There is an urgent need for safer anti-SARS-CoV-2 vaccines - Letter to the editor

Sep 29, 2026

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Letter to the editor addressing concerns about the safety of mRNA-based anti-SARS-CoV-2 vaccines. The author responds to a prior article claiming broad safety and effectiveness across age groups, arguing that pediatric and adult side effects are often transient but can include serious adverse reactions such as thrombosis, myocarditis, neurologic disorders, and reproductive complications. The letter further highlights potential persistent mild symptoms and calls for development of new vaccines with higher safety profiles to improve public trust.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages1

Reading Time3 min

AccessFree to download

Letter to the editor

Response to prior article

Disagreement on general safety

Severe and persistent adverse effects

Need for safer vaccine development

J Chin MedAssoc Letter to the editor There is an urgent need for safer anti-SARS-CoV-2 vaccines Josef Finsterera,* aNeurology & Neurophysiology Center, Vienna, Austria DEAR EDITOR, We eagerly read the article by Liang et al1 about the efficacy of anti-severe acquired respiratory distress syndrome-coronavirus-2 (SARS-CoV-2) vaccinations in the pediatric population, its side effects, the balance between benefit and risk, and future perspectives. It was concluded that all age groups, including infants, children, adolescents, adults, and elders, are susceptible to SARSCoV-2 and its variants of concern, including the most recent Omicron strain, that the currently available data from clinical trials and the real world indicate that the mRNA vaccines are generally safe and effective against SARS-CoV-2, and that the benefits of vaccination outweigh its risks. The considerations are appealing but raise concerns which require discussion. We disagree with the statement that mRNA-based anti-SARSCoV-2 vaccines are generally safe as mentioned in the abstract.1 mRNA-based anti-SARS-CoV-2 vaccines frequently cause side effects in pediatric patients and adults but they are in the majority of cases transient and do not require hospitalization. However, there are a number of adverse reactions, which require attention, because they may require hospitalization, may have an incomplete outcome, or may be even lethal.2 Therefore, anti-SARS-CoV-2 vaccinations may prevent death, but they may also cause harm or fatalities. Severe side effects reported in the pediatric or adult population include thrombocytopenia, multisystem inflammatory syndrome-children, thrombosis, myocarditis, bronchiolitis,3 pancreatitis, Guillain Barre syndrome, meningitis, stroke, encephalitis, hypophysitis, acute, hemorrhagic encephalopathy, acute disseminated encephalomyelitis, epilepsy, multiple sclerosis, and myasthenia.4 Vaccinations may also cause placentitis and may secondarily cause stillbirth.5 Furthermore, not all side effects that occur are also reported to the health authorities or published. There are also patients who develop only mild symptoms after an mRNA-based vaccine but these side effects may persist over months, therefore severely interfering with mood, the daily activities, and the social status (long post-SARS-CoV-2 vaccination syndrome).6 Therefore, there is a need to prevent even mild side effects if they persist. Those who experience severe side effects or even death following an anti-SARS-CoV-2 vaccination, often wish not having ever received the vaccine, whereas those who have lost unvaccinated relatives due to COVID-19 may wish that their lost relatives would have been vaccinated. These divergent needs need tobe accomplished, and this may be achieved only through developing completely new vaccines with higher safety profile than those currently on the market. There is an urgent need to invent anti-SARS-CoV-2 vaccines without major side effects, to win the trust of vaccine sceptics. REFERENCES 1. Liang KH, Hung KF, Wang ML, Chang TJ, Cheng YF, Chiang SH, et al. SARS-CoV-2 vaccines in children and adolescents: can immunization prevent hospitalization? J Chin Med Assoc 2022;85:891–5 . 2. Finsterer J. Neurological side effects of SARS-CoV-2 vaccinations. Acta Neurol Scand 2022;145:5–9 . 3. Lee M, Hwang JY, Park SE, Jung S, Jo KJ. A case report of postinfectious bronchiolitis obliterans after coronavirus disease 2019 in a 10-year-old child. J Korean Med Sci 2022;37:e246 . 4. Consolini R, Costagliola G, Spada E, Colombatto P, Orsini A, Bonuccelli A, et al. Case report: MIS-C with prominent hepatic and pancreatic involvement in a vaccinated adolescent - a critical reasoning. Front Pediatr 2022;10:896903 . 5. Konstantinidou AE, Angelidou S, Havaki S, Paparizou K, Spanakis N, Chatzakis C, et al. Stillbirth due to SARS-CoV-2 placentitis without evidence of intrauterine transmission to fetus: association with maternal risk facto

FAQs

Why does the author call for developing new vaccines?

The author states that severe outcomes and persistent mild effects create divergent patient needs and undermines trust, so vaccines with a higher safety profile than current options are urgently needed.

Sep 29, 2026

Uploaded by moss~