Spotlight on the Expanding Role of miR-647 in Human Cancers

Sep 24, 2026

MicroRNAs are small non-coding RNAs with epigenetically pivotal roles in gene regulation and other cellular processes, making them promising biomarkers for early cancer detection and management. This review summarizes evidence on the molecular mechanisms, target genes, and clinical significance of miR-647 across cancers. Studies report dysregulated miR-647 expression in multiple malignancies, where it can act as an oncomiR or tumor suppressor. miR-647 influences proliferation, migration, invasion, cancer progression, prognosis, and therapy response, including potential therapeutic targeting through antitumor drugs.

LanguageEnglish

CategoryHealthcare

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Abstract

Introduction

Materials and Methods

| Review Article | | --- | | | Spotlight on the Expanding Role of miR‑647 in Human Cancers Mohammadmahdi Jalili1, Setayesh Tavakoli1, Kamran Kargar2, Milad Rafat3, Fatemeh R. Rad3 1Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran, 2Department of Prosthodontics, Shahed Medical University, Tehran, Iran, 3Student Research Committee, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran Abstract MicroRNAs are a large group of small, non‑coding ssRNAs (miRNAs) that have an epigenetically pivotal role in gene expression and other biological processes in cells and can be regarded as capable biomarkers for the early detection and management of cancer. The aim of the present review article is to summarize the evidence for recognizing the molecular mechanism, target genes, and clinical significance of miR‑647 indifferent cancers. Multiple studies have demonstrated that aberrant expression of miR‑647 could be found in a variety of malignancies, such as bladder cancer, cervical cancer, colorectal cancer, gastric cancer, glioma, hepatocellular carcinoma, non‑small cell lung cancer, ovarian cancer, and prostate cancer have reported, notably, increase or decrease in expression of miR‑647 so that it can function as a tumorigenic (oncomiR) or tumor suppressor gene. MiR‑647 is effective in the proliferation, migration, and invasion of cancer cells by playing a function in cell cycle pathways. MiR‑647 can be a valuable potential biomarker for assessing the extent of cancer, prognosis, and response to therapy and shows great therapeutic efficacy in different solid tumors. Moreover, serum concentrations of miR‑647 are directly effective in decreasing overall survival and disease progression. So, an efficient therapeutic target can be the effect on miR‑647 expression by antitumor drugs. Keywords: Biomarker, cancer, microRNA, microRNA‑647, miR‑647 Address for correspondence: Dr. Fatemeh R. Rad, Student Research Committee, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran. E‑mail: [f. 2r.am86815@gmail.com](f. 2r.am86815@gmail.com) Submitted: 29‑Oct‑2022; Revised: 07‑Feb‑2023; Accepted: 08‑Feb‑2023; Published: 30‑Jun‑2023 IntroductIon Up to less than 2% of the human genome consists of 20,000 protein‑coding genes. It has been found that at least 70% of the genome sequences are transcribed into RNAs, and most of these transcripts have been determined as non‑coding RNAs (ncRNAs) . [1‑5] Ongoing advances in large‑scale genome sequencing revealed that long nRNAs (more than 200 nucleotides) and short ncRNAs (less than 20 nucleotides) are the major regulators ofthe human genome.[6‑8] MicroRNAs area large group of small, non‑coding ssRNAs that are endogenous and regulated across the mammalian genome. The human genome can encode around 1000 types of microRNAs. They are found in eukaryotes and are, on average, 22–24 nucleotides in length.[9] Their primary role is to post‑transcriptionally control gene expression. In this way, they interact with mRNAand silence the target gene. The majority of microRNA genes are generated in the intron regions of other genes and transcripted by RNA | Access this article online | | | --- | --- | | Quick Response Code:
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[www.advbiores.net](www.advbiores.net) | | | DOI:
10.4103/abr.abr_369_22 | polymerase II.[10] More intense studies are necessary to identify new biological events concerning carcinogenesis and new therapeutic targets such as microRNAs. The microRNAs have been aberrantly expressed in different cancerous tissues so that their expression can be increased, decreased, or remain stable.[11] In the human body, MiR‑647 is made of two homologous miRNAs on human chromosome 20q13.33, hsa‑miR‑647‑5p and hsa‑miR‑647‑3p.[12] TheRfold web server (Vienna package) was employed to predict and plot the secondary structure of miR‑647 with a minimum free‑energy of ‑42.70 kcal/moland dot‑bracket notation ([http://rna.tbi.u

FAQs

What is miR-647 and why is it relevant to cancer?

miR-647 is a microRNA whose dysregulated expression is linked to cancer development. The review emphasizes its roles in gene regulation and epigenetic control relevant to carcinogenesis.

How does miR-647 affect cancer cell behavior?

miR-647 contributes to cancer cell proliferation, migration, and invasion. It is also described as influencing pathways related to the cell cycle and apoptosis.

What clinical uses are proposed for miR-647?

The document presents miR-647 as a potential biomarker for assessing cancer extent, prognosis, and response to therapy. It also discusses circulating/serum levels in relation to survival and disease progression.

Sep 24, 2026

Uploaded by Taylor Morgan