World Journal of Clinical Oncology - Original Article - Retrospective Study - Stem cell collection from peripheral blood of multiple myeloma patients

Sep 28, 2026

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BACKGROUND: The paper presents a practical stem cell collection approach that yields sufficient cells for autologous stem cell transplantation (ASCT) in multiple myeloma patients even when peripheral CD34 counts are low. It also outlines benefits for patients with limited resources. AIM: Demonstrate a practical stem cell collection method. METHODS: Stem cell collection data from the last 300 patients at a community cancer center in Washington were reviewed, reporting collection methods, medications, timing, and outcomes. RESULTS and CONCLUSION support feasibility by routinely adding plerixafor to G-CSF on day 4.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages9

Reading Time23 min

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Abstract

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| W | J | C | O | World Journal of
Clinical Oncology | | --- | --- | --- | --- | --- | Submit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Clin Oncol 2025 December 24; 16(12): 103683 DOI: 10.5306/wjco.v16.i12.103683 ISSN 2218-4333 (online) ORIGINAL ARTICLE Retrospective Study Stem cell collection from peripheral blood of multiple myeloma patients Jonah Lee, Quincy Seigel, Spencer Lee, Emily Green, Sara Chitlik, Veronika Lobova, Paul Eastvold, Chris Gresens, Erin A Kaya Specialty type: Oncology Provenance and peer review: Unsolicited article; Externally peer reviewed. Peer-review model: Single blind Peer-review report’s classification Scientific Quality: Grade B Novelty: Grade A Creativity or Innovation: Grade A Scientific Significance: Grade A P-Reviewer: Lin JY, MD, PhD, United States Received: November 28, 2024 Revised: March 9, 2025 Accepted: November 14, 2025 Published online: December 24, 2025 Processing time: 391 Days and 2.2 Hours Jonah Lee, Spencer Lee, Department of Radiation Oncology, Cancer Care Northwest, Spokane, WA 99204, United States Quincy Seigel, Department of Internal Medicine, University of Texas Medical Branch at Galveston, Galveston, TX 77555, United States Emily Green, College of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, United States Sara Chitlik, College of Medicine, Rush Medical College, Chicago, IL 60612, United States Veronika Lobova, General Surgery, UCSF Fresno Surgery, Fresno, CA 93701, United States Paul Eastvold, Chris Gresens, Blood Center, Vitalant Blood Centers, Spokane, WA 99201, United States Erin A Kaya, Department of Radiation Oncology, Oregon Health Sciences University, Portland, OR 97239, United States Corresponding author: Erin A Kaya, MD, Department of Radiation Oncology, Oregon Health Sciences University, 3181 S.W. Sam Jackson Park Road, Portland, OR 97239, United States. [erinkaya@berkeley.edu](erinkaya@berkeley.edu) Abstract BACKGROUND The purpose of this paper is to demonstrate a practical stem cell collection method that provides sufficient stem cells for autologous stem cell transplantation (ASCT) in multiple myeloma (MM) patients despite low peripheral CD34 (pCD34) countsand to describe the benefits of this method for MM patients with limited resources. AIM To demonstrate a practical method for stem cell collection. METHODS Stem cell collection data on the last 300 patients at a community cancer center in Washington were reviewed. We report on the methods of collection, including medi-cations used and timing, used by the blood blank as well as their outcomes. WJCO [https://www.wjgnet.com](https://www.wjgnet.com) 1 December 24, 2025 Volume 16 Issue 12 Lee J et al. Successful stem cell collection low CD34 The three MM patients with initially very low pCD34 counts all successfully underwent stem cell collection in a single trip to the transplant center for their ASCT. RESULTS Three patients whose pre-collection pCD34 counts were the lowest and less than 2.5 cells/μL were identified. These patients had the commonality of having multiple barriers to transportation and likely would have been able to make only one trip for the stem cell collections. CONCLUSION Despite particularly low pre-collection peripheral blood CD34 counts, successful autologous stem cell collection in MM patients is feasible by routinely adding plerixafor to granulocyte-colony stimulating factor on day 4 of mobilization. There is limited analysis demonstrating that sufficient stem cells for one or more transplants can be collected using this method. This practical and novel approach may benefit the high number of MM patients who face limited resources, finances, long travel times, and social support. These results are highly relevant to physicians treating similar patients. Key Words: Multiple myeloma; Stem cell collection; Plerixafor; Peripheral CD43

FAQs

What is the main purpose of the study?

To demonstrate a practical stem cell collection method that provides enough stem cells for autologous stem cell transplantation in multiple myeloma patients despite low peripheral CD34 counts, and to describe its benefits for patients with limited resources.

How were the study data collected and analyzed?

Stem cell collection data from the last 300 patients at a community cancer center in Washington were reviewed, including collection methods, medications used, timing, and outcomes.

What intervention is recommended for low peripheral CD34 counts?

Routinely adding plerixafor to granulocyte-colony stimulating factor on day 4 of mobilization to enable successful autologous stem cell collection even with very low peripheral CD34.

Sep 28, 2026

Uploaded by Fahsai