The use of non-steroid anti-inflammatory drugs during radical resection correlated with the outcome in non-small cell lung cancer - Research Open Access

Q: What clinical factors differed between low and high UI groups?

Clinical features including type of resection, N stage, and TNM stage differed significantly between UI-low and UI-high subgroups.

Sep 24, 2026

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The study evaluates whether non-steroid anti-inflammatory drugs (NSAIDs) used during radical surgery carry prognostic value in non-small cell lung cancer (NSCLC). Retrospective patients staged I–III are stratified by NSAID use intensity derived from accumulated dosage relative to hospitalization length, then clinical features and survival are compared. Disease-free survival and overall survival are analyzed using Kaplan–Meier methods, with Cox proportional hazards testing for risk factors. Higher use intensity shows better DFS and OS, and NSAID use intensity emerges as an independent DFS risk factor.

LanguageEnglish

CategoryHealthcare

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Pages10

Reading Time25 min

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Cai etal. World Journal of Surgical Oncology (2023) 21:358 [https://doi.org/10.1186/s12957-023-03247-8](https://doi.org/10.1186/s12957-023-03247-8) World Journal of Surgical Oncology RESEARCH Open Access The use of non-steroid anti-inflammatory drugs during radical resection correlated with the outcome in non-small cell lung cancer Renzhong Cai1†, Xuqiang Liao1†, Gao Li1†, Jia Xiang2, Qianwen Ye2, Minbiao Chen1*† and Shouhan Feng3*† Abstract Aims The use of non-steroid anti-inflammatory drugs (NSAIDs) is conventional in management of postoperative pain in cancer patients, and further investigations have reported that some of these drugs correlated with the outcome in cancers. However, the prognostic value of the use of NSAIDs during surgery in non-small cell lung cancer (NSCLC) patients has been less addressed. Methods NSCLC patients staged I–III are retrospectively enrolled, and the data of the use of NSAIDs during surgery are collected. Patients are divided into two subgroups according to the use intensity (UI) (low or high) of the NSAIDs, which was calculated by the accumulate dosage of all the NSAIDs divided by the length of hospitalization. The differences ofthe clinical features among these groups were checked. And the disease-free survival (DFS) and overall survival (OS) differences in these groups were compared by Kaplan–Meier analysis; risk factors for survival were validated by using a Cox proportional hazards model. Results The UI was significant in predicting the DFS (AUC = 0 . 65, 95% CI: 0 .57–0. 73, P = 0 . 001) and OS (AUC = 0 . 70, 95% CI: 0 .59–0. 81, P = 0 . 001) . Clinical features including type of resection (P = 0 . 001), N stages (P < 0. 001), and TNM stages (P = 0 . 004) were significantly different in UI low (< 74.55 mg/day) or high (≥ 74.55 mg/day) subgroups. Patients in UI-high subgroups displayed significant superior DFS (log rank = 11 .46, P = 0 . 001) and OS (log rank = 7 . 63, P = 0 . 006) than the UI-low ones. At last, the UI was found to be an independent risk factor for DFS (HR: 0 . 52, 95% CI: 0 .28–0. 95, P = 0 . 034) . Conclusions The use of NSAIDs during radical resection in NSCLC patients correlated with the outcome and patients with a relative high UI has better outcome. Keywords Lung cancer, Non-steroid anti-inflammatory drugs, Surgery, Disease-free survival, Overall survival †Renzhong Cai, Xuqiang Liao, Gao Li, Minbiao Chen, and Shouhan Feng contributed equally. *Correspondence: Minbiao Chen [Chenminbiaokeyan@163.com](Chenminbiaokeyan@163.com)[ ](Chenminbiaokeyan@163.com)Shouhan Feng [fengshouhan@sina.com](fengshouhan@sina.com) 1 Department of Thoracic Surgery, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou City, Hainan Province 570311, People’s Republic of China 2 Department of Oncology, Hainan Hospital of PLA General Hospital, Sanya City, Hainan Province 572000, People’s Republic of China 3 Department of Oncology, Huzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University, Huzhou City, Zhejiang Province 313000, People’s Republic of China © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creativec

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What clinical factors differed between low and high UI groups?

Clinical features including type of resection, N stage, and TNM stage differed significantly between UI-low and UI-high subgroups.

Sep 24, 2026

Uploaded by Blitz