TIME TO LOOK BEYOND AGE? - FRAILTY AS THE KEY DETERMINANT OF EVT PROGNOSIS IN ACUTE ISCHEMIC STROKE PATIENTS - ≥75 YEARS

Sep 29, 2026

Stroke is a major public health concern, and endovascular treatment (EVT) is increasingly used in older acute ischemic stroke (AIS) patients, yet evidence on the role of frailty in prognosis after EVT remains limited for those aged 75 years and older. This study evaluated frailty as a prognostic indicator after EVT using the Clinical Frailty Scale, with 193 patients and multivariable logistic regression. Frailty and stroke history predicted poor 3-month outcomes, supporting frailty assessment for clinical decision-making.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages1

Reading Time3 min

AccessFree to download

Background

Objective

Methods

Results

Conclusions

Innovation in Aging, 2025, Vol. 9, No. S2 1301 Abstract citation ID: igaf122.4336 TIME TO LOOK BEYOND AGE? FRAILTY AS THE KEY DETERMINANT OF EVT PROGNOSIS IN ACUTE ISCHEMIC STROKE PATIENTS ≥75 YEARS Wenhua Yu, and Lina Ma, Xuanwu Hospital, Capital Medical University, Beijing, Beijing, China (People’s Republic) Background: Stroke is a major public health concern worldwide and the primary cause of adult mortality in China. Endovascular treatment (EVT) has been increasingly utilized in older acute ischemic stroke (AIS) patients; however, there is limited data regarding the association between frailty and prognosis after EVT in individuals aged ≥75 years. Objective: To evaluate frailty assessment as a prognostic indicator following EVT inpatients with AIS aged ≥75 years. Methods: We included 193 patients with AIS aged ≥75 years who underwent EVT at Xuanwu Hospital of Capital Medical University from May 2013 to July 2023. Frailty was assessed using the Clinical Frailty Scale. The primary outcome was defined as a favorable modified Rankin Scale score of 0–1 at 3 months after EVT. We used multivariable logistic regression to evaluate the impact of frailty on clinical outcomes. Results: The mean age of participants was 80.34±4.39 years. Frailty, older age, female sex, consumed less alcohol, stroke history, coronary heart disease, more chronic diseases, lower Barthel Index, higher admitted National Institutes of Health Stroke Scale scores, higher fasting blood glucose levels, higher neutrophil percentage, higher D-Dimer levels and lower hemoglobin levels were associated with unfavorable outcomes. Logistic regression analysis revealed that frailty and stroke history were associated with poor prognosis after EVT in older adults with AIS. Conclusions: Frailty is an indicator of poor prognosis following EVT in patients with AIS aged ≥75 years. Frailty assessment provides valuable insights for clinical decision-making, helping guide more informed EVT decisions in this age group.

FAQs

What was the study objective regarding frailty and EVT outcomes?

To evaluate whether frailty assessment predicts prognosis after EVT in AIS patients aged 75 years and older.

How were frailty and the main clinical outcome measured?

Frailty was assessed using the Clinical Frailty Scale. The primary outcome was a favorable modified Rankin Scale score of 0–1 at 3 months after EVT.

Which factors were associated with unfavorable outcomes after EVT?

Unfavorable outcomes were associated with frailty, older age, female sex, less alcohol consumption, stroke history, coronary heart disease, more chronic diseases, lower Barthel Index, higher NIH Stroke Scale scores, higher fasting blood glucose, higher neutrophil percentage, higher D-Dimer levels, and lower hemoglobin levels.

Sep 29, 2026

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