The controlling nutritional status score as a new prognostic predictor in patients with cervical cancer receiving radiotherapy - propensity score matching analysis

Q: What was the goal of this study?

To examine whether the CONUT and mCONUT nutritional status scores have prognostic value for survival time in FIGO stage IIB–IIIB cervical cancer patients receiving radiotherapy.

Q: How were the optimal CONUT and mCONUT cut-off values determined?

Using receiver operating characteristic (ROC) curves in a retrospective analysis of 165 patients.

Q: What did the study find regarding CONUT and survival outcomes?

A CONUT score below the cut-off was associated with higher 5-year OS and PFS, while high CONUT predicted worse OS and PFS in Cox regression analyses.

Q: Did a high mCONUT score show the same prognostic effect as CONUT?

No. High mCONUT was not associated with decreased OS and PFS in the Cox regression results.

Sep 21, 2026

Uploaded by Asher

Background: CONUT and mCONUT nutritional status scores are linked to outcomes in multiple cancers. This study evaluated whether CONUT/mCONUT scores predict survival time in FIGO stage IIB–IIIB cervical cancer patients treated with radiotherapy. Methods: A retrospective cohort of 165 patients (2013–2015) determined optimal CONUT/mCONUT cut-offs via ROC curves. Propensity score matching reduced selection bias, and Kaplan–Meier and Cox models assessed prognostic performance; two nomograms were built for OS and PFS. Results: CONUT and mCONUT cut-offs were 2. Low CONUT showed higher 5-year OS and PFS, while high CONUT reduced OS and PFS; high mCONUT showed no significant Cox associations. Conclusion: CONUT is a promising survival predictor in this setting.

LanguageEnglish

CategoryResearch & Report

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Pages10

Reading Time25 min

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Abstract

Background

Methods

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Background

Fu etal. BMC Cancer (2024) 24:1093 BMC Cancer [https://doi.org/10.1186/s12885-024-12872-9](https://doi.org/10.1186/s12885-024-12872-9) RESEARCH Open Access The controlling nutritional status score as a new prognostic predictor in patients with cervical cancer receiving radiotherapy: a propensity score matching analysis Juan Fu 1†, Xintian Xu2†, Mengxing Tian3, Hongbing Wang4 and Xin Jin3* Abstract Background As assessment tools of nutritional status, the controlling nutritional status (CONUT) and modified controlling nutritional status (mCONUT) score are associated with survival in various cancers. We aimed to investigate the association between the CONUT/mCONUT score’s prognostic value and survival time in patients with FIGO stage IIB–IIIB cervical cancer treated with radiotherapy. Methods In this retrospective study, 165 patients between September 2013 and September 2015 were analyzed, and the optimal CONUT/mCONUT score cut-off values were determined using receiver operating characteristic curves. Propensity score matching (PSM) was used to minimize selection bias. The Kaplan–Meier method and a Cox proportional hazard model were used to assess the CONUT/mCONUT score’s predictive value linked to survival time. Two nomograms were created to predict the overall survival (OS) and progression-free survival (PFS) . Results The cut-off values for CONUT and mCONUT score were both 2. Five-year OS and PFS rates were higher in a low CONUT score group than in a high CONUT score group (OS: 81 . 1% vs. 53. 8%, respectively, P < 0. 001; PFS: 76.4% vs. 48. 2%, respectively; P < 0. 001) . A high CONUT score was associated with decreased OS (hazard ratio (HR) 2. 93, 95% CI 1.54–5. 56; P = 0 . 001) and PFS (HR 2 . 77, 95% CI 1.52–5. 04; P < 0. 001) . High CONUT scores influenced OS in the PSM cohort. A high mCONUT score was not associated with decreased OS and PFS in Cox regression analysis. Conclusion The CONUT score is a promising indicator for predicting survival in patients with cervical cancer receiving radiotherapy. Keywords Cervical cancer, Controlling nutritional status score, CONUT, Radiotherapy, Survival time †Juan Fu and Xintian Xu contributed equally to this work and share the first authorship. *Correspondence: Xin Jin [jinxinrd@alumni.hust.edu.cn](jinxinrd@alumni.hust.edu.cn) 1Department of Clinical Nutrition, Wuhan Third Hospital, Tongren Hospital of Wuhan University, Wuhan, China 2Department of Pharmacy, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China 3Department of Clinical Nutrition, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China 4Department of Gynecology and Oncology, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China © The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://](http://)[ ](http://)[creativecommons.org/l](creativecommons.org/l)icenses/by-nc-nd/4.0/. Fu et

FAQs

What was the goal of this study?

To examine whether the CONUT and mCONUT nutritional status scores have prognostic value for survival time in FIGO stage IIB–IIIB cervical cancer patients receiving radiotherapy.

How were the optimal CONUT and mCONUT cut-off values determined?

Using receiver operating characteristic (ROC) curves in a retrospective analysis of 165 patients.

What did the study find regarding CONUT and survival outcomes?

A CONUT score below the cut-off was associated with higher 5-year OS and PFS, while high CONUT predicted worse OS and PFS in Cox regression analyses.

Did a high mCONUT score show the same prognostic effect as CONUT?

No. High mCONUT was not associated with decreased OS and PFS in the Cox regression results.

Sep 21, 2026

Uploaded by Asher