Updated European guidelines for clinical management of familial adenomatous polyposis (FAP) - MUTYH-associated polyposis (MAP) - joint EHTG-ESCP revision

Sep 21, 2026

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Updated European guidelines provide joint EHTG-ESCP recommendations for clinical management of familial adenomatous polyposis (FAP) and MUTYH-associated polyposis (MAP), including related rare adenomatous polyposis syndromes. The guideline also addresses gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS). Authored by a multi-institution European collaboration, it incorporates an evidence-based revision process with dated receipt, revision, and acceptance milestones. Published as an Open Access article by Oxford University Press on behalf of BJS Foundation Ltd under a CC BY-NC 4.0 license.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages71

Reading Time2 h 59 min

AccessFree to download

BJS, 2024, znae070 [https://doi.org/10.1093/bjs/znae070](https://doi.org/10.1093/bjs/znae070) Guideline Updated European guidelines for clinical management of familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), gastric adenocarcinoma, proximal polyposis ofthe stomach (GAPPS) and other rare adenomatous polyposis syndromes: a joint EHTG-ESCP revision Gloria Zaffaroni1,2,†, Alessandro Mannucci3,† , Laura Koskenvuo4 , Borja de Lacy5 , Anna Maffioli2,6, Tanya Bisseling7, Elizabeth Half8, Giulia Martina Cavestro3 , Laura Valle9,10, Neil Ryan11, Stefan Aretz12, Karen Brown13, Francesco Buttitta14,15, Fatima Carneiro16, Oonagh Claber17, Ruth Blanco-Colino18,19, Maxime Collard20 , Emma Crosbie21, Miguel Cunha22, Triantafyllos Doulias23,24,25, Christina Fleming26, Henriette Heinrich27, Robert Hüneburg28,29, Julie Metras20, Iris Nagtegaal30, Ionut Negoi31 , Maartje Nielsen32 , Gianluca Pellino18,19,33 , Luigi Ricciardiello14,15, Abdurrahman Sagir1, Luis Sánchez-Guillén34,35 , Toni T. Seppälä4,36,37,38, Peter Siersema7, Benedikt Striebeck39, Julian R. Sampson40, Andrew Latchford41,42, Yann Parc20, John Burn43 and Gabriela Möslein1,* 1Center for Hereditary Tumors, Bethesda Hospital, Duisburg, Germany 2Faculty of Medicine and Surgery, University of Milan, Milan, Italy 3Gastroenterology and Gastrointestinal Endoscopy Unit, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milan, Italy 4Department of Gastroenterological Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland 5Department of Gastrointestinal Surgery, Hospital Clinic of Barcelona, Barcelona, Spain 6Department of General Surgery, Sacco Hospital, ASST Fatebenefratelli Sacco, Milan, Italy 7Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands 8Cancer Prevention and Hereditary GI Cancer Unit, Rambam Health Care Campus, Haifa, Israel 9Hereditary Cancer Program, Catalan Institute of Oncology, Oncobell Program, IDIBELL, Barcelona, Spain 10Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain 11The College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, UK 12Institute of Human, Genetics, Medical Faculty, University ofBonn and National Center for Hereditary Tumour Syndromes, University Hospital Bonn, Bonn, Germany 13Leicester Cancer Research Centre, University of Leicester, Leicester, UK 14Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy 15IRCCS University Hospital of Bologna, Policlinico di Sant’Orsola, Bologna, Italy 16Faculty of Medicine of Porto University, Centro Hospitalar Universitário de São João, Ipatimup, Porto, Portugal 17Department of Clinical Genetics, Northern Genetics Service, Newcastle upon Tyne, UK 18Department of Gastrointestinal Surgery, Vall d’Hebron University Hospital, Barcelona, Spain 19Universitat Autònoma de Barcelona, Barcelona, Spain 20Department of Digestive Surgery, Hôpital Saint-Antoine, Sorbonne University, APHP, Paris, France 21Division of Cancer Sciences, University of Manchester, Manchester, UK 22Department of Surgery, Algarve Universitary Hospital Center, Colorectal SurgeryGroup, Portimao, Portugal 23Department of Colorectal Surgery, Colchester Hospital, East Suffolk and North Essex NHS Foundation Trust, Colchester, UK 24Colorectal Surgery Department, Kettering Hospital, University Hospitals of Northamptonshire, Kettering, Northamptonshire, UK 25Department of Genetics and Genome Biology, Honorary Lecturer in the Leicester Cancer Research Centre, Leicester, UK 26Department of Colorectal Surgery, University Hospital Limerick, Limerick, Ireland 27Department for Gastroenterology and Hepatology, Clarunis Universitäres Bauchzentrum, Universitätsspital Basel, Basel, Switzerland 28Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany 29National Center for Hereditary Tumour Syndromes, Univer

FAQs

Which conditions are covered by the updated European guidelines?

The guidelines cover familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), gastric adenocarcinoma, proximal polyposis of the stomach (GAPPS), and other rare adenomatous polyposis syndromes.

What revision group created this guideline update?

The update is a joint EHTG-ESCP revision.

Under what access and license terms is the article published?

It is published Open Access under a Creative Commons Attribution-NonCommercial license (CC BY-NC 4.0).

Sep 21, 2026

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