Recent Advancements, Limitations, and Future Perspectives of Personalized Medicine in Colon Cancer Treatment - Review

Sep 24, 2026

Uploaded by Margaret

Due to colon cancer heterogeneity, surgery, chemotherapy, and radiation do not work for all patients. The review focuses on personalized medicine by incorporating the genomic profile and process-related biomarkers together with patient personal history. It evaluates genetic, transcriptomic, and epigenetic features to determine optimal therapeutic strategies and diagnostic testing based on targeted therapy responses to specific genetic variations. It also reviews signaling pathways and genetic/epigenetic alterations, current personalized options, and future integration challenges worldwide.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages21

Reading Time53 min

AccessFree to download

Abstract

Keywords

Introduction

Authors and Affiliations

Abbreviations

Recent Advancements, Limitations, and Future Perspectives of the use of Personalized Medicine in Treatment of Colon Cancer Amit Dey, MSc 1,\#, Abhijit Mitra, MPharm 1,\#, Surajit Pathak, PhD 1, Suhanya Prasad, PhD2, Alexander Sun Zhang, MD3, Hong Zhang, PhD4, Xiao-Feng Sun, PhD5, and Antara Banerjee, PhD 1 Technology in Cancer Research & Treatment Volume 22: 1-21 © The Author(s) 2023 Article reuse guidelines: [sagepub.com/journals-permissions](sagepub.com/journals-permissions)[ ](sagepub.com/journals-permissions)[DOI: 10.1177/15330338231178403](DOI: 10.1177/15330338231178403)[ ](DOI: 10.1177/15330338231178403)[journals.sagepub.com/home/tct](journals.sagepub.com/home/tct) Abstract Due to the heterogeneity of colon cancer, surgery, chemotherapy, and radiation are ineffective in all cases. The genomic proﬁle and biomarkers associated with the process are considered in personalized medicine, along with the patient’s personal history. It is based on the response of the targeted therapies to speciﬁc genetic variations. The patient’s genetic transcriptomic and epigenetic features are evaluated, and the best therapeutic approach and diagnostic testing are identiﬁed through personalized medicine. This review aims to summarize all the necessary, updated information on colon cancer related to personalized medicine. Personalized medicine is gaining prominence as generalized treatments are ﬁnding it challenging to contain colon cancer cases which currently rank fourth among global cancer incidence while being the ﬁfth largest in total death cases worldwide. In personalized therapy, patients are grouped into speciﬁc categories, and the best therapeutic approach is chosen based on evaluating their molecular features. Various personalized strategies are currently being explored in the treatment of colon cancer involving immunotherapy, phytochemicals, and other biomarker-speciﬁc targeted therapies. However, signiﬁcant challenges must be overcome to integrate personalized medicine into healthcare systems completely. We look at the various signaling pathways and genetic and epigenetic alterations associated with colon cancer to understand and identify biomarkers useful in targeted therapy. The current personalized therapies available in colon cancer treatment and the strategies being explored to improve the existing methods are discussed. This review highlights the advantages and limitations of personalized medicine in colon cancer therapy. The current scenario of personalized medicine in developed countries and the challenges faced in middle-and low-income countries are also summarized. Finally, we discuss the future perspectives of personalized medicine in colon cancer and how it could be integrated into the healthcare systems. Keywords colon cancer, personalized treatment, precision medicine, targeted therapy, immunotherapy 1 Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Chettinad Hospital and Research Institute, Chennai, India 2 Department of Medical Microbiology and Nanobiomedical Engineering, Medical University of Bialystok, Białystok, Poland 3 Department of Oncology-Pathology, Karolinska Institute, Solna, Sweden 4 School of Medicine, Department of Medical Sciences, Orebro University, Örebro, Sweden 5 Department of Oncology and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden \# Authors contributed equally. Corresponding Authors: Xiao-Feng Sun, Department of Oncology and Department of Biomedical and Clinical Sciences, Linköping University, 581 83 Linköping, Sweden. [Email: xiao-feng.sun@liu.se](Email: xiao-feng.sun@liu.se) Antara Banerjee, Department of Medical Biotechnology, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Chettinad Hospital and Research Institute, Kelambakkam, Chennai, Tamil Nadu, 603103, India. Email: [antarabanerjee@care.edu.in](antarabanerjee@care.edu.in) Creative Commons N

FAQs

Why is colon cancer treatment challenging under conventional approaches?

Colon cancer is heterogeneous, so surgery, chemotherapy, and radiation are ineffective across all cases.

How does personalized medicine guide colon cancer therapy in this review?

Personalized medicine uses genomic profiles and biomarkers plus patient history, assessing genetic, transcriptomic, and epigenetic features to match targeted therapies to specific genetic variations.

What limitations and future needs are discussed for implementing personalized medicine?

The review emphasizes significant challenges to fully integrate personalized medicine into healthcare systems, including obstacles faced in middle- and low-income countries, and it outlines future perspectives for integration.

Sep 24, 2026

Uploaded by Margaret