Sex, education and race/ethnicity have distinct effects on amyloid and tau-PET status

Sep 30, 2026

Uploaded by Riley

Alzheimer Center Amsterdam and an international multi-institution team present a neuroimaging biomarker study evaluating how sex, education, and race/ethnicity relate to amyloid and tau PET status. The article is published as an open-access BIOMARKERS podium presentation and is identified by DOI 10.1002/alz70856_105387, with publication details in Alzheimer’s & Dementia. Institutional affiliations span Europe, the United States, Australia, and China, supporting an analysis of demographic influences on PET-defined pathology status.

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DOI: 10. 1002/alz70856_105387 BIOMARKERS PODIUM PRESENTATION NEUROIMAGING Sex, education and race/ethnicity have distinct effects on amyloid and tau-PET status Colin Groot1 Emma M. Coomans2 Christopher C. Rowe3, 4 Vincent Dore5, 6 Azadeh Feizpour7 Elsmarieke van de Giessen8 Wiesje M. van der Flier9 Yolande A. L. Pijnenburg 10 Pieter Jelle Visser 1 Anouk den Braber 1 Michael J. Pontecorvo 11 Samantha C. Burnham 11 IanA. Kennedy 11 Ming Lu 11 William J. Jagust 12 Suzanne L. Baker 12 Theresa M. Harrison 13 Juan Domingo Gispert 14 Mahnaz Shekari 15 Carolina Minguillón 15 Ruben Smith 16 Niklas Mattsson-Carlgren 16 Sebastian Palmqvist 17 Olof Strandberg 17 Erik Stomrud 17 Adam Brickman 18 José A Luchsinger 19 Jennifer J. Manly 19, 20 Patrick J. Lao 19 William Charles Kreisl 19 Maura Malpetti21 John T O’Brien22 James B Rowe23 Elena Jäger24 Gérard N Bischof24 Alexander Drzezga24 Fang Xie25 Xiaoxie Mao26 Yihui Guan27 Valentina Garibotto28 Giovanni B Frisoni29 Débora E. Peretti30 Michael Schöll31 Ingmar Skoog32 Silke Kern31 ReisaA. Sperling33 Keith A. Johnson34 Shannon Risacher35 Andrew J. Saykin36 Maria C. Carrillo37 Brad Dickerson38 Liana G. Apostolova39 Gil D. Rabinovici40 Henryk Barthel41 Michael Rullmann41 Konstantin Messerschmidt42 Rik Vandenberghe43 Koen Van Laere44 Laure Spruyt45 Ronald Petersen46 Clifford R. Jack Jr.46 Nicolai Franzmeier47 Matthias Brendel48 Johannes Gnörich49 Tammie Benzinger50 Julien Lagarde51 Marie Sarazin52 Michel Bottlaender51 Sylvia Villeneuve53 Judes Poirier54 Sang Won Seo55 Yuna Gu56 Jun Pyo Kim55 Beth Mormino57 Christina B. Young57 Hillary Vossler58 Pedro Rosa-Neto59 Joseph Therriault60 Nesrine Rahmouni61 William Coath62 David M Cash62 Jonathan M Schott63 Bernard J Hanseeuw64 Yasmine Salman64 Vincent Malotaux64 Willemijn J. Jansen65 Renaud La Joie66 Howard J. Rosen67 Sterling C Johnson68 Bradley T Christian69 Tobey J. Betthauser70 Susan M. Landau71 Sid E. O’Bryant72 Oskar Hansson 17 Rik Ossenkoppele73, 74 ADNI, ADNI-DOD, A-Study, MCSA, Prevent-AD This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2025 The Alzheimer’s Association. Alzheimer’s & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer’s Association. Alzheimer’s Dement. 2025;21(Suppl. 2):e105387. wi[leyonlinelibrary.com/journal/alz](leyonlinelibrary.com/journal/alz) 1of5 [https://doi.org/10.1002/alz70856_105387](https://doi.org/10.1002/alz70856_105387) 2of5 BIOMARKERS 1Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, Netherlands 2 Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands 3 University of Melbourne, Melbourne, VIC, Australia 4 Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Vic, 3084, Australia, Heidelberg, VIC, Australia 5 CSIRO, Brisbane, QLD, Australia 6 Department of Molecular Imaging, Austin Health, Melbourne, VIC, Australia 7 Department of Molecular Imaging & Therapy, Austin Health, Melbourne, VIC, Australia 8Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, Netherlands 9Alzheimer Center Amsterdam, Neurology, Amsterdam UMC Location VUmc, Vrije Universiteit Amsterdam, Amsterdam, Netherlands 10Alzheimer Center Amsterdam, Department of Neurology, Amsterdam UMC, location VUmc, Amsterdam, Netherlands 11 Eli Lilly and Company, Indianapolis, IN, USA 12 Lawrence Berkeley National Laboratory, Berkeley, CA, USA 13 University of California, Berkeley, Berkeley, CA, USA 14 Barcelona?eta Brain Research Center (BBRC), Barcelona, Spain 15 Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain 16 Clinical Memory Research Unit, Lund University, Malmö, Skåne, Sweden 17 Clinical Memory Re

FAQs

What biological markers does the study focus on?

The study focuses on amyloid and tau biomarkers measured by PET imaging, summarized by “amyloid and tau-PET status.”

Which demographic factors are examined for effects on PET status?

Sex, education, and race/ethnicity are examined as distinct factors affecting amyloid and tau-PET status.

Where is the research presented and published?

It is listed as a BIOMARKERS podium presentation and published in Alzheimer’s & Dementia under DOI: 10.1002/alz70856_105387.

Sep 30, 2026

Uploaded by Riley