Radical Trachelectomy Using A Titanium-Nickelide Metal Tricotage Implant to Preserve Fertility in Cervical Cancer Patients

Sep 23, 2026

Cervical cancer in women remains a major cause of morbidity and mortality, and standard early-stage surgery can achieve good oncological control while irreversibly reducing fertility. This study assessed a titanium-nickelide shape-memory metal-ceramic implant designed for uterine closure and strengthening the utero-vaginal anastomosis zone during radical trachelectomy. In 168 patients, fertility outcomes were evaluated after organ-preserving treatment, including pregnancy events, live births, miscarriage timing, menstrual function, follow-up relapse patterns, and overall reproductive results without compromising cancer effectiveness.

LanguageEnglish

CategoryHealthcare

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Short Communications | Editorial Proc | ess: Submission:03/09/2025 Acceptance:12/20/2025 Published:12/27/2025 | | --- | --- | Radical Trachelectomy Using A Titanium-Nickelide Metal Tricotage Implant to Preserve Fertility in Cervical Cancer Patients Michael Krylyshkin 1, Alexander Chernyakov2, Olga Dil 1, Julia Truschuk2, Ekaterina Marchenko3, Svetlana Tamkovich1 *, Alyona Chernyshovа1,4 Abstract Objective: Among malignant neoplasms of the female reproductive system, cervical cancer traditionally occupies a leading position in terms of both morbidity and mortality. Traditional surgical treatment of early-stage cervical cancer leads to satisfactory oncological results, but irreversibly reduces the fertility in this category of patients. The aim of this work was to evaluate the applicability of a metal-ceramic implant with shape memory made of titanium nickelide for the purpose of forming uterine closure and strengthening the anastomosis zone. Methods: A total of 168 untreated patients with cervical cancer underwent radical trachelectomy with reinforcement of the utero-vaginal anastomosis using a titanium-nickelide shape memory implant. The fertility of women after organ-preserving treatment was evaluated. Thirty-nine pregnancies were registered. Results: Currently, 28 healthy children have been born. Two patients gave birth twice, one woman gave birth to twins. In addition, 2 miscarriages were registered at 7 and 19 weeks, 7 patients terminated pregnancy for social reasons at early stages, 2 patients are currently pregnant, at 24 and 32 weeks. The median follow-up for this category of patients is 89±9.6 months. Eight relapses were registered at various followup periods with the localization of the relapse mainly in the area of the anastomosis and iliac vessels. Analysis of menstrual function showed that the duration of the menstrual cycle after surgical treatment in the volume of radical trachelectomy was 29±4.7 days and did not differ significantly from the indicators before the operation. The duration of menstruation also did not differ significantly before and after surgical treatment. Conclusion: Improvement of the method of organ-preserving surgical treatment by radical trachelectomy with the formation of the uterine locking apparatus using titanium-nickelide metal tricotage contributes to the improvement of reproductive results without compromising oncological effectiveness. Keywords: Cervical cancer-radical trachelectomy-titanium-nickelide metal tricotage implant-fertility Asian Pac J Cancer Prev, 26 (12), 4265-4268 Introduction Malignant neoplasms of the organs of the female reproductive system have the largest share (more than 40%) in the structure of oncologic pathology in women [1, 2] . Cervical cancer traditionally occupies the leading position in terms of morbidity, second only to breast cancer and uterine body cancer [2, 3] . In 2023, 15986 new verified cases of cervical cancer were registered in the Russian Federation. The average age of cervical cancer patients is 52 years, however, in recent years there has been an increasing prevalence of this pathology among women under 35 years of age. This trend is characteristic not only for Russia, but also for the world [2, 3] . These circumstances explain not only the medical but also the social side of the problem, especially given the widespread use of delayed childbearing in the modern world. All these aspects dictate the need to develop new and improve existing techniques for organ-preserving treatment of invasive cervical cancer [4] . Wide cone cervical resection with cervical scraping isone of them. However, this method of organ-preserving treatment has a significant limitation, namely FIGO stage IA1. Thus, patients with deeper invasion of cervical cancer have long been forced to receive surgical treatment in the volume of uterine extirpation with appendages (or without appendages), which, along with the radicality of the treatment and satisfa

FAQs

What was the objective of the study?

To evaluate the applicability of a titanium-nickelide metal tricotage implant for uterine closure and strengthening the utero-vaginal anastomosis zone in cervical cancer patients, with the goal of preserving fertility.

How was the implant used in the surgical method?

Radical trachelectomy was performed with reinforcement of the utero-vaginal anastomosis using the titanium-nickelide shape memory implant.

What fertility and follow-up outcomes were reported?

Thirty-nine pregnancies were registered, with 28 healthy children born at the time of reporting and additional events including twins and miscarriages at 7 and 19 weeks; the median follow-up was 89±9.6 months and eight relapses were recorded mainly around the anastomosis and iliac vessels.

Sep 23, 2026

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