Preferred surgical strategies for bladder diverticular carcinoma - Study on laparoscopic partial cystectomy

Sep 30, 2026

Uploaded by Theodore

Investigate the safety and efficacy of laparoscopic partial cystectomy for bladder diverticular carcinoma using retrospective clinical data from 12 patients treated at Quanzhou First Hospital Affiliated to Fujian Medical University between January 2016 and May 2023. All patients underwent laparoscopic partial cystectomy and achieved complete procedures without major intraoperative complications. Pathology confirmed bladder urothelial carcinoma with negative surgical margins in all cases, followed by regular intravesical instillation chemotherapy and selected systemic or intra-arterial adjuvant chemotherapy. Over a 16–49 month median follow-up, 11 patients remained recurrence-free and 1 developed recurrence managed with TURBT and adjuvant radiotherapy. Results support laparoscopic partial cystectomy as a safe and effective option, while larger multicenter studies are needed.

LanguageEnglish

CategoryHealthcare

FormatPDF

Pages9

Reading Time23 min

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Introduction

Materials and methods

Patients and treatment overview

Surgical technique and operative management

[www. nature.com/scientificreports](www. nature.com/scientificreports) OPEN Preferred surgical strategies for bladder diverticular carcinoma YanleYe, Qingxia Chen, Zhiyang Huang & Qi Huang􀀍 To investigate the safety and efficacy of laparoscopic partial cystectomy in the treatment of bladder diverticular carcinoma. A retrospective analysis was performed on the clinical data of 12 patients diagnosed with bladder diverticular carcinoma who were treated at Quanzhou First Hospital Affiliated to Fujian Medical University between January 2016 and May 2023. All patients underwent laparoscopic partial cystectomy. The study assessed surgical parameters (e.g., operation time, intraoperative blood loss), pathological findings (tumor grade, stage, surgical margin status), postoperative complications, adjuvant treatment regimens, and long-term follow-up outcomes (tumor recurrence, survival status). All 12 operations were completed successfully without major intraoperative complications. Postoperative pathology confirmed bladder urothelial carcinoma in all cases, with negative surgical margins in all patients. Postoperatively, all patients received regular intravesical instillation chemotherapy. Additionally, 5 patients underwent systemic intravenous chemotherapy, and 1 patient received intra-arterial chemotherapy as adjuvant treatment to reduce the risk of tumor recurrence. The median follow-up duration was 16–49 months. During follow-up, 11 patients remained free of tumor recurrence, while 1 patient developed recurrent bladder cancer at 15 months postoperatively (subsequently managed with transurethral resection of bladder tumor and adjuvant radiotherapy, achieving long-term survival). Laparoscopic partial cystectomy is a safe and effective therapeutic option for bladder diverticular carcinoma, characterized by low postoperative complication rates and favorable tumor control. Larger-sample, multi-center studies with longer follow-up are needed to further validate its long-term prognostic benefits. Keywords Bladder cancer, Bladder diverticular carcinoma, Laparoscopic partial cystectomy Bladder diverticular carcinoma (BDC) is a rare malignant neoplasm arising from the bladder, accounting for approximately 0.8% to 10% of all bladder malignancies in clinical practice1. Owing to the structural characteristics of bladder diverticula—such as a relatively thin muscular layer, incomplete development, or even complete absence of the muscularis propria—tumors within the diverticulum exhibit a higher propensity for invasion or metastasis compared to conventional bladder tumors2. Traditional therapeutic modalities for BDC, including transurethral resection of bladder tumor (TURBT) and radical cystectomy3, have inherent limitations and drawbacks. For instance, TURBT often fails to achieve complete tumor resection due to the anatomical inaccessibility of diverticular lesions, while radical cystectomy is associated with high perioperative morbidity and a significant impact on patients’ quality of life. Thus, the safety and efficacy of these traditional approaches in BDC management remain to be further validated. To explore the safety and efficacy of laparoscopic partial cystectomy (LPC) for the treatment of BDC, we performed a retrospective analysis of 12 patients with BDC who underwent LPC at Quanzhou First Hospital Affiliated to Fujian Medical University between January 2016 and May 2023. This study focused on analyzing tumor features (e.g., grade, stage), diverticular morphology (e.g., size, location), surgical details (e.g., operative time, intraoperative blood loss), postoperative follow-up protocols, and clinical outcomes (e.g., complication rates, recurrence-free survival). The findings are presented as follows. Materials and methods From January 2016 to May 2023, a total of 12 patients with BDC were admitted to Quanzhou First Hospital Affiliated to Fujian Medical University, all of whom underwent LPC. The treatment process is shown

FAQs

What was the main objective of the study?

To evaluate the safety and efficacy of laparoscopic partial cystectomy for treating bladder diverticular carcinoma.

How many patients were included, and what was the study period?

Twelve patients were included, treated between January 2016 and May 2023 at Quanzhou First Hospital Affiliated to Fujian Medical University.

What postoperative outcomes were reported regarding surgical margins and recurrence?

All patients had negative surgical margins, and during follow-up 11 patients remained free of tumor recurrence while 1 developed recurrent bladder cancer at 15 months.

Sep 30, 2026

Uploaded by Theodore