Precancerous cervical lesion and associated factors among HIV-infected women in Ethiopia - systematic review and metaanalysis

Sep 22, 2026

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Despite increasing cervical cancer in Ethiopia, comprehensive evidence is needed to strengthen prevention and control efforts. This systematic review and meta-analysis estimated the pooled prevalence of precancerous cervical lesion and identified associated factors among women living with HIV/AIDS in Ethiopia. Searches were conducted from February 15, 2024 to March 17, 2024 across multiple databases, with quality appraisal using JBI criteria. Heterogeneity was assessed with Cochrane Q and I2, and fixed-effect pooling produced the final estimates.

LanguageEnglish

CategoryResearch & Report

FormatPDF

Pages10

Reading Time25 min

AccessFree to download

Abstract

Background

Methods

Results

Conclusion

Background

Global burden and regional impact

Screening gaps and risk factors

HIV, HPV, and treatment effects

Ferede etal. BMC Cancer (2024) 24:678 BMC Cancer [https://doi.org/10.1186/s12885-024-12462-9](https://doi.org/10.1186/s12885-024-12462-9) SYSTEMATIC REVIEW Open Access Precancerous cervical lesion and associated factors among HIV-infected women in Ethiopia: systematic review and metaanalysis Yeshiwas Ayale Ferede 1*, Worku Chekol Tassew2 and Agerie Mengistie Zeleke3 Abstract Background Despite several preventative and control measures Ethiopia continues to see an increase in cervical cancer. Comprehensive evidence is very important to suggest ministry of health. Therefore, the aim of this study is to estimate the pooled violence of Precancerous Cervical Lesion and to identify associated factors among women living with HIV AIDS in Ethiopia. Methods From February 15, 2024 to March 17, 2024, systematic and methodical search of the literature was conducted using electronic databases such as PubMed, HINARI, Global Health, Scopus, EMBASE, Web of Science, African Journal online (AJOL), and Google Scholar. Quality appraisal was assessed based on Joanna Briggs Institute (JBI) critical appraisal checklist for analytical cross-sectional study using 9 criteria. The Cochrane Q and I2 test statistics were used to verify the heterogeneity of the studies. Using a fixed effect model, the pooled estimate prevalence of precancerous cervical lesion among women living with HIV was calculated. Results After reviewing 9,470 studies, 9 studies involving 2,910 women with HIV were included. The pooled estimate of precancerous cervical cancer among women living with HIV in Ethiopia was 15. 34%(95% CI: 8 . 97, 21 . 72) . Having history of sexual infection (POR = 3 . 12; 95% CI: 1. 38, 7 . 05), having multiple sexual partner (POR = 3 . 14; 95% CI: 2 . 29, 4. 30), and parity greater than two (POR = 4 . 97; 95% CI: 3 . 17, 7 . 78) were identified factors associated with precancerous cervical lesion. Conclusion This study found that about one-six of HIV-positive women developed precancerous cervical lesion. According to this study, there was a substantial correlation between precancerous cervical lesion among HIV-positive women and having history of sexually transmitted infection, having multiple sexual partners, and being multipara. In order to reduce precancerous cervical lesion, FMOH, policy makers, and interested parties should pay particular attention to this issue. *Correspondence: Yeshiwas Ayale Ferede[yeshiwas981@gmail.com](yeshiwas981@gmail.com) 1Department of Reproductive Health, Teda Health Science College, Gondar, Ethiopia 2Department of Medical Nursing, Teda Health Science College, Gondar, Ethiopia 3Department of Clinical Midwifery, Teda Health Science College, Gondar, Ethiopia © The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creativecommons.org/l](http://creativecommons.org/l)icenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ([http://creativecommons.org/publicdomain/zero/1.0/](http://creativecommons.org/publicdomain/zero/1.0/)) applies to the data made available in this article, unless otherwise stated in a credit line to the data. Ferede et al. BMC Cancer (2024) 24:678 Keywords prevalence, cervical lesion, associated fac

FAQs

What is the main objective of the study?

To estimate the pooled prevalence of precancerous cervical lesion and to identify associated factors among HIV-infected women in Ethiopia.

How were studies searched and selected?

The review searched the literature from February 15, 2024 to March 17, 2024 using electronic databases including PubMed, HINARI, Scopus, EMBASE, Web of Science, AJOL, and Google Scholar.

Which factors were associated with precancerous cervical lesion?

The study found significant associations with history of sexual infection, having multiple sexual partners, and parity greater than two.

Sep 22, 2026

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