Same Organ, Two Cancers - Complete Analysis of Renal Cell Carcinomas and Upper Tract Urothelial Carcinomas

Sep 21, 2026

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Renal cell carcinomas and upper tract urothelial carcinomas are kidney-origin malignancies with rising incidence and mortality. This retrospective study comprehensively characterizes these cancers by clinical, paraclinical, and histological features to estimate aggressiveness and death risk. Among 188 suspected patients, urothelial carcinoma cases showed higher mortality and older age, with anemia, acute kidney injury, hematuria, and perineural invasion as key predictors. In renal cell carcinoma, tumor size related to necrosis and sarcomatoid areas, while death indicators included older age, renal capsule involvement, full kidney lesions, lymphovascular invasion, acute kidney injury, and anemia. Histopathology differentiates tumors despite similar clinical patterns.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages25

Reading Time1 h 3 min

AccessFree to download

Introduction

Materials and Methods

Results

Risk factors and mortality predictors

Histological and clinical correlations

Discussion

Conclusions

medicina Article Same Organ, Two Cancers: Complete Analysis of Renal Cell Carcinomas and Upper Tract Urothelial Carcinomas Sorin Vamesu 1, Oana Andreea Ursica 1,2, Serban Eduard Milea 1, Mariana Deacu 1,2, Mariana Aschie 1,2,3,4,5, Anca Florentina Mitroi 5,6, Felix Voinea 2,7, Mihaela Butcaru Pundiche 2,8, Cristian Ionut Orasanu 1,2,5, * and Raluca Ioana Voda 1,2,5 Citation: Vamesu, S.; Ursica, O.A.; Milea, S.E.; Deacu, M.; Aschie, M.; Mitroi, A.F.; Voinea, F.; Pundiche, M.B.; Orasanu, C.I.; Voda, R.I. Same Organ, Two Cancers: Complete Analysis of Renal Cell Carcinomasand Upper Tract Urothelial Carcinomas. Medicina 2024, 60, 1126 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)medicina60071126 Academic Editor: Davide Bolignano Received: 7 June 2024 Revised: 6 July 2024 Accepted: 10 July 2024 Published: 12 July 2024 Copyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) . 1 Clinical Service of Pathology, Departments of Pathology,“Sf. Apostol Andrei” Emergency County Hospital, 900591 Constanta, Romania 2 Faculty of Medicine,“Ovidius” University of Constanta, 900470 Constanta, Romania 3 Department of Anatomy, Academy of Medical Sciences of Romania, 030171 Bucharest, Romania 4 Department of Medical Sciences, The Romanian Academy of Scientists, 030167 Bucharest, Romania 5 Center for Research and Development of the Morphological and Genetic Studies of Malignant Pathology (CEDMOG),“Ovidius” University of Constanta, 900591 Constanta, Romania 6 Clinical Service of Pathology, Departments of Genetics,“Sf. Apostol Andrei” Emergency County Hospital, 900591 Constanta, Romania 7 Urology Clinical Department,“Sf. Apostol Andrei” Emergency County Hospital, 900591 Constanta, Romania 8 Clinical Department of General Surgery,“Sf. Apostol Andrei” Emergency County Hospital, 900591 Constanta, Romania * Correspondence: [critian.ionut@gmail.com](critian.ionut@gmail.com); Tel.: +40-72-281-4037 Abstract: Background and Objectives: Renal cell carcinomas and upper tract urothelial carcinomas are types of malignancies that originate in the kidneys. Each of these examples shows an increasing trend in the frequency and the mortality rate. This study aims to comprehensively define carcinomas by analyzing clinical, paraclinical, and histological aspects to predict aggressiveness and mortality. Materials and Methods: We conducted a retrospective investigation on a group of patients suspected of kidney cancers. Results: We identified 188 cases. We observed a higher mortality rate and older age in individuals with urothelial carcinomas. Anemia, acute kidney injury, hematuria, and perineural invasion were the main risk factors that predicted their mortality. Tumor size in renal cell carcinomas correlates with the presence of necrosis and sarcomatoid areas. Factors that indicate a higher rate of death are older age, exceeding the renal capsule, a lesion that includes the entire kidney, lymphovascular invasion, acute kidney injury, and anemia. Conclusions: Even if they originate at the renal level, and the clinical–paraclinical picture is similar, the histopathological characteristics make the difference. In addition, to these are added the previously mentioned common parameters that can represent important prognostic factors. In conclusion, the characteristics commonly identified in one type of cancer may act as risk factors for the other tumor. The detected data include threshold values and risk factors, making a significant contribution to the existing literature. Keywords: renal cell carcinoma; upper tract urothelial carcinoma; perineural invasion; risk factor; hematuria 1. Introduction

FAQs

What is the purpose of the study on renal cell carcinomas and upper tract urothelial carcinomas?

To comprehensively define these carcinomas using clinical, paraclinical, and histological aspects, aiming to predict aggressiveness and mortality.

Which factors were identified as main risk predictors of mortality in upper tract urothelial carcinomas?

Anemia, acute kidney injury, hematuria, and perineural invasion were reported as the main risk factors.

How do histopathological characteristics contribute compared with similar clinical–paraclinical pictures?

Even when originating at the renal level with a similar clinical–paraclinical presentation, histopathological characteristics create important differences and can also reveal risk factors shared across tumor types.

Sep 21, 2026

Upload by Oliver