Study on the Postprandial Blood Glucose Suppression Effect of D-Psicose in Borderline Diabetes and the Safety of Long-Term Ingestion by Normal Human Subjects

Q: What was the purpose of this clinical study?

To evaluate the safety and effect of D-psicose on postprandial blood glucose levels in adults, including borderline diabetes patients.

Q: How did the study test the effect of D-psicose after a meal?

It used a randomized double-blind placebo-controlled crossover design where 26 subjects ingested either 0 g or 5 g D-psicose with a standard meal, and glucose was measured at fasting and 30, 60, 90, and 120 minutes.

Q: What did the long-term ingestion trial show about safety?

In 17 normal subjects taking 5 g D-psicose or D-glucose with meals three times daily for 12 weeks, no abnormal effects or clinical problems caused by continuous D-psicose ingestion were observed.

Jul 10, 2026

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Clinical investigation evaluates the safety and glucose-lowering effect of D-psicose on postprandial blood glucose in adult men and women, including individuals with borderline diabetes. A randomized double-blind placebo-controlled crossover study assessed single 0 g or 5 g ingestion with a standard meal, measuring fasting and 30–120 min glucose; D-psicose significantly lowered glucose at 30 and 60 min and reduced the AUC. Long-term safety was tested in normal subjects over 12 weeks with 5 g D-psicose or D-glucose taken thrice daily, showing no abnormal effects or clinical problems.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages10

Reading Time25 min

Background and rationale

Rationale for controlling postprandial glucose

D-Psicose characteristics and prior evidence

Study design and methods

Single-ingestion crossover trial

Long-term ingestion parallel trial

Results and findings

Postprandial glucose suppression

Long-term safety outcomes

Safety considerations and clinical implications

Biosci. Biotechnol. Biochem., 74 (3), 510–519, 2010 Study on the Postprandial Blood Glucose Suppression Eﬀect of D-Psicosein Borderline Diabetes and the Safety of Long-Term Ingestion by Normal Human Subjects Noriko HAYASHI, 1; y Tetsuo IIDA, 1 Takako YAMADA, 1 Kazuhiro OKUMA, 1 Isao TAKEHARA,2 Takashi YAMAMOTO,3 Koji YAMADA,4 and Masaaki TOKUDA5 1Research and Development, Matsutani Chemical Industry Co., Ltd., 5-3 Kita-Itami, Itami, Hyogo 664-8508, Japan 2New Drug Development Research Center, Inc., 452-1 Toiso, Eniwa, Hokkaido 061-1405, Japan 3AIEIsupport Ltd., 2-9 Ono, Itami, Hyogo 664-0003, Japan 4Rare Sugar Foods LLC, 307 Minatomachi, Marugame, Kagawa 763-0042, Japan 5Department of Cell Physiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kagawa 761-0793, Japan Received September 29, 2009; Accepted December 11, 2009; Online Publication, March 7, 2010 [doi:10.1271/bbb.90707] This clinical study was conducted to investigate the safety and eﬀect of D-psicose on postprandial blood glucose levels in adult men and women, including borderline diabetes patients. A randomized doubleblind placebo-controlled crossover experiment of single ingestion was conducted on 26 subjects who consumed zero or 5 g of D-psicose in tea with a standard meal. The blood glucose levels at fasting and 30, 60, 90, and 120 min after the meal were compared. The blood glucose level was signiﬁcantly lower 30 and 60 min after the meal with D-psicose (p < 0:01, p < 0:05), and asigniﬁcant decrease was also shown in the area under the curve (p < 0:01). The results suggest that D-psicose had an eﬀect to suppress the postprandial blood glucose elevation mainly in borderline diabetes cases. A randomized double-blind placebo-controlled parallelgroup experiment of long-term ingestion was conducted on 17 normal subjects who took 5 g of D-psicose or D-glucose with meals three times a day for 12 continuous weeks. Neither any abnormal eﬀects nor clinical problems caused by the continuous ingestion of D-psicose were found. Key words: D-psicose; sweetener; blood glucose; human; safety Preventing and improving the metabolic syndromes associated with rapidly increasing dyslipidemia and hyperglycemia are urgent matters to resolve for reducing medical costs that have been rising in recent years. In particular, diabetes tends to accompany such complications as retinopathy, nephropathy and neuropathy; medical costs therefore increase, making it very important to reduce the disease. 1) Preventing and improving diabetes are based on correcting life-style habits. Above all, it is important to control blood glucose levels after a meal, and a number of studies are in progress to ﬁnd dietary factors that can suppress blood glucose elevation by using the glycemic index.2–4) D-Psicose (D-ribo-2-hexulose, CAS registration number 551-68-8, molecular formula C6H 12 O6 , molecular weight 180.156) is a C-3 epimer of D-fructose and is oneof the monosaccharides, a rare sugar, that are rarely found in nature. Matsuo et al. have clariﬁed the glucose suppression eﬀect of D-psicose by animal experiments. They showed an inhibition capability of 􀀁-glucosidasein the suppression mechanism and presumed that the compound had similar behavior to D-fructose in its glucose uptake from liver.5–7) Moreover, we have previously conducted a glucose loading experiment on healthy adults using a starch hydrolysate (glucose solution) as the carbohydrate source.8) The results showed that approximately 5 g of D-psicose to 75 g of carbohydrate signiﬁcantly suppressed the blood glucose elevation. Approximately 1 part of D-psicose was eﬀective to 15 parts of carbohydrate ingested. It was also conﬁrmed that a single ingestion of D-psicose had no eﬀect on the blood glucose and insulin levels, meaning that hypoglycemia would not be induced by D-psicose. Those studies showed that D-psicose had aneﬀect of suppressing the postprandial blood glucose elevation. However, from the

FAQs

What was the purpose of this clinical study?

To evaluate the safety and effect of D-psicose on postprandial blood glucose levels in adults, including borderline diabetes patients.

How did the study test the effect of D-psicose after a meal?

It used a randomized double-blind placebo-controlled crossover design where 26 subjects ingested either 0 g or 5 g D-psicose with a standard meal, and glucose was measured at fasting and 30, 60, 90, and 120 minutes.

What did the long-term ingestion trial show about safety?

In 17 normal subjects taking 5 g D-psicose or D-glucose with meals three times daily for 12 weeks, no abnormal effects or clinical problems caused by continuous D-psicose ingestion were observed.

Jul 10, 2026

Upload by Patrick