Trends in genitourinary cancer mortality in the United States - analysis of the CDC-WONDER database 1999-2020

Q: Which cancers and years are analyzed in the study?

The study examines prostate, bladder, kidney, and testicular cancers using mortality data from the CDC WONDER database covering 1999–2020.

Q: What statistical approach is used for mortality trends?

Age-adjusted mortality rates are analyzed by year, gender, race, urban–rural status, and geographic region with a significance threshold of p < 0.05.

Q: What overall pattern is observed in mortality trends?

Age-adjusted mortality rates decline significantly for prostate, bladder, and kidney cancers, while testicular cancer-related mortality remains stable.

Sep 21, 2026

Uploaded by Maeve

Sociodemographic disparities in mortality from genitourinary cancers in the United States have not been comprehensively examined across multiple cancer types. This study analyzes gender, racial, and geographic differences in age-adjusted mortality rates for prostate, bladder, kidney, and testicular cancers using CDC WONDER data from 1999 to 2020. Results show significant declines for prostate, bladder, and kidney cancer mortality, while testicular cancer mortality remains stable. Marked differences persist by sex, race, and urban–rural status, underscoring the need for targeted interventions and further research.

LanguageEnglish

CategoryResearch & Report

FormatPDF

Pages11

Reading Time28 min

AccessFree to download

Introduction

Methods

Results

Discussion

Keywords

TYPE Original Research PUBLISHED 17 June 2024 DOI 10.3389/fpubh.2024.1354663 OPEN ACCESS EDITED BY Mona Pathak, University of North Texas Health Science Center, United States REVIEWED BY Gabriel Madeira Werberich da Silva, National Cancer Institute (INCA), Brazil Mohammad-Mahdi Rashidi, Tehran University of Medical Sciences, Iran *CORRESPONDENCE Belal Nedal Sabbah [bsabbah@alfaisal.edu](bsabbah@alfaisal.edu) †These authors have contributed equally to this work and share first authorship RECEIVED 13 December 2023 ACCEPTED 04 June 2024 PUBLISHED 17 June 2024 CITATION Ghazwani Y, Alghafees M, Suheb MK, Shafqat A, Sabbah BN, Arabi TZ, Razak A, Sabbah AN, Alaswad M, AlKattan W, Ouban A, Abdul Rab S, Shawwaf KA, AlKhamees M, Alasker A, Al-Khayal A, Alsaikhan B, Addar A, Aldosari L, Al Qurashi AA and Musalli Z (2024) Trends in genitourinary cancer mortality in the United States: analysis of the CDC-WONDER database 1999–2020. Front. Public Health 12:1354663 . doi: 10.3389/fpubh.2024.1354663 COPYRIGHT © 2024 Ghazwani, Alghafees, Suheb, Shafqat, Sabbah, Arabi, Razak, Sabbah, Alaswad, AlKattan, Ouban, Abdul Rab, Shawwaf, AlKhamees, Alasker, Al-Khayal, Alsaikhan, Addar, Aldosari, Al Qurashi and Musalli. This isan open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Trends in genitourinary cancer mortality in the United States: analysis of the CDC-WONDER database 1999–2020 Yahia Ghazwani 1, 2, 3†, Mohammad Alghafees 1, 2, 3†, Mahammed Khan Suheb4†, Areez Shafqat 5†, Belal Nedal Sabbah 5*†, Tarek Ziad Arabi 5, Adhil Razak 5, Ahmad Nedal Sabbah 5, Marwan Alaswad 5, Wael AlKattan 5, Abderrahman Ouban 5, Saleha Abdul Rab 5, Kenan Abdulhamid Shawwaf 5, 6, Mohammad AlKhamees 1, 2, 3, Ahmed Alasker 1, 2, 3, Abdullah Al-Khayal 1, 2, 3, Bader Alsaikhan 1, 2, 3, Abdulmalik Addar7, Lama Aldosari 8, Abdullah A. Al Qurashi3, 9 and Ziyad Musalli 1, 2, 3 1College of Medicine at King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Ministry of the National Guard Health Affairs, Riyadh, Saudi Arabia, 2 Division of Urology, King Abdulaziz Medical City, Ministry of the National Guard Health Affairs, Riyadh, Saudi Arabia, 3 King Abdullah International Medical Research Centre, Ministry of the National Guard Health Affairs, Riyadh, Saudi Arabia, 4St. Luke’s Aurora Hospital, Milwaukee, WI, United States, 5College of Medicine, Alfaisal University, Riyadh, Saudi Arabia, 6 Department of Cardiothoracic Surgery, Mayo Clinic, Phoenix, AZ, United States, 7 Department of Urology, McGill University, Montreal, QC, Canada, 8 Department of Urology, King Fahad University Hospital, Khobar, Saudi Arabia, 9College of Medicine, King Saud bin Abdulaziz University for Health Sciences at the National Guards, Jeddah, Saudi Arabia Introduction: Sociodemographic disparities in genitourinary cancer-related mortality have been insufficiently studied, particularly across multiple cancer types. This study aimed to investigate gender, racial, and geographic disparities in mortality rates for the most common genitourinary cancers in the United States. Methods: Mortality data for prostate, bladder, kidney, and testicular cancers were obtained from the Centers for Disease Control and Prevention (CDC) WONDER database between 1999 and 2020. Age-adjusted mortality rates (AAMRs) were analyzed by year, gender, race, urban–rural status, and geographic region using a significance level of p < 0.05. Results: Overall, AAMRs for prostate, bladder, and kidney cancer declined significantly, while testicular cancer-related mortality remained stable. Bla

FAQs

Which cancers and years are analyzed in the study?

The study examines prostate, bladder, kidney, and testicular cancers using mortality data from the CDC WONDER database covering 1999–2020.

What statistical approach is used for mortality trends?

Age-adjusted mortality rates are analyzed by year, gender, race, urban–rural status, and geographic region with a significance threshold of p < 0.05.

What overall pattern is observed in mortality trends?

Age-adjusted mortality rates decline significantly for prostate, bladder, and kidney cancers, while testicular cancer-related mortality remains stable.

Sep 21, 2026

Uploaded by Maeve