The high expression of ADRM1 in hepatocellular carcinoma is closely related to tumor immune infiltration and is regulated by miR-891a-5p

Sep 21, 2026

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Hepatocellular carcinoma remains a high-mortality cancer with poor prognosis, prompting investigation into new molecular mechanisms. This study explores the relationship between adhesion-regulating molecule 1 (ADRM1), patient prognosis, and tumor immune infiltration. ADRM1 is highly expressed in tumors and correlates with adverse outcomes in hepatocellular carcinoma. In hepatocellular carcinoma tissues, miR-891a-5p regulates ADRM1, where increased miR-891a-5p raises ADRM1 expression and reduced miR-891a-5p lowers it. The work suggests ADRM1 as a key driver and proposes miR-891a-5p/ADRM1 as an anti-HCC drug research direction.

LanguageEnglish

CategoryResearch & Report

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Pages14

Reading Time35 min

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Results

Pan-cancer displays the manifestation of ADRM1

[www. nature.com/scientificreports](www. nature.com/scientificreports) OPEN The high expression of ADRM1 in hepatocellular carcinoma is closely related to tumor immune infiltration and is regulated by miR‑891a‑5p Ziqi Shao1,2, Yuan Wang1,2, Yuejun He1, Chen Zhang1, Yandong Zhao1, Mimi Zhang1, Qiang Li1* & Jian Wang1* Liver cancer is one of the most common malignant tumors worldwide. Although some progress has been made in the diagnosis and treatment of Hepatocellular carcinoma (HCC), the diagnosis and treatment of HCC is still facing great challenges because of the high mortality rate and poor prognosis of HCC. The purpose of this study was to explore the relationship between adhesion‑ regulating molecule1 (ADRM1), and liver cancer, and the relationship between prognoses. ADRM1 is highly expressed in tumors and is closely associated with the prognosis of patients with liver cancer. In our previous study, we found that ADRM1 was highly expressed in HCC and was closely related to tumor immune and immune checkpoint levels in HCC. We validated the immune expression of ADRM1 in liver cancer cells using flow cytometry. In hepatocellular carcinoma tissues, miR‑891a‑5p regulatesADRM1. Upregulation of miR‑891a‑5p upregulatesADRM1, and downregulation of miR‑ 891a‑5p downregulatesADRM1. It is suggested that ADRM1 plays a key role in the occurrence and development of hepatocellular carcinoma. This study is expected to provide new ideas for the research and development of anti‑HCC drugs targeting miR‑891a‑5p/ADRM1 . However, further trials are needed to confirm these results and explore the actual results in patients with HCC. HCC is one of the most common malignant tumors in the world, ranking fourth in the world. It accounts for an alarming two million deaths annually, contributing to 4% of all global fatalities (1 out of every 25 deaths)1–3. HCC has a complex origin and involves various factors, such as viral infections, cirrhosis, excessive alcohol consumption, and immune system dysregulation playing a role4–6. Despite advancements in HCC diagnosis and treatment, significant challenges remain in its high mortality rate and unfavorable prognosis, primarily attributed to frequent recurrences and the spread of cancer to other parts of the body7. Liver cancer is mostly moderate and severe and is mainly treated by surgery at present, but there is no effective clinical method so far8,9. Liver cancer is one of the most common malignant tumors in China; therefore, there is an urgent need to identify anew mechanism for the occurrence and development of liver cancer. ADRM1 is a key molecule in the binding of 26s to its substrate and is a connexin of 26s10, 11. Previous studies have shown that ADRM1 regulates cell differentiation, migration, and adhesion. ADRM1 is a oncogenic factor that plays an important role in cancer12–17. ADRM1 is highly expressed in ovarian cancer cells and is closely associated with poor patient prognosis13. In addition, ADRM1 plays an important role in tumorigenesis and development15. Moreover, the transcription of ADRM1 has been shown to stimulate the growth of colorectal cancer16. In 2020, Liang reported elevated levels ofADRM1 expression is indicative of an unfavorable prognosis and can be suppressed by RA190 in HCC19. However, this study focused on the association between miRNA891a- 5p and the expression, prognosis, and molecular mechanism of action of ADRM1 in HCC and its relationship with immune infiltration of HCC remain unclear. Based on the ADRM1 gene, this study analyzed the relationship between ADRM1 expression in many types of tumor tissues and the prognosis of tumor patients. Based on this, we studied the relationship between the expression of ADRM1 in hepatocellular carcinoma and immune 1Department of General Surgery of the Second Affiliated Hospital of Xuzhou Medical University, No.32 of Meijian Road, Xuzhou 221000, Jiangsu Province, China. 2These authors contributed equally: Ziqi Shao and Yua

FAQs

What is the main relationship investigated in this study?

The study investigates how high ADRM1 expression is related to tumor immune infiltration and patient prognosis in hepatocellular carcinoma, and how this is regulated by miR-891a-5p.

How does miR-891a-5p affect ADRM1 expression in hepatocellular carcinoma?

miR-891a-5p regulates ADRM1 in hepatocellular carcinoma tissues: upregulation of miR-891a-5p increases ADRM1, while downregulation decreases ADRM1.

What evidence is used to assess ADRM1 and immune-related aspects?

The study validates immune expression of ADRM1 in liver cancer cells using flow cytometry, and analyzes relationships involving immune cell labeling and immune test sites.

Sep 21, 2026

Uploaded by Hazel