Unraveling the Intricate Link - Deciphering the Role of the Golgi Apparatus in Breast Cancer Progression

Sep 24, 2026

Uploaded by McQueen

Breast cancer represents a major global health burden, driving continued investigation into molecular mechanisms that shape disease progression and enable more precise diagnostics and tailored therapies. The review synthesizes evidence that alterations in Golgi apparatus function and organization may contribute to breast cancer pathogenesis. It analyzes how impaired protein glycosylation, disrupted protein transport, and abnormal oncoprotein processing influence cancer cell behavior. It further explores how Golgi-mediated secretory routes support the release of pro-tumorigenic factors during tumor evolution. Clarifying this interplay can inform innovative therapeutic strategies and biomarker discovery.

LanguageEnglish

CategoryHealthcare

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Pages13

Reading Time33 min

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Introduction

Review Unraveling the Intricate Link: Deciphering the Role of the Golgi Apparatus in Breast Cancer Progression Adrian Vasile Dumitru 1,2, Evelina-Elena Stoica 3,*, Razvan-Adrian Covache-Busuioc 4,*, Bogdan-Gabriel Bratu 4 and Monica-Mihaela Cirstoiu 3,5 Citation: Dumitru, A.V.; Stoica, E.-E.; Covache-Busuioc, R.-A.; Bratu, B.-G.; Cirstoiu, M.-M. Unraveling the Intricate Link: Deciphering the Role of the Golgi Apparatus in Breast Cancer Progression. Int. J. Mol. Sci. 2023, 24, 14073. [https://doi.org/](https://doi.org/)[ ](https://doi.org/)[10.3390/ijms241814073](10.3390/ijms241814073) Academic Editor: Anna Kawiak Received: 23 August 2023 Revised: 11 September 2023 Accepted: 13 September 2023 Published: 14 September 2023 Copyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) . 1 Department of Pathology,“Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania; [vasile.dumitru@umfcd.ro](vasile.dumitru@umfcd.ro) 2 Department of Pathology, University Emergency Hospital, 050098 Bucharest, Romania 3 Department of Obstetrics and Gynaecology, University Emergency Hospital, 050098 Bucharest, Romania; [monica.cirstoiu@umfcd.ro](monica.cirstoiu@umfcd.ro) 4 Department of Neurosurgery,“Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania; [bogdan.bratu@stud.umfcd.ro](bogdan.bratu@stud.umfcd.ro) 5 Department of Obstetrics and Gynaecology,“Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania * Correspondence: [evelina.almajanu@gmail.com](evelina.almajanu@gmail.com) (E.-E.S.); [razvan-adrian.covache-busuioc0720@stud.umfcd.ro](razvan-adrian.covache-busuioc0720@stud.umfcd.ro) (R.-A.C.-B.) Abstract: Breast cancer represents a paramount global health challenge, warranting intensiﬁed exploration of the molecular underpinnings inﬂuencing its progression to facilitate the development of precise diagnostic instruments and customized therapeutic regimens. Historically, the Golgi apparatus has been acknowledged for its primary role in protein sorting and trafﬁcking within cellular contexts. However, recent ﬁndings suggest a potential link between modiﬁcations in Golgi apparatus function and organization and the pathogenesis of breast cancer. This review delivers an exhaustive analysis of this correlation. Speciﬁcally, we examine the consequences of disrupted protein glycosylation, compromised protein transport, and inappropriate oncoprotein processing on breast cancer cell dynamics. Furthermore, we delve into the impacts of Golgi-mediated secretory routes on the release of pro-tumorigenic factors during the course of breast cancer evolution. Elucidating the nuanced interplay between the Golgi apparatus and breast cancer can pave the way for innovative therapeutic interventions and the discovery of biomarkers, potentially enhancing the diagnostic, prognostic, and therapeutic paradigms for afﬂicted patients. The advancement of such research could substantially expedite the realization of these objectives. Keywords: golgi apparatus; breast cancer; protein glycosylation; protein trafficking; cancer progression; tumor microenvironment; biomarkers therapeutic targets 1. Introduction Camillo Golgi is credited with the identiﬁcation of the Golgi apparatus, a fundamental organelle inherent to eukaryotic cells [1] . Characterized by its intricate and dynamic nature, the Golgi apparatus is pivotal in an array of cellular activities, predominantly protein modiﬁcation, segregation, conveyance, and packaging before its designated delivery to speciﬁc intracellular locales. Structurally, the organelle comprises overlapping membranous sacs, termed cisternae, which p

FAQs

What is the central focus of the review?

The review explains the relationship between Golgi apparatus function and organization and breast cancer progression, emphasizing how Golgi-related processes may influence tumor development.

Which Golgi-related mechanisms are highlighted as important for breast cancer progression?

It focuses on disrupted protein glycosylation, impaired protein transport, and inappropriate oncoprotein processing that can affect breast cancer cell dynamics.

How does the review connect the Golgi apparatus to tumor evolution and potential therapies?

It discusses how Golgi-mediated secretory routes can release pro-tumorigenic factors, and it argues that understanding these interactions may enable new therapeutic interventions and biomarker discovery.

Sep 24, 2026

Uploaded by McQueen