Potential Anticancer Effects of Isoflavone Prunetin and Prunetin Glycoside on Apoptosis Mechanisms - Review

Sep 21, 2026

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Cancer arises from abnormal differentiation and proliferation that enables uncontrolled growth, and despite current therapies there is no definitive cure and treatments often bring substantial side effects. Apoptosis, a cell-intrinsic programmed death pathway, has emerged as a key framework for regulating cancer progression and therapeutic responses. This review focuses on isoflavones, especially prunetin and the glycoside prunetin glucoside, summarizing their potential anticancer actions through apoptotic mechanisms and related cell-death signaling pathways across diverse cancers.

LanguageEnglish

CategoryResearch & Report

FormatPDF

Pages15

Reading Time38 min

AccessFree to download

Introduction

Cancer mechanisms and treatment limitations

Natural bioactive compounds and apoptosis

Flavonoids and isoflavones: biological background

Review Scope

Prunetin and prunetin glucoside via apoptotic pathways

Review Potential Anticancer Effects of Isoflavone Prunetin and Prunetin Glycoside on Apoptosis Mechanisms Se Hyo Jeong 1, Hun Hwan Kim 1, Min Yeong Park 1, Pritam Bhangwan Bhosale 1, Abuyaseer Abusaliya 1, Kwang Hyun Hwang 2, Yeon Gyu Moon 2, Jeong Doo Heo 3, Je Kyung Seong 4, Meejung Ahn 5, Kwang Il Park 1, Chung Kil Won 1 and Gon Sup Kim 1, * Citation: Jeong, S.H.; Kim, H.H.; Park, M.Y.; Bhosale, P.B.; Abusaliya, A.; Hwang, K.H.; Moon, Y.G.; Heo, J.D.; Seong, J.K.; Ahn, M.; et al. Potential Anticancer Effects of Isoflavone Prunetin and Prunetin Glycoside on Apoptosis Mechanisms. Int. J. Mol. Sci. 2024, 25, 11713. [https://doi.org/](https://doi.org/)[ ](https://doi.org/)[10.3390/ijms252111713](10.3390/ijms252111713) Academic Editors: Simona Serini and Gabriella Calviello Received: 10 October 2024 Revised: 24 October 2024 Accepted: 28 October 2024 Published: 31 October 2024 Copyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) . 1 Research Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea; [tpgy123@gmail.com](tpgy123@gmail.com) (S.H.J.) 2 Biological Resources Research Group, Gyeongnam Department of Environment Toxicology and Chemistry, Korea Institute of Toxicology, 17 Jegok-gil, Jinju 52834, Republic of Korea 3 Korea Institute of Toxicology, 141, Gajeong-ro, Yuseong-gu, Daejeon 35345, Republic of Korea 4 Laboratory of Developmental Biology and Genomics, BK21 PLUS Program for Creative Veterinary Science Research, Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea 5 Department of Animal Science, College of Life Science, Sangji University, Wonju 26339, Republic of Korea * Correspondence: [gonskim@gnu.ac.kr](gonskim@gnu.ac.kr) Abstract: Cancer is a deadly disease caused by cells that deviate from the normal differentiation and proliferation behaviors and continue to multiply. There is still no definitive cure, and many side effects occur even after treatment. However, apoptosis, one of the programs imprinted on cells, is becoming an important concept in controlling cancer. Flavonoids are polyphenolic compounds found in plants, are naturally bioactive compounds, have been studied for their anticancer effects, and have fewer side effects than chemical treatments. Isoflavones are phytoestrogens belonging to the flavonoid family, and this review discusses in depth the potential anticancer effects of prunetin, one of the many flavonoid families, via the apoptotic mechanism. In addition, a glycoside called prunetin glucoside has been investigated for its anticancer effects through apoptotic mechanisms. The primary intention of this review is to identify the effects of prunetin and its glycoside, prunetinglucoside, on cell death signaling pathways in various cancers to enhance the potential anticancer effects of these natural compounds. Keywords: anticancer; apoptosis; isoflavone; prunetin glucosides; signaling pathway 1. Introduction A tumor is a mass of cells that develops as a result of abnormal cell deregulation and soon becomes cancerous and invades surrounding tissue [1] . The causes of cancer are varied and include genetic and environmental factors, as well as habits such as smoking, high fat intake, and UV radiation [2] . Although we still have not completely cured these cancers, many natural products are actually being used in combination with chemotherapy drugs to treat them [3] . In particular, natural bioactive compounds such as flavonoids, which are secondary metabolites of plants, have attracted a lot of attention because they are bein

FAQs

What role does apoptosis play in cancer control according to the document?

Apoptosis is described as programmed cell death that is a key concept in regulating cancer. Flavonoids are suggested to target abnormal cancer cells by engaging apoptotic mechanisms and associated signaling pathways.

Which compounds are the focus of this review?

The review centers on the isoflavone prunetin and prunetin glucoside (a glycoside form of prunetin), examining their potential anticancer effects through apoptotic mechanisms.

What is the primary purpose of the review?

The primary intention is to identify how prunetin and its glycoside, prunetin glucoside, affect cell death signaling pathways in various cancers, thereby supporting their potential as anticancer natural compounds.

Sep 21, 2026

Uploaded by Skyler