THE EFFECT OF ASTAXANTHIN ON FATIGUE IN DIABETIC PATIENTS - From a Nutritional Nursing Perspective

Q: What was the study objective regarding astaxanthin and diabetic fatigue?

To investigate how astaxanthin nutritional care affects diabetic fatigue in a type 2 diabetes mouse model over 12 weeks, emphasizing gut microbiota-related mechanisms.

Q: How was the diabetic mouse model established and how was fatigue measured?

A type 2 diabetes model was created using a 60% high-fat diet and low-dose streptozotocin injection; fatigue status was assessed using mouse running exhaustion tests.

Q: What key biochemical and microbiota-related changes did astaxanthin produce?

Astaxanthin reduced serum LPS and TMAO and modulated gut microbiota diversity by increasing beneficial genera and suppressing harmful genera, which were associated with improved fatigue and renal function.

Sep 29, 2026

Upload by moss~

Diabetic patients frequently experience elevated fatigue driven by inflammation, depression, and impaired glycemic control. Astaxanthin, known for anti-inflammatory and antioxidant activity, has demonstrated promise in animal studies, but mechanisms linked to nutritional nursing care remain unclear. This study tested astaxanthin nutritional intervention in a 12-week type 2 diabetes mouse model, assessing fatigue with exercise exhaustion tests and evaluating gut microbiota via 16S rRNA sequencing.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages1

Reading Time3 min

AccessFree to download

Background

Objective

Methodology

Animal model and intervention

Outcome assessments

Results

Discussion

Future directions

954 Innovation in Aging, 2025, Vol. 9, No. S2 Abstract citation ID: igaf122.3221 THE EFFECT OF ASTAXANTHIN ON FATIGUE IN DIABETIC PATIENTS FROM A NUTRITIONAL NURSING PERSPECTIVE Hongyu Li1, Rui Zhao2, Juan Li1, Guifang Guo3, and Wei Sang4, 1. Liaoning Polytechnic Vocational University, Jinzhou, Liaoning, China (People’s Republic), 2. Taizhou University, Faculty of Medicine, Taizhou, Zhejiang, China (People’s Republic), 3. Peking University, Beijing, Beijing, China (People’s Republic), 4. Zhejiang Houde Mingxin Technology Service Co., Taizhou, Zhejiang, China (People’s Republic) Background Diabetic patients often experience increased fatigue due to inflammation, depression, and poor glycemic control. Astaxanthin, with its anti-inflammatory and antioxidant properties, has shown potential in alleviating diabetic fatigue in animal studies. Objective We aimed to investigate the effects of astaxanthin nutritional care on diabetic fatigue in a type 2 diabetes mouse model over 12 weeks, focusing on gut microbiota-related mechanisms. Methodology A type 2 diabetes mouse model was established using a 60% high-fat diet and low-dose streptozotocin injection. Mouse running exhaustion tests assessed fatigue status. Astaxanthin was added to the diet at 0.01% and 0.02% for 12 weeks. Key fatigue indicators were compared before and after intervention and between groups. Gut microbiota was analyzed via 16S rRNA sequencing. Results The diabetes model group showed significantly higher fasting blood glucose (p <0.01), insulin (p=0.009), and insulin resistance index (p =0.002) than controls. Astaxanthin significantly reduced serum LPS (by 22.70% and 29.88%) and TMAO (by 33.82% and 28.57%). Gut microbiota diversity was modulated, with increased beneficial genera and suppressed harmful genera, influencing fatigue and renal function. Discussion The study demonstrated that increasing beneficial gut genera and inhibiting harmful genera effectively alleviated diabetic fatigue. Future research should explore long-term effects and human applications.: Astaxanthin, Nutrition nursing intervention, Diabetes fatigue, Gut flora

FAQs

What was the study objective regarding astaxanthin and diabetic fatigue?

To investigate how astaxanthin nutritional care affects diabetic fatigue in a type 2 diabetes mouse model over 12 weeks, emphasizing gut microbiota-related mechanisms.

How was the diabetic mouse model established and how was fatigue measured?

A type 2 diabetes model was created using a 60% high-fat diet and low-dose streptozotocin injection; fatigue status was assessed using mouse running exhaustion tests.

What key biochemical and microbiota-related changes did astaxanthin produce?

Astaxanthin reduced serum LPS and TMAO and modulated gut microbiota diversity by increasing beneficial genera and suppressing harmful genera, which were associated with improved fatigue and renal function.

Sep 29, 2026

Upload by moss~