The prognostic value of calcium channel blockers usage for overall survival and recurrence-free survival in patients with endometrial cancer

Q: What is the study objective regarding calcium channel blockers in endometrial cancer?

To evaluate how calcium channel blocker use affects prognosis in endometrial cancer patients with hypertension and to assess its predictive function for outcomes.

Q: How were patients selected and how were the data split for analysis?

Patients diagnosed with endometrial cancer who underwent surgery between January 2014 and December 2023 were enrolled and divided into a training set and a validation set in a 2:1 ratio.

Q: What were the main findings about CCB use and patient survival outcomes?

After adjusting for confounders, CCB use remained independently predictive of improved overall survival and recurrence-free survival, and adding CCB use improved predictive accuracy in both cohorts.

Sep 30, 2026

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Objective evaluates the prognostic impact of calcium channel blocker (CCB) use in endometrial cancer patients with hypertension and examines its predictive performance. Methods enroll surgical EC patients from January 2014 to December 2023, split into training and validation cohorts (2:1). Univariate and multivariate analyses identify predictive factors, while ROC and DCA test CCB value for overall survival and recurrence-free survival; survival and calcium-related analyses further support associations. Results show CCB use remains independently associated with improved OS and RFS after confounder adjustment, with enhanced predictive accuracy when CCB is incorporated. Conclusion indicates hypertensive EC patients using CCB have significantly improved OS and RFS prediction consistency across cohorts.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages11

Reading Time28 min

AccessFree to download

Abstract

Introduction

Cheng et al. European Journal European Journal of Medical Research (2026) 31:24 [https://doi.org/10.1186/s40001-025-03621-0](https://doi.org/10.1186/s40001-025-03621-0 of Medical Research)[ of Medical Research](https://doi.org/10.1186/s40001-025-03621-0 of Medical Research) RESEARCH Open Access The prognostic value of calcium channel blockers usage for overall survival and recurrence-free survival in patients with endometrial cancer Yun Cheng1,2†, Chen Yan1†, Yongmin Lv2†, Jie Chen1, Qianqian Lu1, Jingyan Xie2* and Xin Zeng1* Abstract Objective To evaluate the prognosis for endometrial cancer (EC) patients who used calcium channel blockers (CCB) with hypertension and its predictive function. Methods Patients diagnosed with EC who underwent surgery at our hospital between January 2014 and December 2023 were enrolled and divided into a training set and a validation set at a 2:1 ratio. Clinical characteristics and medical information were extracted from patient records. Predictive factors were assessed using univariate and multivariate analyses in the training set. ROC and DCA were employed to evaluate the predictive value of CCB in both the training and validation sets. Survival analysis was conducted to investigate function of antihypertensive drugs and calcium level. Results In the training set, univariate analysis showed that age, CA125, CCB use, tumor grade, FIGO stage, histological type, peritoneal cytology, lymph node metastasis, and lymph-vascular space invasion (LVSI) were significantly associated with overall survival (OS) and recurrence-free survival (RFS; all P < 0. 05) . After adjusting for confounders, CCB use remained independently predictive of improved OS (Model I: HR = 0 . 1, 95% CI: 0 .0–0.4, P < 0. 001; Model II: HR = 0 . 2, 95% CI: 0 .1–0. 5, P = 0 . 006) and RFS (Model I: HR = 0 . 2, 95% CI: 0 .1–0. 5, P < 0. 001; Model II: HR = 0 . 2, 95% CI: 0 .1–0. 7, P = 0 . 009) . Both CCB and calcium ion levels have significant impacts on the long-term survival of patients with hypertension. ROC and DCA demonstrated that incorporating CCB use significantly enhanced diagnostic accuracy for OSand RFS in both the training and validation sets. Survival analyses further supported these findings. Conclusion This study suggests that hypertensive EC patients using CCB exhibit significantly improved OS and RFS prediction accuracy, with consistent results across training and validation cohorts. Keywords Endometrial cancer, Serum calcium, Calcium channel blockers, Prognosis, Recurrence free survival †Yun Cheng, Chen Yan, and Yongmin Lv contributed equally to this article. *Correspondence: Jingyan Xie [czfengjing2020@163.com](czfengjing2020@163.com)[ ](czfengjing2020@163.com)Xin Zeng [cyliuyi2002@163.com](cyliuyi2002@163.com) © The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creativecommons.org/licenses/by-nc-nd/4.0/](http://creativecommons.org/licenses/by-nc-nd/4.0/.)[.](http://creativecommons.org/licenses/by-nc-nd/4.0/.) Cheng et al. European Journal of Medical R

FAQs

What is the study objective regarding calcium channel blockers in endometrial cancer?

To evaluate how calcium channel blocker use affects prognosis in endometrial cancer patients with hypertension and to assess its predictive function for outcomes.

How were patients selected and how were the data split for analysis?

Patients diagnosed with endometrial cancer who underwent surgery between January 2014 and December 2023 were enrolled and divided into a training set and a validation set in a 2:1 ratio.

What were the main findings about CCB use and patient survival outcomes?

After adjusting for confounders, CCB use remained independently predictive of improved overall survival and recurrence-free survival, and adding CCB use improved predictive accuracy in both cohorts.

Sep 30, 2026

Uploaded by kopisore