Two neurostructural subtypes - results of machine learning on brain images from schizophrenia - 4291 individuals

Aug 5, 2026

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Machine learning analysis identifies two neurostructural subtypes in brain imaging data from 4,291 individuals with schizophrenia. The work evaluates neuroanatomical variation associated with subgroup structure, aiming to characterize distinct patterns of brain organization relevant to heterogeneity in schizophrenia. Results summarize how model-derived clustering relates to neuroimaging features, providing evidence for clinically meaningful differentiation rather than a single uniform disease phenotype. The study is presented as a medRxiv preprint.

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UC Irvine UC Irvine Previously Published Works Title Two neurostructural subtypes: results of machine learning on brain images from 4,291 individuals with schizophrenia Permalink [https://escholarship.org/uc/item/049230gd](https://escholarship.org/uc/item/049230gd) Journal medRxiv, 4(10-23) Authors Jiang, Yuchao Luo, Cheng Wang, Jijunet al. Publication Date 2023-10-12 DOI 10.1101/2023.10.11.23296862 Copyright Information This work is made available under the terms of a Creative Commons AttributionNonCommercial-NoDerivatives License, available at [https://creativecommons.org/licenses/by-nc-nd/4.0/](https://creativecommons.org/licenses/by-nc-nd/4.0/) Peer reviewed [eScholarship.org](eScholarship.org) Powered by the California Digital Library University of California medRxiv preprint doi: [https://doi.org/10.1101/2023.10.11.23296862](https://doi.org/10.1101/2023.10.11.23296862); this version posted October 12, 2023. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license . 1 Two neurostructural subtypes: results of machine learning on brain 2 images from 4,291 individuals with schizophrenia 3 4 Yuchao Jiang1,2 , Cheng Luo3,4,5, Jijun Wang6 , Lena Palaniyappan7 , Xiao Chang1,2 , Shitong Xiang1,2 , Jie 5 Zhang1,2 , Mingjun Duan3 , Huan Huang3 , Christian Gaser8,9,10 , Kiyotaka Nemoto11 , Kenichiro Miura12 , 6 Ryota Hashimoto12 , Lars T. Westlye13,14,15 , Genevieve Richard13,14,15 , Sara Fernandez-Cabello13,14,15 , 7 Nadine Parker14 , Ole A. Andreassen14 , Tilo Kircher16 , Igor Nenadić16 , Frederike Stein16 , Florian Thomas- 8 Odenthal16 , Lea Teutenberg16 , Paula Usemann16 , Udo Dannlowski17 , Tim Hahn17 , Dominik Grotegerd17 , 9 Susanne Meinert17 , Rebekka Lencer17,68,69, Yingying Tang6, Tianhong Zhang6 , Chunbo Li6 , Weihua 10 Yue18,19,20, Yuyanan Zhang18 , Xin Yu18 , Enpeng Zhou18 , Ching-Po Lin21 , Shih-Jen Tsai22 , Amanda L. 11 Rodrigue23 , David Glahn23 , Godfrey Pearlson24 , John Blangero25 , Andriana Karuk26,27 , Edith Pomarol- 12 Clotet26,27 , Raymond Salvador26,27 , Paola Fuentes-Claramonte26,27 , María Ángeles Garcia-León26,27 , 13 Gianfranco Spalletta28 , Fabrizio Piras28 , Daniela Vecchio28 , Nerisa Banaj28, Jingliang Cheng29 , Zhening 14 Liu30 , Jie Yang30 , Ali Saffet Gonul31 , Ozgul Uslu32 , Birce Begum Burhanoglu32 , Aslihan Uyar Demir31 , 15 Kelly Rootes-Murdy33 , Vince D. Calhoun33 , Kang Sim34,35,36 , Melissa Green37 , Yann Quidé38, Young Chul 16 Chung39,40,41 , Woo-Sung Kim39,41 , Scott R. Sponheim42,43,44 , Caroline Demro43 , Ian S. Ramsay43 , Felice 17 Iasevoli45 , Andrea de Bartolomeis45 , Annarita Barone45 , Mariateresa Ciccarelli45 , Arturo Brunetti46 , Sirio 18 Cocozza46 , Giuseppe Pontillo46 , Mario Tranfa46 , Min Tae M. Park47,48 , Matthias Kirschner49,50 , Foivos 19 Georgiadis50 , Stefan Kaiser49 , Tamsyn E Van Rheenen51,52 , Susan L Rossell52 , Matthew Hughes52 , 20 William Woods52 , Sean P Carruthers52 , Philip Sumner52 , Elysha Ringin53 , Filip Spaniel53 , Antonin 21 Skoch53,54 , David Tomecek53,55,56 , Philipp Homan57,58 , Stephanie Homan59,60 , Wolfgang Omlor57 , 22 Giacomo Cecere57 , Dana D Nguyen61 , Adrian Preda62 , Sophia Thomopoulos63 , Neda Jahanshad63 , 23 Long-Biao Cui64 , Dezhong Yao3,4,5 , Paul M. Thompson63 , Jessica A. Turner65 , Theo G. M. van Erp66,67 , 24 Wei Cheng1,2,70,71,72 , ENIGMA Schizophrenia Consortium, ZIB Consortium, Jianfeng Feng1,2,72,73,74,75,76,* 25 26 1 Institute of Science and Technology for Brain Inspired Intelligence, Fudan University, Shanghai, China. 27 2 Key Laboratory of Computational Neuroscience and Brain Inspired Intelligence (Fudan University), 28 Ministry of Education, Shanghai, China. 29 3 The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformati

FAQs

What is the document’s main research topic?

It reports two neurostructural subtypes derived from machine learning applied to brain images in schizophrenia.

How many individuals are included in the machine learning analysis?

The document specifies results based on 4,291 individuals with schizophrenia.

What publication platform and licensing are associated with this work?

The document is a medRxiv preprint and is released under a CC-BY-NC-ND 4.0 International license, with a note that it is not certified by peer review.

Aug 5, 2026

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