Successful delivery after in vitro fertilization - embryo transfer in a woman with metachronous primary cancer of ovary and endometrium - a case report

Sep 24, 2026

Uploaded by Terk

Management of fertility in patients with double primary gynecological malignancies remains challenging because relatively few cases describe coordinated oncologic and reproductive strategies. This case report addresses dual primary ovarian and endometrial cancers, focusing on individualized ovulation induction approaches and key pregnancy and delivery considerations. A 39-year-old woman with infertility achieved conception after three ovulation induction protocols and delivered a healthy infant at 33 weeks via caesarean section.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages10

Reading Time25 min

AccessFree to download

Abstract

Background

Case presentation

Conclusions

Keywords

Tian et al. BMC Pregnancy and Childbirth (2023) 23:677 [https://doi.org/10.1186/s12884-023-05973-z](https://doi.org/10.1186/s12884-023-05973-z) BMC Pregnancy and Childbirth CASE REPORT Open Access Successful delivery after in vitro fertilization-embryo transfer in a woman with metachronous primary cancer of ovary and endometrium: a case report Yichang Tian 1,2, Yu Liang 1,2* and Xiaokui Yang 1,2* Abstract Background The appearance of malignancies at various times in the same individual, excluding metastases of the initial primary cancer, is termed multiple primary cancers. Double primary gynecological cancers cause inevitable damage to female reproductive function, and the preservation of fertility in such patients remains a challenging issue as relatively few cases have been reported. This case report provides management options for dual primary ovarian and endometrial cancers, including the choice of ovulation induction protocols, considerations during pregnancy and parturition, with the aim of providing assistance to clinicians. Case presentation We report a case of a 39-year-old woman with primary infertility and a medical history of rightsided ovarian mucinous borderline tumor with intraepithelial carcinoma, left-sided ovarian mucinous cystadenoma and endometrial cancer, who successfully conceived with in vitro fertilization-embryo transfer (IVF-ET) after three different ovulation induction protocols. During her pregnancy, she was complicated by central placenta praevia with placental implantation and eventually delivered a healthy female infant by caesarean section at 33 gestational weeks. Conclusions For patients with double primary gynecological cancers who have an intense desire for fertility, the most appropriate oncological treatment should be applied according to the patient’s individual situation, and fertility preservation should be performed promptly. Ovulation induction protocol should be individualized and deliberate, with the aim of ensuring that the patient’s hormone levels do not precipitate a recurrence of the primary disease during induction of ovulation and maximizing fertility outcomes. In addition, the risk of postpartum hemorrhage due to placental factors cannot be neglected in such patients. Keywords Endometrial cancer, Intraepithelial carcinoma, Placenta previa, Placenta accreta spectrum, In vitro fertilization-embryo transfer (IVF-ET), Case report *Correspondence: Yu Liang [liangyu1981830@163.com](liangyu1981830@163.com)[ ](liangyu1981830@163.com)Xiaokui Yang [yangxiaokui@ccmu.edu.cn](yangxiaokui@ccmu.edu.cn) 1Department of Human Reproductive Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China 2Beijing Maternal and Child Health Care Hospital, Beijing, China © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creativecommons.org/l](http://creativecommons.org/l)icenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ([http://creativecommons.org/publicdomain/zero/1.0/](http://creativecommons.org/publicdomain/zero/1.0/)) applies to the data made available in this article, unless otherwise stated in a credit line to the data. Tian et al. BMC Pregnancy

FAQs

What does the report define as multiple primary cancers?

Multiple primary cancers are two or more malignancies occurring in the same individual, where the later cancer is not metastasis of the initial primary tumor.

What fertility preservation approach was used in the case?

Fertility preservation was pursued with in vitro fertilization-embryo transfer (IVF-ET) after selecting among three different ovulation induction protocols.

How was the pregnancy and delivery managed and what was the outcome?

The pregnancy was complicated by central placenta praevia with placental implantation, and a healthy female infant was delivered by caesarean section at 33 gestational weeks.

Sep 24, 2026

Uploaded by Terk