Targeted variant prevalence of FBXW7 gene mutation in colorectal carcinoma propagation - The first systematic review and meta-analysis

Q: What does FBXW7 do and why is its mutation important in colorectal cancer?

FBXW7 is a tumor suppressor gene acting as an E3-ubiquitin ligase that targets several oncoproteins for degradation and regulates cell cycle progression. Mutations are frequently implicated in cancers, including colorectal carcinoma.

Q: How were studies selected for the systematic review and meta-analysis?

The review followed PRISMA criteria and was registered with PROSPERO (CRD42023388845). From 1182 preliminary records, 58 eligible studies were included after excluding non-eligible studies.

Q: What was the main finding on the prevalence of FBXW7 mutations?

The meta-analysis included 13,974 respondents and estimated an overall FBXW7 mutation prevalence of 10.3% (95% CI: 8.6–12.4) with high heterogeneity (I2 = 90.5%).

Q: Which patient or tumor factors showed higher mutation prevalence?

Higher prevalence was reported across several subgroups, including male gender and later tumor stages. Tumor location and site (colon, left) and tumor grade (moderate) were also associated with notable prevalence differences.

Sep 21, 2026

Uploaded by Ivy

FBXW7 is a tumor suppressor gene functioning as an E3-ubiquitin ligase that regulates degradation of key oncoproteins (Cyclin-E, c-Myc, Notch) and controls cell cycle progression. FBXW7 mutations are frequently linked to multiple cancers, prompting a systematic review and meta-analysis. Studies were screened using PRISMA criteria and registered with PROSPERO (CRD42023388845), yielding 58 eligible datasets from an initial 1182 records. Prevalence estimates were analyzed with OpenMeta Analyst and CMA-3.0 software.

LanguageEnglish

CategoryResearch & Report

FormatPDF

Pages16

Reading Time40 min

AccessFree to download

Introduction

Background

Methodology

Search strategy and study selection

Results

Overall prevalence and subgroup findings

Conclusion

Heliyon 10 (2024) e31471 Contents lists available at ScienceDirect Heliyon journal [homepage:](homepage: www.cell.com/heliyon)[ www.cell.com/heliyon](homepage: www.cell.com/heliyon) Research article Targeted variant prevalence ofFBXW7 gene mutation in colorectal carcinoma propagation. The first systematic review and meta-analysis Hafeez Abiola Afolabi a, Salzihan Md Sallehb, *, Zaidi Zakariaa, Ch’ng Ewe Sengh, Norasikin Mohd Nafii, Ahmad Aizat Bin AbdulAziz c, Yusuf Wadad, g, Ahmad Adebayo Irekeolad, Sameer Badri Al-Ml-hanna e, Ali Mussaf,j a Department of General Surgery, School of Medical Sciences, Hospital Universiti Sains Malaysia (HUSM), Health Campus, Universiti Sains Malaysia (USM), Kubang Kerian, Kelantan, 16150, Malaysia b Department of Pathology, School of Medical Sciences, Hospital Universiti Sains Malaysia (HUSM), Health Campus, Universiti Sains Malaysia (USM), Kubang Kerian, 16150, Kelantan, Malaysia c Department of Human Genome Centre, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, 16150, Kelantan, Malaysia d Department of Medical Microbiology and Parasitology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, 16150, Kelantan, Malaysia e Department of Exercise Physiology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, 16150, Kelantan, Malaysia f Department of Biology, Faculty of Education, Omdurman Islamic University, Omdurman, P.O. Box 382, Sudan g Department of Zoology, Ahmadu Bello University, Zaria, Kaduna, Nigeria h Department of Pathology, Advanced Medical & Dental Institute, Universiti Sains Malaysia (USM), Kepala Batas, 13200, Malaysia i Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia (USM), Health Campus, Kubang Kerian, 16150, Malaysia j Department of Haematology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150, Kelantan, Malaysia A R T I C L E I N F O Keywords: Colon cancer Colorectal carcinoma CRC FBXW7 gene mutation A B S T R A C T FBXW7 is a tumour suppressor gene that functions as E3-ubiquitin-ligase, targeting numerous oncoproteins for degradation, i.e., Cyclin-E, c-Myc, and Notch. FBXW7 performs a pivotal role in regulating cell cycle progression. FBXW7 mutation is frequently implicated in various cancers. Methodology: A systematic review and meta-analysis done on several studies using “Preferred Reporting Items for Systemmatic Reviews and Meta-Analysis (PRISMA)” criteria and registered with PROSPERO (registration-number-CRD42023388845). The preliminary search comprises 1182 articles; however, 58 studies were subsequently chosen after eliminating non-eligible studies. To explore the prevalence of FBXW7 mutation among colorectal cancer patients, data were analysed using “OpenMeta Analyst and comprehensive meta-analysis-3.0 (CMA-3.0)”software. Results: This meta-analysis involves 13,974 respondents; most were males 7825/13,974,(56.0 %). Overall prevalence of FBXW7 mutations was 10.3 %,(95%CI: 8.6–12.4), I2 = 90.5 %,(P < 0.001). The occurrence of FBXW7 mutations was highest in Russia [19.0 %,(95%CI: 9.8–33.7)] * Corresponding author. E-mail addresses: [afolabihafeez68@gmail.com](afolabihafeez68@gmail.com) (H.A. Afolabi), [profsalzihan66@gmail.com](profsalzihan66@gmail.com), [salzihan@usm.my](salzihan@usm.my) (S.M. Salleh), doczakaria44@ [gmail.com](gmail.com), [drzaidi@usm.my](drzaidi@usm.my) (Z. Zakaria), [eschng@usm.my](eschng@usm.my) (C.E. Seng), [snmn@usm.my](snmn@usm.my) (N.M. Nafi), [aizataziz@usm.my](aizataziz@usm.my) (A.A. Bin AbdulAziz), [wadayusuf34@gmail.com](wadayusuf34@gmail.com), [wadayusuf@student.usm.my](wadayusuf@student.usm.my) (Y. Wada), [profahmad007@yahoo.com](profahmad007@yahoo.com) (A.A. Irekeola), [sameerbadri9@gmail.com](sameerbadri9@gmail.com) (S.B. Al-Ml-hanna), [alimaha1341989@gmail.com](alimaha1341989@gmail.com) (A. Mussa). [https://doi.org/10.1016/j

FAQs

What does FBXW7 do and why is its mutation important in colorectal cancer?

FBXW7 is a tumor suppressor gene acting as an E3-ubiquitin ligase that targets several oncoproteins for degradation and regulates cell cycle progression. Mutations are frequently implicated in cancers, including colorectal carcinoma.

How were studies selected for the systematic review and meta-analysis?

The review followed PRISMA criteria and was registered with PROSPERO (CRD42023388845). From 1182 preliminary records, 58 eligible studies were included after excluding non-eligible studies.

What was the main finding on the prevalence of FBXW7 mutations?

The meta-analysis included 13,974 respondents and estimated an overall FBXW7 mutation prevalence of 10.3% (95% CI: 8.6–12.4) with high heterogeneity (I2 = 90.5%).

Which patient or tumor factors showed higher mutation prevalence?

Higher prevalence was reported across several subgroups, including male gender and later tumor stages. Tumor location and site (colon, left) and tumor grade (moderate) were also associated with notable prevalence differences.

Sep 21, 2026

Uploaded by Ivy