SCORE2 and SCORE2-OP Assessment in the Predicting of Cardiovascular Diseases and AF Recurrence in Hypertensive AF Patients Who Underwent Catheter Ablation

Q: What was the main aim of assessing SCORE2 and SCORE2-OP in this study?

To determine how SCORE2 and SCORE2-OP risk scores affect AF recurrence and CVD development after catheter ablation in hypertensive AF patients.

Q: How were patients grouped for analysis?

Patients were categorized into three groups (I-II-III) based on their CVD risk thresholds in SCORE2 and SCORE2-OP: <5%, 5% to <10%, and ≥10%.

Q: What factors independently predicted CVD development?

The presence of CVD risk ≥10%, CHA2DS2-VA, and uric acid independently predicted CVD development in logistic regression.

Sep 30, 2026

Uploaded by Ben

Hypertension (HT) is a modifiable risk factor for cardiovascular disease (CVD) in atrial fibrillation (AF), yet evidence is lacking on how SCORE2 and SCORE2-OP risk scores relate to outcomes in AF. This retrospective cohort study assessed 266 patients with paroxysmal AF undergoing catheter ablation and grouped them by SCORE2/SCORE2-OP CVD risk strata. The study evaluated adverse CVD as the primary endpoint and AF recurrence as the secondary endpoint, including logistic regression predictors for both outcomes.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages14

Reading Time35 min

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Abstract

Background/aims

Methods

Results

Conclusions

1. Introduction

Article SCORE2 and SCORE2-OP Assessment in the Predicting of Cardiovascular Diseases and AF Recurrence in Hypertensive AF Patients Who Underwent Catheter Ablation Gülhan Yüksel 1, *, Mustafa Lütfullah Ardıç 1, Hilmi Erdem Sumbul 2 and Mevlut Koc 1 Academic Editor: Teruhiko Imamura Received: 23 November 2025 Revised: 11 December 2025 Accepted: 26 December 2025 Published: 30 December 2025 Copyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. 1 Department of Cardiology, University of Health Sciences, Adana Health Practice and Research Center, Adana 01230, Turkey; [drmustafaardic@gmail.com](drmustafaardic@gmail.com) (M.L.A.); [mevlutkoc78@yahoo.com](mevlutkoc78@yahoo.com) (M.K.) 2 Department of Internal Medicine, University of Health Sciences, Adana Health Practice and Research Center, Adana 01230, Turkey; [erdemsumbul@gmail.com](erdemsumbul@gmail.com) * Correspondence: [gulhankalkan@yahoo.com.tr](gulhankalkan@yahoo.com.tr); Tel.: +90-505-272-4294 Abstract Background/aims: Hypertension (HT) is a modifiable risk factor for the development of cardiovascular disease (CVD) in patients with atrial fibrillation (AF) . There are no data on the use of the SCORE2 and SCORE2-OP risk scores used in patients with AF. In our study, we aimed to determine the effect of SCORE2 and SCORE2-OP risk scores on AF recurrence and CVD development after catheter ablation (CA) in AF patients with HT. Methods: This retrospective cohort study included 266 patients (144 men, 122 women, 57.1 ± 11 years) who underwent CA with a diagnosis of paroxysmal AF. Patients were grouped as <5%-5% to <10%-≥10%(Group I-II-III, respectively) according to CVD risk in SCORE2 and SCORE2-OP. The primary endpoint was adverse CVD. The secondary endpoint was AF recurrence. Results: The frequency of CVD and AF recurrence in groups I-II-III was 0(0%)-8(8%)-14(15%) and 9(13%)-17(16%)-23(25%), respectively (p = 0.001 and p = 0.035) . Age, systolic blood pressure, presence of CVD risk ≥ 10%, CHA2DS2-VA, BUN, and uric acid were found to be higher in those with CVD. In logistic regression analysis, the presence of CVD risk ≥ 10%, CHA2DS2-VA and uric acid were found to independently predict the development of CVD (OR = 3.960, 95%CI-1.098–8.508, p = 0.019, OR = 3.257, 95%CI-1.067–7.318, p = 0.015 and OR = 1.967, 95%CI-1.359–2.873, p = 0.001) . Triglycerides, CVD risk of ≥10%, and left atrial end-diastolic diameter (LAd) were found to be higher in those with AF recurrence. In regression analysis, the presence of CVD risk ≥ 10% and LAd were found to independently determine the development of AF recurrence (OR = 2.448, 95%CI-0.993–1.023, p = 0.005, OR = 1.217, 95%CI-1.124–1.319) . Conclusions: SCORE2 and SCORE2-OP algorithms performed before the procedure in isolated HT patients undergoing ablation for paroxysmal AF can be used to predict AF recurrence and CVD development. The SCORE2 and SCORE2-OP algorithms have been evaluated exclusively in patients with isolated hypertension; therefore, further studies are needed to determine their applicability in the broader atrial fibrillation population. Keywords: atrial fibrillation; hypertension; catheter ablation; recurrence; SCORE2 and SCORE2-OP 1. Introduction Hypertension (HT) is the most important modifiable risk factor for adverse cardiovascular (CV) outcomes [1] . Uncontrolled HT is associated with hypertension-mediated organ damage (HMOD) [1] . Cardiac involvement of HMOD may persist subclinically for long periods of time: (i) atrial fibrillation (AF),(ii) left atrial (LA) and left ventricular (LV) dilatation,(iii) impaired LV systolic and diastolic function and heart failure (HF),(iv) LV hypertrophy,(v) obstructive and non-obstructive coronary artery disease (CAD),(vi) myocardial infarction, and (vii) increased cardiac biomarkers hs-cTn and NT-proBNP [1–3] .

FAQs

What was the main aim of assessing SCORE2 and SCORE2-OP in this study?

To determine how SCORE2 and SCORE2-OP risk scores affect AF recurrence and CVD development after catheter ablation in hypertensive AF patients.

How were patients grouped for analysis?

Patients were categorized into three groups (I-II-III) based on their CVD risk thresholds in SCORE2 and SCORE2-OP: <5%, 5% to <10%, and ≥10%.

What factors independently predicted CVD development?

The presence of CVD risk ≥10%, CHA2DS2-VA, and uric acid independently predicted CVD development in logistic regression.

Sep 30, 2026

Uploaded by Ben