Screening and surveillance of esophageal cancer by magnifying endoscopy with narrow band imaging improves the survival of hypopharyngeal cancer patients

Sep 21, 2026

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Retrospective analysis evaluated whether esophageal cancer screening and surveillance using magnifying endoscopy with narrow band imaging (ME-NBI) improves outcomes for hypopharyngeal cancer patients. Patients diagnosed between 2008 and 2021 in a tertiary hospital were stratified into three ME-NBI timing and surveillance patterns: none/late, within 6 months only, and within 6 months with regular surveillance. Among 261 patients, 26% developed second primary neoplasms, and multivariate Cox regression showed that advanced stages and timely regular ME-NBI were independent determinants of overall survival.

LanguageEnglish

CategoryResearch & Report

FormatPDF

Pages10

Reading Time25 min

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Introduction

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TYPE Original Research PUBLISHED 23 January 2024 DOI 10.3389/fonc.2023.1221616 OPEN ACCESS EDITED BY Jason Chia-Hsun Hsieh, New Taipei Municipal TuCheng Hospital, Taiwan REVIEWED BY Tsung Lun Lee, Taipei Veterans General Hospital, Taiwan Hao-Tsai Cheng, New Taipei Municipal TuCheng Hospital, Taiwan *CORRESPONDENCE Li-Jen Liao [liaolj@ntu.edu.tw](liaolj@ntu.edu.tw) †These authors have contributed equally to this work RECEIVED 12 May 2023 ACCEPTED 31 December 2023 PUBLISHED 23 January 2024 CITATION Chung C-S, Wu C-Y, Lin Y-H, Lo W-C, Cheng P-C, Hsu W-L and Liao L-J (2024) Screening and surveillance of esophageal cancer by magnifying endoscopy with narrow band imaging improves the survival of hypopharyngeal cancer patients. Front. Oncol. 13:1221616 . doi: 10.3389/fonc.2023.1221616 COPYRIGHT © 2024 Chung, Wu, Lin, Lo, Cheng, Hsu and Liao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Screening and surveillance of esophageal cancer by magnifying endoscopy with narrow band imaging improves the survival of hypopharyngeal cancer patients Chen-Shuan Chung 1,2†, Chia-Yun Wu 3,4†, Yu-Hsuan Lin 3,5, Wu-Chia Lo 3,6,7, Ping-Chia Cheng 3,6, Wan-Lun Hsu 5 and Li-Jen Liao 3,6,8* 1 Division of Gastroenterology and Hepatology, Far Eastern Memorial Hospital, New Taipei, Taiwan, 2College of Medicine, Fu Jen Catholic University, New Taipei, Taiwan, 3 Department of Oncology and Hematology, Far Eastern Memorial Hospital, New Taipei, Taiwan, 4 Head and Neck Cancer Surveillance & Research Group, Far Eastern Memorial Hospital, New Taipei, Taiwan, 5 Master’s Program of Big Data Analysis in Biomedicine, Fu Jen Catholic University, New Taipei, Taiwan, 6 Department of Otolaryngology, Far Eastern Memorial Hospital, New Taipei, Taiwan, 7Graduate Institute of Medicine, Yuan Ze University, Taoyuan, Taiwan, 8 Department of Electrical Engineering, Yuan Ze University, Taoyuan, Taiwan Introduction: Patients with head and neck cancer may develop a second primary neoplasm (SPN) of the esophagus due to ﬁeld cancerization. This study investigated the impacts of esophageal cancer screening using magnifying endoscopy with narrow-band imaging (ME-NBI) on the outcomes of hypopharyngeal cancer patients. Methods: Patients with hypopharyngeal cancer diagnosed from 2008 to 2021 in a tertiary hospital were reviewed retrospectively. Screening and surveillance using ME-NBI examination of the esophagus were divided into three patterns: (1) ME-NBI never performed or more than 6 months after diagnosis of index primary hypopharyngeal cancer,(2) ME-NBI within 6 months only, and (3) MENBI within 6 months and regular surveillance. Results: A total of 261 were reviewed and 21 (8%) patients were in stage I, 20 (8%) in stage II, 27 (10%) in stage III, 116 (44%) in stage IVA, 65 (25%) in stage IVB, and 12 (5%) in stage IVC. Sixty-seven (26%) patients had SPN (50 esophagus, 10 oral cavity, 3 oropharynx, 2 nasopharynx, 1 larynx and 1 lung) . Among esophageal SPN, 35 (70%) and 15 (30%) patients developed synchronous and metachronous neoplasia, respectively. In multivariate Cox regression analysis, advanced stages III and IV (compared with stages I and II, HR: 1.86, 1.18-2.95, p=0.008), ME-NBI examination of the esophagus received within 6 months and regular surveillance (HR: 0.53, 0.36-0.78, p=0.001) were independent factors affecting the overall survival of patients with hypopharyngeal cancer . Frontiers in Oncology 01 [frontiersin.org](frontiersin.org) Discussion: Our ﬁndings demonstrated that screening and surveillance of esophageal SPN

FAQs

What question does the study address about hypopharyngeal cancer patients?

It assesses whether esophageal cancer screening and surveillance using ME-NBI affects clinical outcomes for patients with hypopharyngeal cancer.

How were patients grouped for ME-NBI screening and surveillance?

They were divided into three patterns: ME-NBI never performed or performed more than 6 months after diagnosis, ME-NBI performed within 6 months only, and ME-NBI performed within 6 months with regular surveillance.

What did multivariate Cox regression identify as independent factors for overall survival?

Advanced stages III–IV increased risk compared with stages I–II, while ME-NBI performed within 6 months with regular surveillance was associated with improved overall survival.

Sep 21, 2026

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