The relationship between cognitive screeners and everyday functioning in amyloid-positive participants from the Amsterdam Dementia Cohort - Research article

Sep 29, 2026

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Explores how cognitive screening outcomes relate to real-world everyday functioning in Alzheimer’s disease among amyloid-positive individuals. Using data from 1228 participants in the Amsterdam Dementia Cohort, multiple linear regression links MMSE and MoCA to everyday functioning assessed with the A-IADL-Q-30. Results show both MMSE and MoCA are associated with IADL difficulties, with distinct impairment patterns across lower versus higher quartiles. Findings indicate moderate cognition–function associations and support joint assessment for disease monitoring.

LanguageEnglish

CategoryResearch & Report

FormatPDF

Pages11

Reading Time28 min

AccessFree to download

Abstract

Introduction

Methods

Results

Discussion

Background

Alzheimer’s disease and cognitive staging

Cognitive screening tools and clinical meaningfulness

IADLs as interpretable everyday functioning

DOI: 10.1002/dad2.70233 RESEARCH ARTICLE The relationship between cognitive screeners and everyday functioning in amyloid-positive participants from the Amsterdam Dementia Cohort Angela van der Putten-Toorenburg1, 2 Elke Butterbrod1, 2 Benjamin D. Schalet3 Pieter J. van der Veere2,4 Mukrabe E. Tewolde2,4 Merel C. Postema2,4 Elsmarieke van de Giessen4, 5 Charlotte E. Teunissen4, 6 Argonde C. van Harten2,4 Wiesje M. van der Flier2, 3,4 Sietske A. M. Sikkes1, 2,4 1 Faculty of Behavioural and Movement Sciences, Department of Clinical, Neuro-and Developmental Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands 2Alzheimer Center Amsterdam, Department of Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands 3 Department of Epidemiology and Data Science, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands 4Amsterdam Neuroscience-Neurodegeneration, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands 5 Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands 6 Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam Neuroscience, Amsterdam UMC Vrije Universiteit Amsterdam, Amsterdam, The Netherlands Correspondence Angela van der Putten-Toorenburg, Faculty of Behavioural and Movement Sciences, Department of Clinical, Neuro-and Developmental Psychology, Vrije Universiteit, De Boelelaan 1105, 1081 HV Amsterdam, The Netherlands. Email: [a.vander.putten-toorenburg@vu.nl](a.vander.putten-toorenburg@vu.nl) Funding information TAP-dementia; ZonMw, Grant/Award Number: \#10510032120003; Dutch National Dementia Strategy Abstract INTRODUCTION: We explored the relationship between cognitive screening outcomes and everyday functioning in Alzheimer’s disease (AD). METHODS: A total of 1228 amyloid-positive participants were included from the Amsterdam Dementia Cohort. Multiple linear regression analyses assessed the relationship between Mini-Mental State Examination(MMSE), Montreal Cognitive Assessment (MoCA), and everyday functioning (Amsterdam Instrumental Activities of Daily Living Questionnaire [A-IADL-Q-30]). To link cognitive screeners to functional impairment, we described difficulties across A-IADL-Q-30 items by MMSE and MoCA quartiles. RESULTS: Both MMSE (B = 0. 96, 95% confidence interval [CI]0.87–1.04) and MoCA (B = 0. 79, 95% CI 0.68–0.89) were associated with A-IADL-Q-30. In the lowest MMSE (0–20) and MoCA (0–16) quartiles, filling in forms (both 96%) and managing the household budget (95%–93%) were mostly affected, whereas working (74%) and using a computer (52%–50%) were primarily affected in the highest quartiles (MMSE 28–30/MoCA 25–30). This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2026 The Author(s). Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer’s Association. Alzheimer’s Dement. 2026;18:e70233. [https://doi.org/10.1002/dad2.70233](https://doi.org/10.1002/dad2.70233) wi[leyonlinelibrary.com/journal/dad2](leyonlinelibrary.com/journal/dad2) 1of11 DISCUSSION: In amyloid-positive participants, the association between cognition and daily functioning was moderate, reinforcing the importance of assessing both constructs in disease monitoring. KEYWORDS Alzheimer’s disease, clinical meaningfulness, everyday functioning, global cognition, instrumental activities of daily living, preclinical AD Highlights ∙ Cognitive screening tools were moderately associated with daily functioning. ∙ Difficulties in complex daily tasks were present in the higher cognitive performance quartiles. ∙ Findings suggest that combining cognition and function is required for disea

FAQs

What is the document studying about cognitive screeners and everyday functioning?

It examines the relationship between cognitive screening outcomes (MMSE and MoCA) and everyday functioning measured by A-IADL-Q-30 in amyloid-positive participants with Alzheimer’s disease.

How many amyloid-positive participants were included, and what methods were used?

A total of 1228 amyloid-positive participants were included. Multiple linear regression analyses tested associations between MMSE, MoCA, and everyday functioning, and item-level difficulties were described across score quartiles.

What daily activities showed the most impairment in the lowest cognitive quartiles?

In the lowest MMSE (0–20) and MoCA (0–16) quartiles, filling in forms and managing the household budget were mostly affected.

What is concluded about the cognition–function relationship for disease monitoring?

In amyloid-positive participants, the association between cognition and daily functioning was moderate, supporting the importance of assessing both constructs together in disease monitoring.

Sep 29, 2026

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