Rapid and Visible Efficacy of a Dermocosmetic in Acne Patients With Fair Skin Phototypes - Results of a Randomized Split-Face Study

Q: What was the study design used to test the dermocosmetic cream?

A randomized, intra-individual split-face study was conducted over 15 days, comparing treatment on one hemi-face versus no treatment on the other.

Q: Which changes in acne lesions were observed with the dermocosmetic at specific days?

Inflammatory lesion counts decreased significantly at Day 8 and Day 15, while non-inflammatory lesion counts decreased significantly at Day 15. Total lesion counts also decreased at Day 8 and Day 15.

Q: How did participants and clinicians evaluate local tolerance and perceived benefit?

Local tolerance was good, and most subjects reported improved skin appearance and reduced visibility of acne lesions.

Sep 29, 2026

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Dermocosmetic cream efficacy kinetics were evaluated in acne patients with fair skin phototypes using a randomized, intra-individual split-face design. Sixteen participants with mild to moderate acne (phototypes II–III) treated one hemi-face with a dermocosmetic cream containing Punicagranatum Pericarp extract, salicylic acid, niacinamide, zinc gluconate, and Aqua Posae Filiformis, while the other hemi-face received no treatment for 15 days. Inflammatory lesions decreased by Day 8 and Day 15, non-inflammatory lesions improved by Day 15, total lesion counts declined, tolerance was good, and most subjects reported visible acne improvement.

LanguageEnglish

CategoryResearch & Report

FormatPDF

Pages5

Reading Time13 min

AccessFree to download

Abstract

Introduction

Material and Methods

Journal of Cosmetic Dermatology ORIGINAL ARTICLE OPEN ACCESS Rapid and Visible Efficacy of a Dermocosmetic in Acne Patients With Fair Skin Phototypes: Results of a Randomized Split-Face Study Catherine Queille-Roussel1 | James Odeimi2 | Margot Broallier2 | Delphine Kerob2 | Jerry Tan3 1CPCAD, CHU l'Archet, Nice, France | 2La Roche-Posay, Laboratoire Dermatologique, France | 3Department of Medicine and Windsor Clinical Research Inc, Western University, Windsor, Canada Correspondence: James Odeimi ([james.odeimi@loreal.com](james.odeimi@loreal.com)) Received: 9 September 2025 | Revised: 12 December 2025 | Accepted: 17 December 2025 The data presented here were presented in a poster communication at the EADV 2026 congress in Paris. Keywords: acne | dermocosmetic | fair skin phototypes | kinetics ABSTRACT Introduction and Objectives: Dermocosmetics have proven their benefit in acne management. However, only very few studies investigated their efficacy kinetics. This study assessed the efficacy kinetics of a dermocosmetic cream (DC) containing Punicagranatum Pericarp extract, Salicylic acid, Niacinamide, Zinc gluconate, and Aqua Posae Filiformis in subjects with acne. Material and Methods: 16 subjects (14 women, 2 men; mean age 29.4 ± 7.7years; phototype II and III) with mild to moderate acne participated in a randomized, intra-individual, split-face study for 15 days. Hemi-faces randomly received DC or remained untreated. Assessments included lesion counts, acne severity, and local tolerance; subjects also rated the perceived benefit of the DC. Efficacy was also evaluated using standardized multi-modality full-face imaging and a mobile connected imaging system. Results: The inflammatory lesion count significantly (p ≤0.05) decreased with DC at Day 8 and Day 15; a significant decrease of the non-inflammatory lesion count was observed at Day 15 (p < 0.01). The total lesion count had significantly (p ≤0.05) decreased with DC at Day 8 and Day 15. Between-side differences were significant (all p ≤0.05) for all lesion types at D15 . Local tolerance was good. Most subjects considered that their skin appearance and the visibility of acne lesions had improved. Conclusion: This exploratory study provides strong evidence on the efficacy kinetics of a DC cream in acne management in subjects with fair skin tones. It shows that early, daily and specific treatment with a targeted DC significantly improves all acne lesions type, as well as acne severity as soon as 15 days. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2026 The Author(s). Journal of Cosmetic Dermatology published by Wiley Periodicals LLC. Journal of Cosmetic Dermatology, 2026; 25:e70641 1 of 5 [https://doi.org/10.1111/jocd.70641](https://doi.org/10.1111/jocd.70641) 1 | Introduction Acne vulgaris is one of the most common chronic inflammatory skin diseases worldwide. While observed across all skin phototypes and predominantly affecting adolescents with nearly 85% experiencing it, acne is increasingly prevalent among adults [1] . If not adequately treated, acne may cause sequelae such as postinflammatory erythema, especially in fair skin phototypes, as well as hyperpigmentation, and scars, that can heavily impact the patient's quality of life [2] . Even though much data about the development of acne from comedones to papules, pustules, and scars is available from the literature, there is only a paucity of information available about acne lesion lifecycle when being treated or remaining untreated [3] . A key objective in acne treatment is to enhance patient adherence, which can be improved by simplifying treatment regimensto manage existing lesions, prevent permanent marks, and minimize recurrence. While current topical pharmacological acne treatments are effective, their onset of acti

FAQs

What was the study design used to test the dermocosmetic cream?

A randomized, intra-individual split-face study was conducted over 15 days, comparing treatment on one hemi-face versus no treatment on the other.

Which changes in acne lesions were observed with the dermocosmetic at specific days?

Inflammatory lesion counts decreased significantly at Day 8 and Day 15, while non-inflammatory lesion counts decreased significantly at Day 15. Total lesion counts also decreased at Day 8 and Day 15.

How did participants and clinicians evaluate local tolerance and perceived benefit?

Local tolerance was good, and most subjects reported improved skin appearance and reduced visibility of acne lesions.

Sep 29, 2026

Upload by Jake