Study of the Relationship between ABO Blood Group Types and Breast Cancer and Cervix Cancer in Khuzestan Province, Iran

Sep 24, 2026

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Breast cancer and cervix cancer are widespread solid tumors with high mortality, making identification of predisposing risk factors essential for prevention and management. Prior research suggests ABO and Rh blood-group systems may influence cancer susceptibility and clinical features. This retrospective study evaluated ABO and Rh blood groups as risk factors for breast cancer and cervix cancer in Khuzestan, Iran, using patient data and donor distribution information.

LanguageEnglish

CategoryResearch & Report

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Pages10

Reading Time25 min

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Abstract

Introduction

Study of the Relationship between ABO Blood Group Types and Breast Cancer and Cervix Cancer in Khuzestan Province, Iran Nazanin Joudaki1,2,3, Ali Khodadadi1,4, Abdolhassan Talaiezadeh4,5, Hosein Jodat2, Javad Jodat2, Ali Asadirad1 1Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran 2Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran 3Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran 4Cancer, Petroleum and Environmental Pollutants Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran 5 Department of Surgery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Corresponding Author: Ali Asadirad, Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran E-mail: [ali.asadirad@gmail.com](ali.asadirad@gmail.com) Received: 13, Dec, 2021 Accepted: 18, Oct, 2022 ABSTRACT Background: Breast cancer and cervix cancer are the prevalent and deadly types of solid tumors around the world. According to the importance of cancer, it is necessary to understand predisposing factors that affect cancer risk. In this regard, previous studies suggest that blood types particularly ABO and Rh-Hr Blood-Group System could play roles in the risk and different features of cancers. In the present study, we aimed to evaluate the potential of ABO and Rh blood groups as risk factors for breast cancer and cervix cancer. Materials and Methods: A retrospective study included 109 and 14 patients diagnosed with breast cancer and cervix cancer, respectively with known ABO and Rh blood types, between 2018 and 2020 in Khuzestan province, Iran. For compression of ABO blood groups distribution between the cancer patients group and the healthy population, we used data from a large-scale study that report the distribution of ABO blood groups in 29,922 blood donors in Khuzestan province. Results: Based on obtained results the most frequent blood group is O followed by B, A, and AB in breast cancer and followed by A, B, and AB in cervix cancer. Results showed no significant association between ABO and Rhand the risk of breast and cervix cancer. Moreover, there is no relationship between blood types and clinic pathological features of breast cancer. Conclusion: Based on our data, ABO and in this regard, previous studies suggest that blood types particularly ABO and Rh-Hr Blood-Group System could play roles in the risk and different features of cancers. In the present study, we aimed to evaluate the potential of ABO and Rh blood groups as risk factors for breast cancer and cervix cancer do have not any association with the risk of breast and cervix cancer and their characteristics. Keywords: ABO blood-group system; Rh-Hr bood-group system; Breast neoplasms; Cervix neoplasms INTRODUCTION Cancer is one of the most health-threatening and complicated diseases around the world. It involves a greater population each year and affects the quality of life depending on different types, stages, and personal factors. Solid tumors such as breast cancer and cervix cancer are the prevalent malignancy in many countries and due to their progression rate can cause considerable death annually. Therefore, it is necessary to find out valuable factors that can give some information for accounting for risk, predicting progression, response to treatment, and outcome of cancer, and help us in better disease management. Breast cancer is the most common cancer in women and a common cause of cancer death1. Breast cancer is a heterogeneous disease on the molecular level and includes molecular features such as activation of human epidermal growth factor receptor 2 (HER2), estrogen receptor, progesterone receptor, and/or BRCA mutations. It is mostly curable in the early stages but can metastases to a distant organ in advanced form 1. Diffe

FAQs

What was the study’s objective regarding ABO and Rh blood groups?

To evaluate whether ABO and Rh blood groups are risk factors for breast cancer and cervix cancer.

How was the study conducted in terms of participants and data sources?

A retrospective study included patients diagnosed with breast cancer and cervix cancer with known ABO/Rh types, and compared distribution against data from a large-scale donor study in Khuzestan.

What were the key findings about the association between ABO/Rh and cancer risk?

The results showed no significant association between ABO and Rh and the risk of breast and cervix cancer, and no relationship between blood types and breast cancer clinicopathological features.

Sep 24, 2026

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