Tooth loss in breast cancer patients - A comparison between tamoxifen-treated and non-treated patients

Q: What was the study objective regarding tooth loss and tamoxifen?

To determine the relationship between tooth loss and tamoxifen consumption in patients with breast cancer.

Q: How was the study conducted and who were the participants?

A cross-sectional observational study was conducted from July to September 2023, evaluating 200 adult breast cancer patients in Trujillo, Peru: 100 consumed tamoxifen and 100 did not.

Q: What key findings were reported about tooth loss?

No overall relationship was found between tooth loss and tamoxifen consumption, but tooth loss was greater in women who used tamoxifen for more than one year and in older women.

Sep 21, 2026

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Tooth loss affects quality of life and general health, and evidence on whether tamoxifen use in breast cancer patients increases tooth loss risk remains limited. This cross-sectional observational study evaluated 200 adult breast cancer patients in Trujillo, Peru (100 tamoxifen users, 100 non-users) and assessed inter- and intrarater reliability for tooth loss measurements. Poisson regression tested associations, showing no overall link, but greater tooth loss after more than one year of tamoxifen use and in older women.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages7

Reading Time18 min

AccessFree to download

Abstract

Background

Material and Methods

Results

Conclusions

Introduction

Med Oral Patol Oral Cir Bucal. 2024 Jul 1;29 (4):e552-8 . Tamoxifen and tooth loss in breast cancer patients Journal section: Medically compromised patients in Dentistry doi:10.4317/medoral.26528 Publication Types: Research Tooth loss in breast cancer patients: A comparison between tamoxifen-treated and non-treated patients Jane Janet Julca-Baltazar 1, Angel Seven Asmat-Abanto 2, Andy Ray Pantoja Lázaro 3, Ana Paula GorrittiRubio 4, Carlos Alberto Minchón-Medina 5 1 Orcid: 0009-0007-3953-8296. Student of Stomatology Study Program. Antenor Orrego Private University, Trujillo, Peru 2 Orcid: 0000-0001-5726-6692 . Doctor in Stomatology. Specialist in Periodontics. Professor of Human Medicine Study Program. Antenor Orrego Private University, Trujillo, Peru; Professor of Stomatology Study Program. Antenor Orrego Private University, Trujillo, Peru 3 Orcid: 0009-0008-4119-5832. Specialist in Oncological Surgery. Sub-specialist in Oncological Surgery of Breasts, Skin and Soft Tissues. Chief of the Department of Oncological Surgery of Breasts and Soft Tissue Tumors of the Regional Institute of Neoplastic Diseases IREN Norte “Dr. Luis Pinillos Ganoza”, Trujillo, Peru 4 Orcid: 0009-0002-1486-9068 . Specialist in Medical Oncology. Assistant physician of the Medical Oncology Service of the High Complexity Hospital "Virgen de la Puerta"; Professor of Human Medicine Study Program. Antenor Orrego Private University, Trujillo, Peru 5 Orcid: 0000-0002-2441-5302. Doctor in Public Health, Postgraduate Professor. Department of Statistics, Trujillo National University, Trujillo, Peru Correspondence: America Sur Avenue N° 3145 Monserrate Neighborhood Trujillo, 13008, Peru [aasmat.abanto@gmail.com](aasmat.abanto@gmail.com) [Received: 09/01/2024](Received: 09/01/2024) [Accepted: 29/04/2024](Accepted: 29/04/2024) Julca-Baltazar JJ, Asmat-Abanto AS, Pantoja-Lázaro AR, Gorritti-Rubio AP, Minchón-Medina CA. Tooth loss in breast cancer patients: A comparison between tamoxifen-treated and non-treated patients. Med Oral Patol Oral Cir Bucal. 2024 Jul 1;29 (4):e552-8 . Article Number:26528 [http://www.medicinaoral.com/](http://www.medicinaoral.com/) © Medicina Oral S. L. C.I.F. B 96689336-pISSN 1698-4447-eISSN: 1698-6946 eMail: [medicina@medicinaoral.com](medicina@medicinaoral.com) Indexed in: Science Citation Index Expanded Journal Citation Reports Index Medicus, MEDLINE, PubMed Scopus, Embase and Emcare Indice Médico Español Abstract Background: Tooth loss (TL) affects quality of life and general health. The literature suggesting that tamoxifen treatment in patients with breast cancer (BC) could be associated with alterations in oral health, increasing the risk of TL, is still scarce. This work aimed to determine the relationship between TL and tamoxifen consumption in patients with BC. Material and Methods: This cross-sectional observational study was carried out from July to September 2023 in the medical oncology services of the “Virgen de la Puerta” -ESSALUD High Complexity Hospital and “Dr. Luis Pinillos Ganoza” -IREN Norte-Regional Institute of Neoplastic Diseases, in Trujillo-Peru. Overall, 200 adult patients diagnosed with BC were evaluated, of which 100 consumed tamoxifen and 100 did not. Inter-and intrarater reliability was determined with respect to TL, resulting in intra-class correlation values RHO = 0.971 and interclass RHO = 0.938. The oncologist of the corresponding service performed BC diagnosis and stage. Poisson regression was used to analyze results with a significance level ofp<0.05. Results: No relationship was found between TL and tamoxifen consumption in patients with breast cancer (p= 0.221); however, greater TL was observed in women who consumed tamoxifen for more than one year compared to those who did not use it (p=0.025) and in older adult women compared to young women (p=0.030). Conclusions: There is a relationship between TL and time of use of tamoxifen in patients with BC, c

FAQs

What was the study objective regarding tooth loss and tamoxifen?

To determine the relationship between tooth loss and tamoxifen consumption in patients with breast cancer.

How was the study conducted and who were the participants?

A cross-sectional observational study was conducted from July to September 2023, evaluating 200 adult breast cancer patients in Trujillo, Peru: 100 consumed tamoxifen and 100 did not.

What key findings were reported about tooth loss?

No overall relationship was found between tooth loss and tamoxifen consumption, but tooth loss was greater in women who used tamoxifen for more than one year and in older women.

Sep 21, 2026

Upload by Noah