Tau PET load in early-and late-onset Alzheimer’s disease - Across-sectional and longitudinal comparison of the LEADS and ADNI cohorts

Sep 30, 2026

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Aim to quantify baseline and longitudinal differences in tau PET tracer binding between early-onset Alzheimer’s disease (EOAD) and late-onset Alzheimer’s disease (LOAD) using the LEADS and ADNI cohorts. Compare 18F-Flortaucipir binding in amyloid-beta PET-positive, cognitively impaired participants, and include cognitively normal controls for baseline comparison. Apply CenTauR pipeline processing and multivariate models for cross-sectional and mixed-effects models for longitudinal analyses, reporting stronger EOAD binding and faster tau accumulation independent of disease stage.

LanguageEnglish

CategoryHealthcare

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Abstract

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DOI: 10. 1002/alz70856_104867 BIOMARKERS PODIUM PRESENTATION NEUROIMAGING Tau PET load in early-and late-onset Alzheimer’s disease: Across-sectional and longitudinal comparison of the LEADS and ADNI cohorts Konstantinos Chiotis1 Ganna Blazhenets 1 Daniel R. Schonhaut 1 Julien Lagarde 1 David N. Soleimani-Meigooni 1 Piyush Maiti 1 Jiaxiuxiu Zhang 1 Ranjani Shankar 1 Alinda Amuiri 1 Salma Rocha 1 Dustin B. Hammers2 Ani Eloyan3 RobertA. Koeppe4 Maria C. Carrillo5 Brad Dickerson6 Liana G. Apostolova7, 8, 9 Renaud La Joie 1 Gil D. Rabinovici 1, 10 the Longitudinal Early-Onset Alzheimer’s Disease Study Consortium and the Alzheimer’s Disease Neuroimaging Initiative 1 Memory and Aging Center, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA 2 Indiana University School of Medicine, Indianapolis, IN, USA 3 Department of Biostatistics, Brown University, Providence, RI, USA 4 University of Michigan, Ann Arbor, MI, USA 5Alzheimer’s Association, Chicago, IL, USA 6 Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA 7 Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA 8 Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA 9 Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA 10 Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA Correspondence Konstantinos Chiotis, Memory and Aging Center, Weill Institute for Neurosciences, Abstract Background: We aimed to assess differences in baseline and longitudinal tau PET tracer binding between early-onset Alzheimer’s disease (EOAD) and late-onset Alzheimer’s disease (LOAD) in the LEADS andADNI cohorts, respectively. Method: We analyzed amyloid-beta PET-positive, cognitively impaired participants from the LEADS (EOAD; n = 383) and ADNI (LOAD; n = 196) cohorts with available 18 F-Flortaucipir tau PET data (Table 1). A subset had longitudinal 18 F-Flortaucipir PET data from LEADS (n = 232) and ADNI (n = 94) with average follow-up intervals of 1. 95 and 2.44 years, respectively. All 18 F-Flortaucipir PET scans were processed using the CenTauR pipeline. Cognitively normal participants from LEADS (n = 94) and ADNI (n = 421) with baseline 18 F-Flortaucipir and amyloid-beta PET scans were also analyzed for comparison. We performed EOAD vs. LOAD comparisons using multivariate linear and linear mixed-effects models for cross-sectional and longitudinal analyses, respectively. Result: Baseline comparisons revealed large effect-size, significant differences in 18 FFlortaucipir binding between EOAD and LOAD (Figure 1). EOAD participants had higher 18 F-Flortaucipir levels in widespread neocortical regions compared to LOAD, after adjusting for covariates. In both groups, tau load was negatively associated with age. In EOAD, a significantly steeper slope was found in the association between This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2025 The Alzheimer’s Association. Alzheimer’s & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer’s Association. Alzheimer’s Dement. 2025;21(Suppl. 2):e104867. [https://doi.org/10.1002/alz70856_104867](https://doi.org/10.1002/alz70856_104867) wi[leyonlinelibrary.com/journal/alz](leyonlinelibrary.com/journal/alz) 1of4 University of California San Francisco, San Francisco, CA, USA. [Email:](Email: Konstantinos.chiotis@ucsf.edu)[ Konstantinos.chiotis@ucsf.edu](Email: Konstantinos.chiotis@ucsf.edu) amyloid-beta and 18 F-Flortaucipir load, as well as between cognitive scores and 18 FFlortaucipir load. Longitudinally, EOAD

FAQs

What was the primary goal of the study?

To assess baseline and longitudinal differences in tau PET tracer binding between early-onset and late-onset Alzheimer’s disease using the LEADS and ADNI cohorts.

Which PET tracer and participant groups were analyzed?

The study analyzed amyloid-beta PET-positive, cognitively impaired participants with available 18F-Flortaucipir tau PET data from LEADS (EOAD) and ADNI (LOAD), and it also examined cognitively normal participants from both cohorts for baseline comparisons.

What key differences were found between EOAD and LOAD?

EOAD showed significantly higher 18F-Flortaucipir binding across widespread neocortical regions at baseline and a faster increase in tau binding over time, with an association of tau load negatively with age in both groups.

Sep 30, 2026

Uploaded by Aran