ICRP Publication XXX - Scientific Evidence Relevant to the Assessment of Solid Cancer Radiation Risk at Low Dose and Low Dose Rate - Final report

Sep 2, 2026

ICRP Public Consultation final report presents scientific evidence for assessing solid cancer radiation risk under low dose and low dose rate conditions. It organizes the evidence across historical concepts such as LDEF, DREF and DDREF, then evaluates mechanistic cellular radiobiology, cellular endpoints and response modulation. The report extends to animal studies, epidemiological data focusing on low-dose-rate and low-dose effects, and analyses of dose-response shape and curvature. It further reviews biologically motivated mechanistic models to support risk assessment frameworks.

LanguageEnglish

CategoryPresentations

FormatDOCX

Pages129

Reading Time45 min

AccessFree to download

Abstract

MAIN POINTS

EXECUTIVE SUMMARY

1. INTRODUCTION

1.1. Background

1.2. Scope and objective

1.3. Structure of this publication

2. HISTORICAL DEVELOPMENT

2.1. Definition of LDEF, DREF, and DDREF

2.2. Positions of National and International Organisations – Historical Context

2.3. Selected Recent Relevant Publications

2.4. Conclusions

3. CELLULAR RADIOBIOLOGICAL STUDIES

3.1. Identifying mechanisms and cellular endpoints relevant for studying LDEF and DREF

3.2. Consideration of specific endpoints

3.3. Effects of low dose and dose rate – should they be considered together?

3.4. Modulation of responses to radiation

3.5. Conclusion

ICRP ref: 4904-3744-8231 Annals of the ICRP ICRP PUBLICATION XXX Scientific Evidence Relevant to the Assessment of Solid Cancer Radiation Risk at Low Dose and Low Dose Rate Editor-in-Chief C.H. CLEMENT Associate Editor K. NAKAMURA Authors on behalf of ICRP xxx PUBLISHED FOR The International Commission on Radiological Protection by INCLUDEPICTURE "https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png" \* MERGEFORMATINET INCLUDEPICTURE "https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png" \* MERGEFORMATINET INCLUDEPICTURE "https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png" \* MERGEFORMATINET INCLUDEPICTURE "https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png" \* MERGEFORMATINET INCLUDEPICTURE "https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png" \* MERGEFORMATINET INCLUDEPICTURE "https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png" \* MERGEFORMATINET INCLUDEPICTURE "https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png" \* MERGEFORMATINET INCLUDEPICTURE "https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png" \* MERGEFORMATINET INCLUDEPICTURE "https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png" \* MERGEFORMATINET INCLUDEPICTURE "https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png" \* MERGEFORMATINET INCLUDEPICTURE "https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png" \* MERGEFORMATINET INCLUDEPICTURE "https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png" \* MERGEFORMATINET INCLUDEPICTURE "https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png" \* MERGEFORMATINET INCLUDEPICTURE "https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png" \* MERGEFORMATINET INCLUDEPICTURE "https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png" \* MERGEFORMATINET INCLUDEPICTURE "https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png" \* MERGEFORMATINET INCLUDEPICTURE "https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png" \* MERGEFORMATINET INCLUDEPICTURE "https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png" \* MERGEFORMATINET INCLUDEPICTURE "https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png" \* MERGEFORMATINET INCLUDEPICTURE "https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png" \* MERGEFORMATINET INCLUDEPICTURE "https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png" \* MERGEFORMATINET INCLUDEPICTURE "https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png" \* MERGEFORMATINET INCLUDEPICTURE "https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png" \* MERGEFORMATINET INCLUDEPICTURE "https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png" \* MERGEFORMATINET INCLUDEPICTURE "https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png" \* MERGEFORMATINET INCLUDEPICTURE "https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png" \* MERGEFORMATINET INCLUDEPICTURE "https://home.heinonline.org/wp-content/uploads/2020/09/SAGE_Logo.png" \* MERGEFORMATINET Please cite this issue as ‘ICRP, 20xx. Scientific evidence relevant to the assessment of solid cancer radiation risk at low dose and low dose rate. ICRP Publication XXX. Ann. ICRP xx(x).’ CONTENTS TOC \o "1-2" \u Abstract PAGEREF _Toc191912770 \h 4 MAIN POINTS PAGEREF _Toc191912771 \h 5 EXECUTIVE SUMMARY PAGEREF _Toc191912772 \h 6 1. INTRODUCTION PAGEREF _Toc191912773 \h 9 1.1. Background PAGEREF _Toc191912774 \h 9 1.2. Scope and objective PAGEREF _Toc191912775 \h 13 1.3. Structure of this publication PAGEREF _Toc191912776 \h 14 2. HISTORICAL DEVELOPMENT PAGEREF _Toc191912777 \h 16 2.1. Definition of LDEF, DREF, and DDREF PAGEREF _Toc191912778 \h 1

FAQs

What radiation conditions does this publication address for solid cancer risk assessment?

It focuses on low dose and low dose rate conditions relevant to the assessment of solid cancer radiation risk.

Which historical concepts are defined in the report?

The report defines LDEF, DREF, and DDREF, and discusses their development through national and international perspectives.

How is the evidence organized beyond history and concepts?

The publication reviews cellular radiobiological studies, animal studies, epidemiological evidence (low-dose-rate and low-dose effects), and studies using biologically motivated mechanistic models.

Sep 2, 2026

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