Allergy Diagnostic Testing: An Updated Practice Parameter - Practice Parameter - Volume 100 - Number 3 - Supplement 3

Oct 12, 2026

Uploaded by Ben

Allergy Diagnostic Testing: An Updated Practice Parameter (March 2008; Volume 100, Number 3, Supplement 3) presents evidence-based recommendations for allergy diagnostic practice. It emphasizes how technological refinements and their validations from the prior decade are incorporated into allergists/clinical immunologists’ diagnostic tools to confirm human clinical sensitivity. The document defines “allergy” as major categories of human hypersensitivity, outlines scope focused on adaptive immunity, and updates prior 1988 and 1995 practice parameters by integrating an expanded research database while aiming for balanced use of classic and newer diagnostic methods.

LanguageEnglish

CategoryGeneral

FormatPDF

Pages149

Reading Time52 min

AccessFree to download

Preface

Executive Summary

Collation of Summary Statements

Part 1

In Vivo Diagnostic Tests of Immediate Hypersensitivity Reactions

Organ Challenge Tests

Tests to Distinguish Clinical Obstructive Diseases Resembling Asthma

In Vivo Diagnostic Tests of Cell-Mediated Immunity

In Vitro Diagnostic Tests of Immediate Hypersensitivity

In Vitro Diagnostic Tests of Cell-Mediated Immunity

Other Diagnostic Immunologic Tests

Unproven Tests

Part 2

Allergens

Assessment of Inhalant Allergy

Assessment of Food Allergy

Assessment of Stinging Insect Allergy

Assessment of Drug Allergy

Assessment of Allergic Contact Dermatitis

Acknowledgments

References

ANNALS OF ALLERGY, ASTHMA, & IMMUNOLOGY March 2008; Volume 100, Number 3, Supplement 3 Allergy Diagnostic Testing: An Updated Practice Parameter Practice Parameter Allergy Diagnostic Testing: An Updated Practice Parameter I. Leonard Bernstein, MD; James T. Li, MD, PhD; David I. Bernstein, MD; Robert Hamilton, PhD, DABMLI; Sheldon L. Spector, MD; Ricardo Tan, MD; Scott Sicherer, MD; David B. K. Golden, MD; David A. Khan, MD; Richard A. Nicklas, MD; Jay M. Portnoy, MD; Joann Blessing-Moore, MD; Linda Cox, MD; David M. Lang, MD; John Oppenheimer, MD; Christopher C. Randolph, MD; Diane E. Schuller, MD; Stephen A. Tilles, MD; Dana V. Wallace, MD; Estelle Levetin, PhD; and Richard Weber, MD TABLE OF CONTENTS I. Preface .................................................................................... S2 II. Executive Summary ......................................................................... S3 III. Collation of Summary Statements .............................................................. S5 IV. Part 1 .................................................................................... S 15 V. In Vivo Diagnostic Tests of Immediate Hypersensitivity Reactions .................................. S 15 VI. Organ Challenge Tests ...................................................................... S29 VII. Tests to Distinguish Clinical Obstructive Diseases Resembling Asthma ............................... S33 VIII. In Vivo Diagnostic Tests of Cell-Mediated Immunity ............................................. S34 IX. In Vitro Diagnostic Tests of Immediate Hypersensitivity ........................................... S43 X. In Vitro Diagnostic Tests of Cell-Mediated Immunity ............................................. S59 XI. Other Diagnostic Immunologic Tests ........................................................... S64 XII. Unproven Tests ............................................................................ S65 XIII. Part 2 .................................................................................... S66 XIV. Allergens ................................................................................. S67 XV. Assessment of Inhalant Allergy ............................................................... S74 XVI. Assessment of Food Allergy................................................................. S 102 XVII. Assessment of Stinging Insect Allergy ........................................................ S 106 XVIII. Assessment of Drug Allergy................................................................. S 109 XIX. Assessment of Allergic Contact Dermatitis ..................................................... S 115 XX. Acknowledgments ......................................................................... S 121 XXI. References ............................................................................... S 122 The American Academy of Allergy, Asthma and Immunology (AAAAI) and the American College of Allergy, Asthma and Immunology (ACAAI) have jointly accepted responsibility for establishing the Allergy Diagnostic Testing: An Updated Practice Parameter. This is a complete and comprehensive document at the current time. The medical environment is a changing environment and not all recommendations will be appropriate for all patients. Because this document incorporated the efforts of many participants, no single individual, including those who served on the Joint Task Force, is authorized to provide an official AAAAI or ACAAI interpretation of these practice parameters. Any request for information about or an interpretation of these practice parameters by the AAAAI or ACAAI should be directed to the Executive Offices of the AAAAI, the ACAAI, and the Joint Council of Allergy, Asthma and Immunology. These parameters are not designed for use by pharmaceutical companies in drug promotion. Received for publication October 27, 2007; Accepted for

FAQs

What is the main purpose of this updated practice parameter?

It focuses on incorporating technological refinements validated over the past decade into allergy diagnostic practice to confirm human clinical sensitivity and provide updated evidence-based recommendations.

How does the document define “allergy” for its scope?

It defines “allergy” as major categories of human hypersensitivity, emphasizing pertinent clinical immunologic techniques oriented to adaptive immunity rather than infection, cancer, or transplantation immunology.

Why was the 1995 allergy diagnostic parameter updated?

The document explains that major advances in basic and translational immunologic research since 1995 created the need for an overhaul, using an expanded database to achieve balanced use of classic and newer diagnostic methods.

Oct 12, 2026

Uploaded by Ben