Risk for cancer development in familial Mediterranean fever and associated predisposing factors - an ambidirectional cohort study from the international AIDA Network registries

Sep 21, 2026

Uploaded by Eliana

This original research reports cancer risk in familial Mediterranean fever and examines associated predisposing factors. The study draws on a cohort drawn from the international AIDA Network registries, using an ambidirectional cohort design. It is published as open access in Frontiers in Immunology, with multiple contributing authors and affiliations across medical centers. The work specifies publication, receipt, acceptance, citation, and DOI information for traceability.

LanguageEnglish

CategoryResearch & Report

FormatPDF

Pages12

Reading Time30 min

AccessFree to download

Overview

Study design and data source

Cancer risk and associated factors

Publication details and citation

TYPE Original Research PUBLISHED 10 May 2024 DOI 10.3389/fimmu.2024.1397890 OPEN ACCESS EDITED BY Ozgur Kasapcopur, Istanbul University-Cerrahpasa, Türkiye REVIEWED BY Sezgin Sahin, Istanbul University-Cerrahpasa, Türkiye Oya Koker, Istanbul University, Türkiye *CORRESPONDENCE Luca Cantarini [cantariniluca@hotmail.com](cantariniluca@hotmail.com) †These authors have contributed equally to this work RECEIVED 08 March 2024 ACCEPTED 22 April 2024 PUBLISHED 10 May 2024 CITATION Vitale A, Caggiano V, Tufan A, Ragab G, Batu ED, Portincasa P, Aragona E, Sota J, Conti G, De Paulis A, Rigante D, Olivieri AN, ahin A, La Torre F, Lopalco G, Cattalini M, Maggio MC, Insalaco A, Sﬁkakis PP, Verrecchia E, Yildirim D, Kucuk H, Kardas RC, Laymouna AH, Ghanema M, Saad MA, Sener S, Ercan Emreol H, Ozen S, Jaber N, Khalil M, Di Ciaula A, Gaggiano C, Malizia G, Affronti A, Patroniti S, Romeo M, Sbalchiero J, Della Casa F, Mormile I, Silvaroli S, Gicchino MF, C¸elik NC¸, Tarsia M, Karamanakos A, Hern´andez-Rodrguez J, Parronchi P, Opris-Belinski D, Barone P, Recke A, Costi S, Sfriso P, Giardini HAM, Gentileschi S, Wiesik-Szewczyk E, Vasi I, Loconte R, Jahnz-Ro´z˙yk K, Martn-Nares E, Torres-Ruiz J, Cauli A, Conforti A, Emmi G, Li Gobbi F, Biasi GR, Terribili R, Ruscitti P, Del Giudice E, Tharwat S, Brucato AL, Ogunjimi B, Hinojosa-Azaola A, Balistreri A, Fabiani C, Frediani B and Cantarini L (2024) Risk for cancer development in familial Mediterranean fever and associated predisposing factors: anambidirectional cohort study from the international AIDA Network registries. Front. Immunol. 15:1397890 . doi: 10.3389/fimmu.2024.1397890 Risk for cancer development in familial Mediterranean fever and associated predisposing factors: an ambidirectional cohort study from the international AIDA Network registries Antonio Vitale 1,2†, Valeria Caggiano 1,2†, Abdurrahman Tufan 3, Gaafar Ragab 4,5, Ezgi Deniz Batu 6, Piero Portincasa 7, Emma Aragona 8, Jurgen Sota 1,2, Giovanni Conti 9, Amato De Paulis 10,11, Donato Rigante 12,13, Alma Nunzia Olivieri 14, Ali S¸ahin 15, Francesco La Torre 16, Giuseppe Lopalco 17, Marco Cattalini 18, Maria Cristina Maggio 19, Antonella Insalaco 20, Petros P. Sﬁkakis21, Elena Verrecchia 13,22, Derya Yildirim 3, Hamit Kucuk 3, Riza Can Kardas 3, Ahmed Hatem Laymouna 4, Mahmoud Ghanema 4, Moustafa Ali Saad 4, Seher Sener 6, Hulya Ercan Emreol 6, Seza Ozen 6, Nour Jaber 7, Mohamad Khalil 7, Agostino Di Ciaula 7, Carla Gaggiano 1,2, Giuseppe Malizia 8, Andrea Affronti 8, Serena Patroniti 9, Meri Romeo 9, Jessica Sbalchiero 1,2, Francesca Della Casa 10, Ilaria Mormile 10, Sara Silvaroli 23, Maria Francesca Gicchino 14, Nee C¸abuk C¸elik 15, Maria Tarsia 2,24, Anastasios Karamanakos 25, Jos´e Hern´andez-Rodr ´ıguez 26, Paola Parronchi 27, Daniela Opris-Belinski 28, Patrizia Barone 29, Andreas Recke 30,31, Stefania Costi 32, Paolo Sfriso 33, Henrique A. Mayrink Giardini 34, Stefano Gentileschi 1,2, Ewa Wiesik-Szewczyk 35, Ibrahim Vasi 3, Roberta Loconte 16, Karina Jahnz-Ro´ ˙zyk 35, Eduardo Mart ´ın-Nares 36, Jiram Torres-Ruiz 36, Alberto Cauli 37, Alessandro Conforti 38, Giacomo Emmi 39,40, Francesca Li Gobbi 41, Giovanni Rosario Biasi 1,2, Riccardo Terribili 1,2, Piero Ruscitti 42, Emanuela Del Giudice 43, Samar Tharwat 44,45, Antonio Luca Brucato 46, Benson Ogunjimi 47,48,49,50, Andrea Hinojosa-Azaola 36, Alberto Balistreri 51, Claudia Fabiani 2,52, Bruno Frediani 1,2 and Luca Cantarini 1,2* 1 Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinﬂammatory Diseases and Behet ’s Disease Clinic, University of Siena, Siena, Italy, 2Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeﬁciency, Autoinﬂammatory and Autoimmune Diseases (RITA) Center], Siena, Italy, 3Gazi University Hospital, Department of Internal Medicine, Division of Rheumatology, Ankara, Türkiye, 4 Internal Medicine Department, Rheum

FAQs

What condition is studied regarding cancer development risk?

Familial Mediterranean fever is the primary condition assessed for risk of cancer development.

What dataset supports the study findings?

The study uses registries from the international AIDA Network.

How is the cohort study structured?

The research is described as an ambidirectional cohort study.

Sep 21, 2026

Uploaded by Eliana