The impact of hypophosphatemia on biochemical profile and renal outcomes in primary hyperparathyroidism: a nationwide retrospective study

Q: How were PHPT patients selected for the retrospective analysis?

PHPT cases were identified from Turkey’s National Electronic Database using ICD-10 diagnostic codes and laboratory data for the years 2017 to 2022.

Q: What proportion of patients had hypophosphatemia, and what were its associations?

Hypophosphatemia (P < 2.5 mg/dL) was present in 14.3% of patients and was associated with higher PTH, calcium, and alkaline phosphatase levels, and lower vitamin D levels.

Q: Does hypophosphatemia independently affect kidney stone risk in PHPT?

Yes. HypoP independently increased the risk of kidney stone formation (OR = 1.53; 95% CI 1.46–1.61).

Sep 30, 2026

Uploaded by WPS_1790064749

Association between serum phosphorus levels and clinical outcomes in primary hyperparathyroidism (PHPT) is assessed using Turkey’s National Electronic Database to identify PHPT cases from 2017–2022. Records from 113,330 patients were analyzed, describing baseline serum phosphorus and defining hypophosphatemia as P <2.5 mg/dL. HypoP occurred in 14.3% and correlated with higher PTH, calcium, alkaline phosphatase, and lower vitamin D. HypoP independently increased kidney-stone risk, supporting routine phosphorus monitoring in PHPT management.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages11

Reading Time28 min

AccessFree to download

Background/aim

Materials and methods

Results

Conclusion

Key words

Introduction

Turkish Journal of Medical Sciences | Volume 55 Number 6 | Article 4 | | --- | --- | | 12-12-2025
The impact of hypophosphatemia on biochemical profile and renal outcomes in primary hyperparathyroidism: a nationwide retrospective study
NAİM ATA BEKİR UÇAN HALİL DURANTAŞ OĞULCAN BOZ MUSTAFA ŞAHİN
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Follow this and additional works at: [https://journals.tubitak.gov.tr/medical](https://journals.tubitak.gov.tr/medical)
Part of the Medical Sciences Commons | | Recommended Citation ATA, N, UÇAN, B, DURANTAŞ, H, BOZ, O, ŞAHİN, M, ÜLGÜ, M, BİRİNCİ, Ş, & KIZILGÜL, M (2025) . The impact of hypophosphatemia on biochemical profile and renal outcomes in primary hyperparathyroidism: a nationwide retrospective study. Turkish Journal of Medical Sciences 55 (6): 1372-1380 . [https://doi.org/](https://doi.org/)[ ](https://doi.org/)10.55730/1300-0144.6095 This work is licensed under a Creative Commons Attribution 4.0 International License. This Research Article is brought to you for free and open access by TÜBİTAK Academic Journals. It has been accepted for inclusion in Turkish Journal of Medical Sciences by an authorized editor of TÜBİTAK Academic Journals. For more information, please contact [academic.publications@tubitak.gov.tr](academic.publications@tubitak.gov.tr) The impact of hypophosphatemia on biochemical profile and renal outcomes in primary hyperparathyroidism: a nationwide retrospective study Authors NAİM ATA, BEKİR UÇAN, HALİL DURANTAŞ, OĞULCAN BOZ, MUSTAFA ŞAHİN, MUSTAFA MAHİR ÜLGÜ,ŞUAYİP BİRİNCİ, and MUHAMMED KIZILGÜL This research article is available in Turkish Journal of Medical Sciences: [https://journals.tubitak.gov.tr/medical/](https://journals.tubitak.gov.tr/medical/)[ ](https://journals.tubitak.gov.tr/medical/)vol55/iss6/4 |
| Turkish Journal of Medical Sciences [http://journals.tubitak.gov.tr/medical/](http://journals.tubitak.gov.tr/medical/)

Research Article | Turk J Med Sci
(2025) 55: 1372-1380 © TÜBİTAK
doi:10.55730/1300-0144.6095 | | --- | --- | --- | The impact of hypophosphatemia on biochemical profile and renal outcomes in primary hyperparathyroidism: a nationwide retrospective study Naim ATA1,*􀁋, Bekir UÇAN2􀁋, Halil DURANTAŞ2􀁋, Oğulcan BOZ2􀁋, Mustafa ŞAHİN3􀁋, M. Mahir ÜLGÜ1􀁋, Şuayip BİRİNCİ4􀁋, Muhammed KIZILGÜL2,5􀁋 1 General Directorate of Health Information System, Turkish Ministry of Health, Ankara, Turkiye 2 Department of Endocrinology and Metabolism, Etlik City Hospital, Ankara, Turkiye 3 Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Ankara University, Ankara, Turkiye 4 Deputy Minister, Turkish Ministry of Health, Ankara, Turkiye 5 Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, University of Minnesota, Minneapolis, USA Received: 11.10.2025 Accepted/Published Online: 04.11.2025 Final Version: 12.12.2025 Background/aim: Although low phosphorus (P) concentrations are a recognized feature of primary hyperparathyroidism (PHPT), they are not among the diagnostic or surgical criteria. The present study evaluates the association between serum phosphorus levels and clinical outcomes in PHPT patients. Materials and methods: A search of the Turkish Ministry of Health’s National Electronic Database was conducted using ICD-10 diagnostic codes and laboratory data to identify PHPT cases within the Turkish population from 2017 to 2022. Results: The records of a total of 113,330 PHPT patients (77.5% female; mean age 58.9 ± 15.6 years) were analyzed, revealing a mean serum phosphorus level of 3.24 ± 0.79 mg/dL. Patients with nephrolithiasis, vitamin D <20 µg/L, and calcium ≥11.4 mg/dL had significantly lower phosphorus levels (p<0.0001) . Hypophosphatemia (HypoP) (P < 2.5 mg/dL) was present in 14.3% of patients and was associated with higher parathyroid hormone, calcium, and alkaline phosphatase levels, and lower vitamin D lev

FAQs

How were PHPT patients selected for the retrospective analysis?

PHPT cases were identified from Turkey’s National Electronic Database using ICD-10 diagnostic codes and laboratory data for the years 2017 to 2022.

What proportion of patients had hypophosphatemia, and what were its associations?

Hypophosphatemia (P < 2.5 mg/dL) was present in 14.3% of patients and was associated with higher PTH, calcium, and alkaline phosphatase levels, and lower vitamin D levels.

Does hypophosphatemia independently affect kidney stone risk in PHPT?

Yes. HypoP independently increased the risk of kidney stone formation (OR = 1.53; 95% CI 1.46–1.61).

Sep 30, 2026

Uploaded by WPS_1790064749