SpinFlowSim - A blood flow simulation framework for histology-informed diffusion MRI microvasculature mapping in cancer

Sep 23, 2026

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SpinFlowSim presents a blood flow simulation framework designed for histology-informed diffusion MRI microvasculature mapping in cancer. The work is published in Med Image Analysis (2025), with an open-access author manuscript available in PMC. It includes details on affiliations across research and clinical institutes and provides declarations regarding competing financial interests and funding support. The manuscript also includes supplementary data availability and a CRediT authorship contribution statement describing author roles.

LanguageEnglish

CategoryResearch & Report

FormatPDF

Pages42

Reading Time1 h 46 min

AccessFree to download

Published details

Open access and licensing

Supplementary data

Competing interests

CRediT authorship contribution statement

Author Manuscr ipt Author Manuscr ipt Author Manuscr ipt Author Manuscript | | HHS Public Access
Author manuscript
Med Image Anal. Author manuscript; available in PMC 2025 June 01. | | --- | --- | Published in final edited form as: Med Image Anal. 2025 May ; 102: [103531. doi:10.1016/j.media.2025.103531](103531. doi:10.1016/j.media.2025.103531) . SpinFlowSim: A blood flow simulation framework for histologyinformed diffusion MRI microvasculature mapping in cancer Anna Kira Voronovaa,b, Athanasios Grigorioua,b, Kinga Bernatowicza, Sara Simonettia, Garazi Sernaa, Núria Rosonc,d, Manuel Escobarc,d, Maria Vieitoe, Paolo Nuciforoa, Rodrigo Toledoa, Elena Garraldae, Els Fieremansf, Dmitry S. Novikovf, Marco Palombog,h, Raquel Perez-Lopeza,*,1 , Francesco Grussua,*,1 aVall d’Hebron Institute of Oncology (VHIO), Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain b Department of Biomedicine, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain c Institut de Diagnòstic per la Imatge (IDI), Barcelona, Spain This is an open access article under the CC BY-NC license ([http://creativecommons.org/licenses/by-nc/4.0/](http://creativecommons.org/licenses/by-nc/4.0/)). *Correspondence to: VHIO, Carrer de Saturnino Calleja 11-13, 08035 Barcelona, Spain., [rperez@vhio.net](rperez@vhio.net) (R. Perez-Lopez), f1grEussuqualvhiontrib.neutito(Fn(.jGruointsssn) .ior authors) . Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: RPL reports financial support was provided by Agencia Estatal de Investigación. RPL reports financial support was provided by Cellex Foundation. RPL reports financial support was provided by CERCA Programme from the Generalitat de Catalunya. RPL reports financial support was provided by AstraZeneca. RPL reports financial support was provided by European Regional Development Fund. EG reports financial support was provided by Banco Bilbao Vizcaya Argentaria Foundation Foundation. RPL reports financial support was provided by LaCaixa Foundation. FG reports financial support was provided by LaCaixa Foundation. RPL reports financial support was provided by Prostate Cancer Foundation. RPL reports financial support was provided by CRIS Cancer Foundation. RPL reports was provided by Fero Foundation. RPL reports financial support was provided by Carlos III Health Institute. RPL reports financial support was provided by Spanish Association Against Cancer Scientific Foundation. RPL reports financial support was provided by Government of Catalonia Agency for Administration of University and Research Grants. KB reports financial support was provided by Government of Catalonia Agency for Administration of University and Research Grants. MP reports financial support was provided by UK Research and Innovation. AG reports financial support was provided by Agencia Estatal de Investigación. This study has received support by AstraZeneca. K.B. was a researcher at VHIO (Barcelona, Spain), and is now an employee of AstraZeneca (Barcelona, Spain). AstraZeneca was not involved in the acquisition and analysis of the data, interpretation of the results, or the decision to submit this article for publication in its current form. All other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Appendix A. Supplementary data Supplementary material related to this article can be found online at [https://doi.org/10.1016/j.media.2025.103531](https://doi.org/10.1016/j.media.2025.103531) . CRediT authorship contribution statement Anna Kira Voronova: Writing – review & editing, Writing – original draft, Visualization, Validation, Software, Resources, Project administration, Methodology, Investigation, Formal analysis, Data curation, Conceptualization. Athanasios Gri

FAQs

What is SpinFlowSim intended to do?

SpinFlowSim is a blood flow simulation framework aimed at histology-informed diffusion MRI microvasculature mapping in cancer.

Where is the manuscript published and what is the publication status?

The work is published in Med Image Analysis in 2025 and is available as an open-access author manuscript in PMC.

Does the manuscript include information about conflicts of interest and funding?

Yes. It contains a declaration of competing interests and extensive statements about financial support from multiple organizations and programs.

Sep 23, 2026

Upload by Jake