Signet-ring cell carcinoma of the transverse colon in a 10-year-old girl - A case report

Sep 22, 2026

Signet-ring cell carcinoma (SRCC) is a rare colorectal cancer subtype, and primary colonic SRCC in pediatric patients remains uncommon with limited published cases. This case report presents the diagnosis of primary SRCC in the transverse colon of a 10-year-old girl. The patient was investigated for abdominal pain and vomiting, underwent surgical resection and lymph node dissection, and received postoperative standard chemotherapy. Pathology confirmed SRCC with nerve and full-wall infiltration, vascular and lymphatic tumor thrombi, omental nodules, metastases in 18/26 mesenteric nodes, microsatellite stability, and no KRAS/NRAS/BRAF/PIK3CA mutations. After 12 months of follow-up, no tumor progression was observed.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages8

Reading Time20 min

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Case Summary

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| W | J | G | O | World Journal of
Gastrointestinal Oncology | | --- | --- | --- | --- | --- | Submit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Gastrointest Oncol 2024 December 15; 16(12): 4746-4752 DOI: 10.4251/wjgo.v16.i12.4746 ISSN 1948-5204 (online) CASE REPORT Signet-ring cell carcinoma of the transverse colon in a 10-year-old girl: A case report Ling Lv, Yuan-Hua Song, Yan Gao, Shuang-Qiong Pu, Zhi-Xiang A, Hong-Fang Wu, Jun Zhou, Yu-Cheng Xie Specialty type: Gastroenterology and hepatology Provenance and peer review: Unsolicited article; Externally peer reviewed. Peer-review model: Single blind Peer-review report’s classification Scientific Quality: Grade C, Grade C, Grade C, Grade D, Grade D Novelty: Grade B, Grade B, Grade B, Grade C, Grade C Creativity or Innovation: Grade B, Grade C, Grade C, Grade C, Grade C Scientific Significance: Grade B, Grade B, Grade B, Grade C, Grade C P-Reviewer: Kanda T; Nakamura T; Xu DH Received: August 5, 2024 Revised: September 29, 2024 Accepted: October 18, 2024 Published online: December 15, 2024 Processing time: 98 Days and 17.5 Hours Ling Lv, Yan Gao, Shuang-Qiong Pu, Zhi-Xiang A, Hong-Fang Wu, Jun Zhou, Yu-Cheng Xie, Department of Pathology, Kunming Children’s Hospital, Kunming 650028, Yunnan Province, China Yuan-Hua Song, Department of Oncology, Kunming Children’s Hospital, Kunming 650028, Yunnan Province, China Co-first authors: Ling Lv and Yuan-Hua Song. Co-corresponding authors: Jun Zhou and Yu-Cheng Xie. Corresponding author: Yu-Cheng Xie, Chief Physician, Department of Pathology, Kunming Children’s Hospital, No. 288 Qianxing Road, Kunming 650028, Yunnan Province, China. [7151290@qq.com](7151290@qq.com) Abstract BACKGROUND Signet-ring cell carcinoma (SRCC) is a rare subtype of colorectal cancer. The incidence of primary colonic SRCC is relatively rare in pediatric patients, with a limited number of reported cases currently available. The prognosis for this specific tumor type is unfavorable, and the preoperative diagnosis presents challenges, potentially leading to misdiagnosis. This case report describes the diagnosis of primary SRCC in the colon of a 10-year-old girl. CASE SUMMARY The patient was admitted to the hospital due to abdominal pain and vomiting. A computed tomography scan revealed an irregular mass with soft tissue density in her transverse colon, showing uneven density and multiple calcifications. The patient underwent surgical resection of the affected bowel and lymph node dissection, which was confirmed by pathological examination to be SRCC infiltrating both nerves and the entire intestinal wall. Additionally, tumor thrombus formation was observed in blood vessels and lymphatic vessels, multiple cancerous nodules were found in the omentum, and metastasis to 18 of 26 mesenteric lymph nodes examined. Immunohistochemistry for mismatch repair gene protein demonstrated microsatellite stability. No mutations in KRAS, NRAS, BRAF, or PIK3CA genes were detected through molecular pathology analysis. After surgery, she received standard chemotherapy for 8 cycles without tumor progression or other abnormalities during a 12-month follow-up period. WJGO [https://www.wjgnet.com](https://www.wjgnet.com) 4746 December 15, 2024 Volume 16 Issue 12 Lv L et al. A pediatric SRCC CONCLUSION Primary colonic SRCC is a rare malignant tumor with atypical clinical symptoms, and timely identification and intervention are crucial for improving the prognosis. Key Words: Signet ring cell cancer; Colon; Pediatric; Pathological presentation; Case report ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. Core Tip: We present a case of primary signet-ring cell carcinoma of the colon in a 10-year-old girl. Pediatric signet-ring cell carcinoma is an exceptionally rare condition with atypical clinical symptoms, making early diagnosis challen

FAQs

What condition does the case report describe?

The report describes primary signet-ring cell carcinoma (SRCC) located in the transverse colon of a 10-year-old girl.

How was the diagnosis confirmed?

Computed tomography showed an irregular transverse colon mass with calcifications. Pathological examination after surgical resection confirmed SRCC with nerve and full intestinal wall infiltration, along with metastatic involvement.

What treatments were given and what was the outcome?

The patient underwent surgical resection with lymph node dissection, followed by standard chemotherapy for eight cycles. During a 12-month follow-up period, there was no tumor progression or other abnormalities.

Sep 22, 2026

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