The Egyptian Journal of Internal Medicine - The prevalence of multiple organ dysfunction syndrome and its relationship with clinical variables in intensive care unit patients in Iran, 2022

Q: What was the purpose of this study in Iran in 2022?

To determine the prevalence of multi-organ dysfunction syndrome (MODS) and examine its relationship with clinical variables in ICU patients in Iran in 2022.

Q: How many ICU patients were included, and where were they recruited?

A total of 194 ICU patients were included, recruited from Kermanshah hospitals.

Q: Which clinical factors were significantly associated with MODS?

MODS was significantly related to factors including hospitalization and ICU duration, number of involved organs, Glasgow Coma Scale, PaO2, shock index, APACHE II score, SOFA score, mNUTRIC score, and free water deficit (P < 0.05).

Oct 4, 2026

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Hospitalization in intensive care units often leads to serious complications, including multi-organ dysfunction syndrome (MODS), which causes concurrent reversible physiological abnormalities across two or more organs. This cross-sectional descriptive-analytical study aimed to determine MODS prevalence and its association with clinical variables among 194 ICU patients from Kermanshah hospitals in Iran in 2022. Data were analyzed with SPSS-25 using multiple MODS- and severity-related metrics. Results showed a 56.2% prevalence with significant relationships to numerous clinical and severity indicators (P < 0.05).

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages11

Reading Time28 min

AccessFree to download

Abstract

Background

Methods

Results

Conclusion

Keywords

Background

Karami et al. The Egyptian Journal of Internal Medicine (2025) 37:1 [https://doi.org/10.1186/s43162-024-00390-w](https://doi.org/10.1186/s43162-024-00390-w) The Egyptian Journal of Internal Medicine RESEARCH Open Access The prevalence of multiple organ dysfunction syndrome and its relationship with clinical variables in intensive care unit patients in Iran, 2022 Arman Karami 1, Alireza Abdi1, Ali Akbar Vaisi Raygani 1*, Nader Salari2 and Mohammad Mehdi Mohammadi 1 Abstract Background Hospitalization in intensive care units (ICUs) often leads to complications. One such complication is multi-organ dysfunction syndrome (MODS) . This study aimed to determine the prevalence of MODS and its relationship with clinical variables in ICU patients in Iran, 2022. Methods This cross-sectional, descriptive-analytical study included 194 ICU patients from Kermanshah hospitals, selected between 30 April and 1 September 2022. Data collection tools included patient demographic forms, Marshall et al.’s MODS calculation formula (1995), shock index, mNUTRIC, SOFA, APACHE II, and free water deficit. Data were analyzed using the SPSS-25 software. Results The study found that 32% were aged 41–60, and 69. 6% were male. The average MODS score was 6.87 ± 1.59 (ranging from 0 to 24), with a prevalence of 56 . 2% . MODS was significantly related to clinical variables such as the number of days in the hospital, days in ICU, number of involved organs, Glasgow Coma Scale (GCS), partial pressure of oxygen (PaO2), shock index, APACHE II score, SOFA score, mNUTRIC score, and free water deficit (P < 0.05) . Conclusion MODS is highly prevalent among ICU patients. Key clinical factors associated with MODS include the duration of hospitalization, ICU stay, mechanical ventilation, number of involved organs, GCS, PaO2, shock index, APACHE II, SOFA, mNUTRIC, and free water deficit. Attention to these factors in clinical planning and management could be beneficial in addressing MODS in ICU patients. Keywords Intensive care unit, Multiple organ dysfunction syndrome, Patient Background Multiple organ dysfunction syndrome (MODS) is a severe condition characterized by reversible physiological abnormalities and the concurrent dysfunction of two or more organs. This syndrome significantly impacts patient *Correspondence: Ali Akbar Vaisi Raygani[vaisi20.a@gmail.com](vaisi20.a@gmail.com) 1 School of Nursing and Midwifery, Kermanshah University of Medical Sciences, Kermanshah, Iran 2 Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran outcomes, leading to prolonged intensive care unit (ICU) stays and a poorer prognosis. In the most severe cases, MODS is associated with a high mortality rate, ranging from 27 to 100% [1]. Recognized as a life-threatening condition, MODS necessitates comprehensive clinical management [2]. Early identification of MODS in highrisk patients within special care units is crucial for reducing mortality rates and preventing the progression to more severe states [3]. Patients with MODS not only face a higher risk of death but also tend to spend three times longer in the ICU and are more likely to require mechanical ventilation compared to those without the syndrome © The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the perm

FAQs

What was the purpose of this study in Iran in 2022?

To determine the prevalence of multi-organ dysfunction syndrome (MODS) and examine its relationship with clinical variables in ICU patients in Iran in 2022.

How many ICU patients were included, and where were they recruited?

A total of 194 ICU patients were included, recruited from Kermanshah hospitals.

Which clinical factors were significantly associated with MODS?

MODS was significantly related to factors including hospitalization and ICU duration, number of involved organs, Glasgow Coma Scale, PaO2, shock index, APACHE II score, SOFA score, mNUTRIC score, and free water deficit (P < 0.05).

Oct 4, 2026

Uploaded by jay