TRAJECTORY OF CARDIOMETABOLIC DISEASE-RELATED HOSPITALIZATIONS BEFORE AND AFTER DEMENTIA DIAGNOSIS

Sep 28, 2026

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Cardiometabolic diseases (CMDs) frequently co-occur with dementia, yet how dementia alters CMD-related hospitalizations remains unclear. This study mapped CMD-hospitalization trajectories before and after dementia diagnosis and identified contributing factors. Using the Swedish Twin Registry, 1657 incident dementia participants were propensity-score matched to 1657 dementia-free controls and followed for up to 20 years via medical-record identification of planned and unplanned hospitalizations. CMD incidence rose from four years before diagnosis and declined three years after; greater hospitalization counts and longer stays were observed pre-diagnosis, with male sex, smoking, obesity, and hypertension linked to further increases.

LanguageEnglish

CategoryResearch & Report

FormatPDF

Pages1

Reading Time3 min

AccessFree to download

Methods

Study population

Outcome identification

Covariates and statistical analysis

Results

Pre- and post-diagnosis trajectories

Associated factors

568 Innovation in Aging, 2025, Vol. 9, No. S2 Abstract citation ID: igaf122.1949 TRAJECTORY OF CARDIOMETABOLIC DISEASE-RELATED HOSPITALIZATIONS BEFORE AND AFTER DEMENTIA DIAGNOSIS Sakura Sakakibara, Abigail Dove, Michelle Dunk, Johan Fastbom, Giulia Grande, Ulrika Akenine, and Weili Xu, Karolinska Institutet, Solna, Stockholms Lan, Sweden Cardiometabolic diseases (CMDs) including type 2 diabetes, heart disease, and stroke often co-occur with dementia, but the impact of dementia on hospitalizations related to CMDs remains unknown. We aimed to map the trajectory of CMD-related hospitalization before and after dementia diagnosis and to further identify factors of CMD-related hospitalization. Within the Swedish Twin Registry, 1657 participants aged ≥65 with incident dementia were matched with 1657 dementia-free participants using propensity scores. Participants were followed for up to 20 years to detect CMD-related hospitalizations. Dementia and CMD-related hospitalizations (planned and unplanned) were identified from medical records. Potential related factors included age, sex, education, marital status, smoking, drinking, physical activity, body mass index, and hypertension. Data were analyzed using Poisson regression and generalized estimating equation models. Compared to the controls, the incidence of CMD-related hospitalization among people with dementia started to increase from 4 years before (incidence rate ratio [IRR] 1.25, 95% confidence interval [CI] 1.00-1.57) and started to decrease 3 years after, the diagnosis (IRR 0.74, CI 0.58-0.94). People with dementia had a greater number of CMD-related hospitalizations (IRR 1.19, CI 1.04-1.36) and longer cumulative length of stay (IRR 1.27, CI 1.04-1.56) in the five years before dementia diagnosis, but these rates decreased after the diagnosis. Male sex, smoking, obesity, and hypertension were associated with further increases in CMD-related hospitalization among people with dementia. Our findings suggest that the healthcare burden increases even before the diagnosis of dementia, and CMD-related hospitalization may be an early sign of the future onset of dementia.

FAQs

What question does the study address about dementia and CMD hospitalizations?

It examines how the trajectory of CMD-related hospitalizations changes before and after a dementia diagnosis and which factors may contribute to that hospitalization pattern.

How were participants selected and followed in this research?

The Swedish Twin Registry provided 1657 participants with incident dementia (aged ≥65) matched to 1657 dementia-free controls using propensity scores, followed for up to 20 years.

When did CMD-related hospitalization incidence change relative to dementia diagnosis?

Incidence began increasing about four years before diagnosis and started to decrease about three years after the diagnosis.

Which factors were associated with further increases in CMD-related hospitalization among people with dementia?

Male sex, smoking, obesity, and hypertension were associated with further increases in CMD-related hospitalization among people with dementia.

Sep 28, 2026

Upload by Stanley