SGK3 overexpression correlates with a poor prognosis in endoscopically resected superficial esophageal squamous cell neoplasia - A long-term study

Sep 24, 2026

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Retrospective long-term analysis evaluated serum and glucocorticoid-induced protein kinase 3 (SGK3) expression in superficial esophageal squamous cell neoplasia (ESCN), where expression status and clinical value were previously unclear. Ninety-two endoscopically resected ESCN patients with follow-up exceeding eight years were included, with immunohistochemistry used to assess SGK3. SGK3 overexpression occurred in 59.8% and significantly correlated with death, with worse overall and disease-free survival. Cox regression identified SGK3 overexpression as an independent predictor of poor prognosis, suggesting SGK3 as a new prognostic marker.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages11

Reading Time28 min

AccessFree to download

Abstract

Background

Aim

Methods

Results

Conclusion

Introduction

Esophageal cancer and superficial ESCN context

SGK family and SGK3 rationale

| W | J | G | World Journal of
Gastroenterology | | --- | --- | --- | --- | Submit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Gastroenterol 2023 June 21; 29(23): 3658-3667 DOI: 10.3748/wjg.v29.i23.3658 ISSN 1007-9327 (print) ISSN 2219-2840 (online) ORIGINAL ARTICLE Retrospective Study SGK3 overexpression correlates with a poor prognosis inendoscopically resected superficial esophageal squamous cell neoplasia: A long-term study Ning Xu, Long-Song Li, Hui Li, Li-Hua Zhang, Nan Zhang, Peng-Ju Wang, Ya-Xuan Cheng, Jing-Yuan Xiang, En-Qiang Linghu, Ning-Li Chai Specialty type: Gastroenterology and hepatology Provenance and peer review: Unsolicited article; Externally peer reviewed. Peer-review model: Single blind Peer-review report’s scientific quality classification Grade A (Excellent): 0 Grade B (Very good): B, B Grade C (Good): 0 Grade D (Fair): 0 Grade E (Poor): 0 P-Reviewer: Hwang GS, South Korea; Tsai NM, Taiwan Received: February 24, 2023 Peer-review started: February 24, 2023 First decision: March 14, 2023 Revised: March 20, 2023 Accepted: May 23, 2023 Article in press: May 23, 2023 Published online: June 21, 2023 Ning Xu, Long-Song Li, Nan Zhang, Peng-Ju Wang, Ya-Xuan Cheng, Jing-Yuan Xiang, En-Qiang Linghu, Ning-Li Chai, Senior Department of Gastroenterology, The First Medical Center of PLA General Hospital, Beijing 100853, China Hui Li, Department of Gastroenterology, Air Force Medical Center, Beijing 100142, China Li-Hua Zhang, Department of Pathology, The Fourth Medical Center of PLA General Hospital, Beijing 100142, China Corresponding author: Ning-Li Chai, MD, PhD, Chief Doctor, Senior Department of Gastroenterology, The First Medical Center of PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, [China.](China. chainingli@vip.163.com)[ chainingli@vip.163.com](China. chainingli@vip.163.com) Abstract BACKGROUND The expression status of serum and glucocorticoid-induced protein kinase 3 (SGK3) in superficial esophageal squamous cell neoplasia (ESCN) remains unknown. AIM To evaluate the SGK3 overexpression rate in ESCN and its influence on the prognosis and outcomes of patients with endoscopic resection. METHODS A total of 92 patients who had undergone endoscopic resection for ESCN with more than 8 years of follow-up were enrolled. Immunohistochemistry was used to evaluate SGK3 expression. RESULTS SGK3 was overexpressed in 55 (59.8%) patients with ESCN. SGK3 overexpression showed a significant correlation with death (P = 0.031) . Overall survival and disease-free survival rates were higher in the normal SGK3 expression group than in the SGK3 overexpression group (P = 0.013 and P = 0.004, respectively) . Cox regression analysis models demonstrated that SGK3 overexpression was an independent predictor of poor prognosis in ESCN patients (hazard ratio 4.729; WJG [https://www.wjgnet.com](https://www.wjgnet.com) 3658 June 21, 2023 Volume 29 Issue 23 Xu N et al. SGK3 overexpression correlates with poor prognosis 95% confidence interval: 1.042-21.458) . CONCLUSION SGK3 overexpression was detected in the majority of patients with endoscopically resected ESCNand was significantly associated with shortened survival. Thus, it might be a new prognostic factor for ESCN. Key Words: Superficial esophageal squamous cell neoplasia; Serum and glucocorticoid-induced protein kinase; Endoscopic submucosal dissection; Immunohistochemistry; Overall survival ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. Core Tip: This study demonstrated that the expression status of serum and glucocorticoid-induced protein kinase 3 (SGK3) was high in the majority of patients with superficial esophageal squamous cell neoplasia (ESCN) and that high expression of SGK3 predicts a poor prognosis. These findings provide a new prognostic factor for ESCN. Citation: Xu N

FAQs

What was the main purpose of the study on SGK3 in ESCN?

To determine the SGK3 overexpression rate in superficial esophageal squamous cell neoplasia and assess its impact on patient prognosis and outcomes after endoscopic resection.

How were SGK3 expression levels measured in the patients?

Immunohistochemistry was used to evaluate SGK3 expression in enrolled ESCN cases.

What did the results show about SGK3 overexpression and prognosis?

SGK3 overexpression was found in 59.8% of patients and was significantly associated with death, with lower overall survival and disease-free survival in the overexpression group. Cox regression indicated it was an independent predictor of poor prognosis.

Sep 24, 2026

Uploaded by Jake