Surface functionalized nanomaterial systems for targeted therapy of endocrine related tumors - a review of recent advancements

Sep 21, 2026

Uploaded by Ezra

Endocrine-related cancers require coordinated multidisciplinary management, yet malignant cells develop resistance to conventional chemotherapy and radiotherapy, leaving overall survival unsatisfactory. Recent therapeutic advances provide new directions for treating diverse endocrine tumors. This review evaluates nano-drug delivery advances and nanomaterial-enabled targeted therapy for thyroid cancer, adrenal gland tumors, and pancreatic cancer. It also highlights how engineering synthetic or natural substances into nanoparticles can enhance intracellular uptake, reduce endocrine malignancy progression, and inform development of new DDS strategies.

LanguageEnglish

CategoryResearch & Report

FormatPDF

Pages18

Reading Time45 min

AccessFree to download

Introduction

Functionalized nanomaterials and targeted therapy overview

Endocrine tumor background

Thyroid cancer epidemiology and risk factors

Parathyroid and other endocrine tumor considerations

Drug Delivery 2024, vOl. 31, NO. 1, 2390022 [https://doi.org/10.1080/10717544.2024.2390022](https://doi.org/10.1080/10717544.2024.2390022) Review ARticle Surface functionalized nanomaterial systems for targeted therapy of endocrine related tumors: a review of recent advancements limei liua*, Miao Yanga* and Ziyang chenb aDepartment of endocrinology, Sichuan Provincial People’s Hospital, School of Medicine, university of electronic Science and Technology of China, Chengdu, China; bDepartment of gastroenterology, Sichuan Provincial People’s Hospital, School of Medicine, university of electronic Science and Technology of China, Chengdu, China ABSTRACT the application of multidisciplinary techniques in the management of endocrine-related cancers is crucial for harnessing the advantages of multiple disciplines and their coordinated efforts in eliminating tumors. Due to the malignant characteristics of cancer cells, they possess the capacity to develop resistance to traditional treatments such as chemotherapy and radiotherapy. Nevertheless, despite diligent endeavors to enhance the prediction of outcomes, the overall survival rate for individuals afflicted with endocrine-related malignancy remains quite miserable. Hence, it is imperative to investigate innovative therapy strategies. the latest advancements in therapeutic tactics have offered novel approaches for the therapy of various endocrine tumors. this paper examines the advancements in nano-drug delivery techniques and the utilization of nanomaterials for precise cancer cures through targeted therapy. this review provides a thorough analysis of the potential of combined drug delivery strategies in the treatment of thyroid cancer, adrenal gland tumors, and pancreatic cancer. the objective of this study is to gain a deeper understanding of current therapeutic approaches, stimulate the development of new drug DDS, and improve the effectiveness of treatment for patients with these diseases. the intracellular uptake of pharmaceuticals into cancer cells can be significantly improved through the implantation of synthetic or natural substances into nanoparticles, resulting in a substantial reduction in the development of endocrine malignancies. GRAPHICAL ABSTRACT ARTICLE HISTORY Received 19 March 2024 Revised 3 June 2024 Accepted 23 July 2024 KEYWORDS Functionalizednanomaterials; endocrine related tumors; thyroid cancer; adrenal gland cancer; pancreatic cancer; nanocarriers; targeted therapy 1. Introduction endocrine tumors often result in disruptions in hormone production, occasionally leading to distinct hormonal disorders. Malignant tumors can be found in several endocrine glands, such as the thyroid, adrenal, pancreatic, parathyroid, and pituitary glands. while certain cancers are uncommon, they can exhibit significant death rates. Generally, any sign of metastasis suggests a poor prognosis, having a high likelihood of recurrence and a limited response to therapies (Schulte et al., 2012; wong et al., 2014; Scollo et al., 2016) . thyroid carcinoma is the predominant form of endocrine cancer, primarily impacting 77% women. Based on the SeeR (Surveillance, epidemiology and end Results Program), around 56,000 new instances of tumors in the thyroid were projected in 2016, constituting 3.8% of all newly diagnosed cancer cases (Ferlay et al., 2015; lima et al., 2017) . the incidence of CONTACT Ziyang Chen [13981791891@163.com](13981791891@163.com) Department of gastroenterology, Sichuan Provincial People’s Hospital, School of Medicine, university of electronic Science and Technology of China, Chengdu 611731, China *The authors have equal contributions to the study. © 2024 The Author(s) . Published by informa uK limited, trading as Taylor & Francis group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial license ([http://creativecommons.org/licenses/by-nc/4.0/](http://creativecommons.o

FAQs

Why is targeted nano-drug delivery important for endocrine-related cancers?

Malignant endocrine tumor cells can resist chemotherapy and radiotherapy. Nano-drug delivery aims to improve precision and enhance drug performance for more effective treatment.

Which endocrine tumor types does the review focus on?

The review analyzes targeted therapy and combined drug delivery strategies for thyroid cancer, adrenal gland tumors, and pancreatic cancer.

How do functionalized nanoparticles help improve anticancer effects?

By implanting synthetic or natural substances into nanoparticles, intracellular uptake into cancer cells can be significantly improved, supporting reductions in endocrine malignancy development.

Sep 21, 2026

Uploaded by Ezra