STNFR1 IS ASSOCIATED WITH DEPRESSIVE SYMPTOMS IN COMMUNITY-DWELLING OLDER ADULTS - A LOGISTIC REGRESSION ANALYSIS

Sep 29, 2026

Uploaded by jayni

This study investigates how inflammatory biomarkers relate to depressive symptoms in 91 community-dwelling older adults without dementia, using baseline data from a randomized clinical trial. Depression is measured by the Geriatric Depression Scale, with scores above 5 indicating depression. Plasma biomarkers (CRP, IL-6, TNF-α, and soluble TNF receptor-1, sTNFR1) are Z-score normalized, and logistic regression adjusts for age, sex, BMI, and mild cognitive impairment status. Results show sTNFR1 is significantly associated with depression, while CRP, IL-6, and TNF-α are not.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages1

Reading Time3 min

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Background and Rationale

Study Design and Participants

Depression and Biomarker Measures

Statistical Analysis

Key Findings

458 Innovation in Aging, 2025, Vol. 9, No. S2 Clinically, measuring sTNFR1 levels in routine visits may help in identifying older adults with risk for depression and informing early intervention strategies. Given its role in TNF-mediated inflammation, sTNFR1 warrants investigation as a potential target for interventions addressing late-life depression. Larger longitudinal studies should further elucidate the causal role of TNF signaling pathways in geriatric depression. Abstract citation ID: igaf122.1566 STNFR1 IS ASSOCIATED WITH DEPRESSIVE SYMPTOMS IN COMMUNITY-DWELLING OLDER ADULTS: A LOGISTIC REGRESSION ANALYSIS Russell Calderon1, Nada Lukkahatai2, Jing Huang2, Melissa Hladek2, and Junxin Li2, 1. Johns Hopkins School of Medicine, Baltimore, Maryland, United States, 2. Johns Hopkins University, Baltimore, Maryland, United States Inflammation has been implicated in the pathophysiology of depression, but specific inflammatory pathways may differentially contribute to depressive symptoms in older adults. This study examines the relationship between inflammatory biomarkers and depression in 91 community-dwelling older adults without dementia [Montreal Cognitive Assessment ≥17] using baseline data from a randomized clinical trial (NCT03959202) . Depression was assessed using the Geriatric Depression Scale, with scores >5 indicating depression. Plasma-derived inflammatory biomarkers, including C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and soluble TNF receptor-1 (sTNFR1), were Z-score normalized. A logistic regression model examined associations between biomarkers and depression, adjusting for age, sex, body mass index, and mild cognitive impairment (MCI) status. Participants were 70.2±6.2 years old, 80.2% females, 19.8% with MCI. Overall, 20.8% of participants (n = 19) were classified as having depression. In adjusted analyses, sTNFR1—a key mediator for TNF signaling—was significantly associated with depression (OR = 2.89, 95% CI [1.20, 5.60], p = 0.009), indicating that individuals with higher sTNFR1 levels had nearly three times the odds of depression. However, CRP, IL-6, and TNF-α were not significantly related to depression. These findings supportsTNFR1 as a potential inflammatory biomarker linked to late-life depression, independent of demographics and cognitive status.

FAQs

What inflammatory markers were analyzed in the study?

The study analyzed C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and soluble TNF receptor-1 (sTNFR1).

How was depression determined among participants?

Depression was assessed using the Geriatric Depression Scale, with scores greater than 5 indicating depression.

Which biomarker showed a significant relationship with depression?

In adjusted analyses, sTNFR1 was significantly associated with depression (OR = 2.89, p = 0.009), while CRP, IL-6, and TNF-α were not significant.

Sep 29, 2026

Uploaded by jayni