Updated disease distributions, risk factors, and trends of laryngeal cancer - a global analysis of cancer registries - prospective cohort study

Sep 21, 2026

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A prospective cohort epidemiology study investigates updated global patterns of laryngeal cancer incidence and mortality and evaluates major associated risk factors. Incidence and mortality estimates are drawn from multiple international cancer registry and health databases, and temporal changes are quantified using Joinpoint regression. Worldwide incidence and mortality are reported as age-standardised rates of 2.0 and 1.0 per 100,000, with higher burdens in the Caribbean and Central/Eastern Europe. Overall incidence declines, while female and younger groups show increasing incidence. Tobacco and alcohol reductions likely contribute to declining trends, whereas mortality disparities may reflect differences in access to surgical care.

LanguageEnglish

CategoryResearch & Report

FormatPDF

Pages10

Reading Time25 min

AccessFree to download

Background

Materials and methods

Results

Conclusions

Introduction

’Prospective Cohort Study Updated disease distributions, risk factors, and trends of laryngeal cancer: a global analysis of cancer registries Junjie Huang, PhDa,b , Sze Chai Chan, MSca , Samantha Ko, GDipPsychAdva , Veeleah Lok, MPHh , Lin Zhang, PhDd,i , Xu Lin, MD, PhDc , Don Eliseo Lucero-Prisno III, PhDg , Wanghong Xu, PhDe , Zhi-Jie Zheng, MD, PhDf, Edmar Elcarte, MAj , Mellissa Withers, PhDk , Martin CS Wong, MD, MPHa,b,f,* Background: Though the laryngeal cancer only has 1% of the total cancer cases and related deaths, it is a type of head and neck cancers with the highest prevalence. This study aims to investigate the epidemiological trend of laryngeal cancer with updated data on the global distribution of the disease burden. Materials and methods: The incidence and mortality rate of laryngeal cancer was extracted from GLOBOCAN (2020), Cancer Incidence in Five Continents series I-X, WHO mortality database, the Nordic Cancer Registries, and the Surveillance, Epidemiology, and End Results Program. The Global Health data exchanges for the prevalence of its associated risk factors. A Joinpoint regression analysis was used to calculate Average Annual Percentage Change (AAPC) . Results: The age-standardised rate (ASR) of laryngeal cancer incidence and mortality were 2 .0 and 1 .0 per 100 000 worldwide. The Caribbean (ASR = 4.0) and Central and Eastern Europe (ASR = 3.6) had the highest incidence and mortality rate. Incidence and risk factors associated with laryngeal cancer included tobacco usage, alcohol consumption, poor diet, obesity, diabetes, hypertension, and lipid disorders. There was an overall decreasing trend in incidence, especially for males, but an increasing incidence was observed in female populations and younger subjects. Conclusions: As overall global trends of laryngeal cancer have been decreasing, especially for the male population, this could possibly be attributed to reduced tobacco use and alcohol consumption. Decrease in mortality may be due to improved diagnostic methods and accessibility to treatment, yet disparity in trend remains potentially because of differences in the level of access to surgical care. Disparities in temporal trends across countries may require further research and exploration to determine other underlying factors inﬂuencing this. Keywords: laryngeal cancer, incidence, mortality, risk factors, temporal trend Introduction Laryngeal cancer is one of the most prevalent types of head and neck cancers although it only accounts for around 1% of total cancer cases and related deaths[1] . Laryngeal cancer can be subdivided into subglottic, glottic, and supraglottic cancer, while its most common histological type is squamous cell carcinoma, beginning on the mucosal surface of the larynx[2] . The prognosis of laryngeal cancer is largely dependent on the timing of detection: for cases diagnosed and treated before the cancer has spread outside the larynx, the 5-year survival rate is ~80%[3] . aThe Jockey Club School of Public Health and Primary Care, bCentre for Health Education and Health Promotion, Faculty of Medicine, The Chinese University of Hong Kong, cDepartment of Thoracic Surgery, The First Afﬁliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, dSuzhou Industrial Park Monash Research Institute of Science and Technology, Suzhou, eSchool of Public Health, Fudan University, Shanghai, fDepartment of Global Health, School of Public Health, Peking University, Beijing, People’s Republic of China, gDepartment of Global Health and Development, London School of Hygiene and Tropical Medicine, London, United Kingdom, hDepartment of Global Public Health, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, iThe School of Public Health and Preventive Medicine, Monash University, Victoria, Australia, jUniversity of the Philippines, Manila, The Philippines and kDepartment of Population and Health Sciences, Institute for Global Heal

FAQs

What is the main purpose of this study on laryngeal cancer?

To investigate epidemiological trends of laryngeal cancer using updated global data on disease burden distribution.

Which data sources were used to obtain incidence and mortality rates?

Incidence and mortality were extracted from GLOBOCAN 2020, Cancer Incidence in Five Continents series I–X, WHO mortality databases, Nordic Cancer Registries, and SEER.

What trends in incidence and mortality were observed across populations?

Overall incidence showed a decreasing trend, especially in males, but incidence increased in female populations and younger subjects; mortality decreased overall though disparities remained by country.

Sep 21, 2026

Uploaded by Patrick