format (population, intervention, comparison, and outcome) EVIDENCE SYNTHESIS Evidence analysis for each PICO question x systematic review of effects: Desirable and undesirable effects Resource use Feasibility Acceptability Accessibility Patient values and preferences PICO QUESTION EXAMPLE In a population of patients with low clinical probability of PTE, what is the best diagnostic strategy to assess a PTE hypothesis? MAKING RECOMMENDATIONS Recommendations made by panel members based on evidence for all factors ASH guidelines are reviewed annually by expert work groups convened by ASH. Resources, such as this slide set, derived from guidel

FAQs

What method supports the adaptation of evidence-based recommendations in these ASH guidelines?

The slide set emphasizes GRADE-ADOLOPMENT, an explicit method for adoption, adaptation, or development of evidence-based recommendations derived from existing GRADE-focused guidance.

How are clinical questions structured for evidence review in the guideline development process?

Clinical questions are generated in PICO format, defining the population, intervention, comparison, and outcome for systematic evidence synthesis.

How does pretest probability relate to VTE diagnosis in the recommendations?

Diagnosis relies on assessing clinical probability before tests, categorizing patients as low/intermediate/high probability or likely/unlikely, which determines expected VTE prevalence and influences the predictive value of diagnostic tests.

What changes occurred in the Latin American recommendations compared with the original ASH guidelines?

The material reports significant changes to diagnostic recommendations (2/10) and management recommendations (9/18), including both guidance and strength changes.

Sep 1, 2026

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