Synchronous multiple primary malignant neoplasms in breast, kidney, and bilateral thyroid - A case report

Sep 24, 2026

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Multiple primary malignant neoplasms (MPMNs) are rare, and synchronous MPMNs are even less common. As medical technology advances and life expectancy increases, the incidence is gradually rising. While breast and thyroid dual cancers are frequently reported, additional kidney primary cancer diagnosed in the same individual is uncommon. A case is presented of simultaneous MPMN involving three endocrine organs, with literature review to support accurate diagnosis and multidisciplinary management.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages9

Reading Time23 min

AccessFree to download

Abstract

Background

Case summary

Conclusion

Introduction

Case presentation

Chief complaints

History of present illness

History of past illness

Personal and family history

Physical examination

Core tip

| W | J | C | C | World Journal of
Clinical Cases | | --- | --- | --- | --- | --- | Submit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Clin Cases 2023 March 6; 11(7): 1513-1520 DOI: 10.12998/wjcc.v11.i7.1513 ISSN 2307-8960 (online) CASE REPORT Synchronous multiple primary malignant neoplasms in breast, kidney, and bilateral thyroid: A case report Miao-Miao Jia, Bin Yang, Chao Ding, Ya-Rong Yao, Jun Guo, Hai-Bo Yang Specialty type: Medicine, research and experimental Provenance and peer review: Unsolicited article; Externally peer reviewed. Peer-review model: Single blind Peer-review report’s scientific quality classification Grade A (Excellent): 0 Grade B (Very good): B Grade C (Good): C Grade D (Fair): 0 Grade E (Poor): 0 P-Reviewer: Dimofte GM, Romania; Mehdipour P, Iran Received: October 24, 2022 Peer-review started: October 24, 2022 First decision: January 20, 2023 Revised: February 2, 2023 Accepted: February 15, 2023 Article in press: February 15, 2023 Published online: March 6, 2023 Miao-Miao Jia, Bin Yang, Chao Ding, Ya-Rong Yao, Jun Guo, Hai-Bo Yang, Department of General Surgery, Shanxi Bethune Hospital/General Surgery Department, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan 030032, Shanxi Province, China Corresponding author: Hai-Bo Yang, Doctor, Surgeon, Department of General Surgery, Shanxi Bethune Hospital/General Surgery Department, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, No. 99 Longcheng Street, Taiyuan 030032, Shanxi Province, [China.](China. yanghb2006460@126.com)[ yanghb2006460@126.com](China. yanghb2006460@126.com) Abstract BACKGROUND Multiple primary malignant neoplasms (MPMNs) are rare, while synchronous MPMNs (SMPMNs) are even less common. Owing to the progression of medical technology and the extension of life expectancy, its incidence is gradually increasing. CASE SUMMARY Although reports of breast and thyroid dual cancers are common, cases of an additional diagnosis of kidney primary cancer within the same individual are rare. CONCLUSION We present a case of simultaneous MPMN of three endocrine organs, reviewing the relevant literature to enhance our understanding of SMPMNs while emphasizing the increasingly important need for accurate diagnosis and multidisciplinary management whenever this challenging situation arises. Key Words: Synchronous; Multiple primary malignant neoplasms; Breast cancer; Kidney cancer; Bilateral thyroid cancer; Tumor neoplasm; Case report ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. WJCC [https://www.wjgnet.com](https://www.wjgnet.com) 1513 March 6, 2023 Volume 11 Issue 7 Jia MM et al. Multiple primary malignant neoplasms Core Tip: Multiple primary malignant neoplasms (MPMNs) are rare, while synchronous MPMNs are even less common. Owing to the progression of medical technology and the extension of life expectancy, its incidence is gradually increasing. Although reports of breast and thyroid dual cancers are common, cases of an additional diagnosis of kidney primary cancer within the same individual are rare. Citation: Jia MM, Yang B, Ding C, Yao YR, Guo J, Yang HB. Synchronous multiple primary malignant neoplasms in breast, kidney, and bilateral thyroid: A case report. World J Clin Cases 2023; 11(7): 1513-1520 URL: [https://www.wjgnet.com/2307-8960/full/v11/i7/1513.htm](https://www.wjgnet.com/2307-8960/full/v11/i7/1513.htm) DOI: [https://dx.doi.org/10.12998/wjcc.v11.i7.1513](https://dx.doi.org/10.12998/wjcc.v11.i7.1513) INTRODUCTION Multiple primary malignant neoplasms (MPMNs) are generally defined as the occurrence of two or more pathologically diagnosed primary malignant tumors in ≥ 1 organ or tissue in the same person[1] . Although inconsistent among various studies, an a

FAQs

What are synchronous multiple primary malignant neoplasms (SMPMNs)?

SMPMNs refer to two or more pathologically diagnosed primary malignant tumors occurring within six months of the primary tumor diagnosis in the same person.

Why is the reported case clinically notable?

Reports of breast and thyroid dual cancers are common, but an additional diagnosis of a kidney primary cancer in the same individual is rare.

What does the conclusion emphasize for patient management?

Accurate diagnosis and multidisciplinary management are increasingly important when dealing with this challenging situation involving multiple endocrine organs.

Sep 24, 2026

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