Plant bioactive compounds driven microRNAs (miRNAs): A potential source and novel strategy targeting gene and cancer therapeutics

Sep 21, 2026

Uploaded by Noah

Cancer remains a leading cause of mortality worldwide, and the need for alternative therapies with fewer adverse effects is urgent. Plant bioactive compounds, long used for cancer treatment, can modulate microRNAs (miRNAs) in cancer cells. This miRNA deregulation can promote apoptosis and suggests miRNA-based cancer gene therapy as a promising strategy to prevent cancer and mitigate chemotherapy-related side effects. The review synthesizes mechanisms and highlights plant bioactive compound–driven miRNAs as potential resources for gene therapy and novel targeting approaches.

LanguageEnglish

CategoryResearch & Report

FormatPDF

Pages19

Reading Time48 min

AccessFree to download

Introduction

Non-coding RNA Research 9 (2024) 1140–1158 Contents lists available at ScienceDirect Non-coding RNA Research journal [homepage:](homepage: www.keaipublishing.com/en/journals/non-coding-rna-research)[ www.keaipublishing.com/en/journals/non-coding-rna-research](homepage: www.keaipublishing.com/en/journals/non-coding-rna-research) | Plant bioactive compounds driven microRNAs (miRNAs): A potential source and novel strategy targeting gene and cancer therapeutics | | | | | --- | --- | --- | --- | | Sahreen Sumairaa , Soundararajan Vijayarathna a , Manisekaran Hemagirria , Mohd Adnan b, Md Imtaiyaz Hassan c , Mitesh Patel d , Reena Gupta e , Shanmugapriyaa , Yeng Chen f, Subash C.
B. Gopinath g , Jagat R. Kanwarh , Sreenivasan Sasidharana, *
a Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, USM, 11800, Pulau Pinang, Malaysia b Department of Biology, College of Science, University of Hail, Hail, P.O. Box 2440, Saudi Arabia
c Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, India
d Research and Development Cell and Department of Biotechnology, Parul Institute of Applied Sciences, Parul University, Vadodara, 391760, Gujarat, Indiae Institute of Pharmaceutical Research, Department. Pharmaceutical Research, GLA University, Mathura, India
f Department of Oral & Craniofacial Sciences, Faculty of Dentistry, University of Malaya, 50603, Kuala Lumpur, Malaysia g Faculty of Chemical Engineering Technology, Universiti Malaysia Perlis, Perlis, Malaysia
h Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), 174001, Bilaspur, Himachal Pradesh, India | | | | | A R T I C L E I N F O | | A B S T R A C T | | | Keywords: Anti-cancer Gene therapy miRNA Apoptosis
Plant bioactive compounds | | Irrespective of medical technology improvements, cancer ranks among the leading causes of mortality worldwide. Although numerous cures and treatments exist, creating alternative cancer therapies with fewer adverse side effects is vital. Since ancient times, plant bioactive compounds have already been used as a remedy to heal cancer. These plant bioactive compounds and their anticancer activity can also deregulate the microRNAs (miRNAs) in the cancerous cells. Therefore, the deregulation of miRNAs in cancer cells by plant bioactive compounds and the usage of the related miRNA could be a promising approach for cancer cure, mainly to prevent cancer and overcome chemotherapeutic side effect problems. Hence, this review highlights the function of plant bioactive compounds as an anticancer agent through the underlying mechanism that alters the miRNA expression in cancer cells, ultimately leading to apoptosis. Moreover, this review provides insight into using plant bioactive compounds -driven miRNAs as an anticancer agent to develop miRNA-based cancer gene therapy. They can bethe potential resource for gene therapy and novel strategies targeting cancer therapeutics. | | 1. Introduction Cancer, as a multifactorial health situation involving abnormal cell division and genetic mutation, is a deadly disease with a large percentage of recurrence and resistance that affects men, women and even children all over the world [1]. A recent analysis claims that the prevalence of cancer has significantly increased, that in 2020 new reported cancer cases were 19.3 million, with a subsequent 10 million demises. If this rate persists, then by 2040, there will be more than 30 million cases per year, and we can face the cancer epidemic [2]. In normal cells, symmetric and asymmetric cell divisions are proliferation and differentiation processes, respectively, while uncontrolled cell division is considered a primary reason to cause different types of cancer. Comprehensively, uncontrolled proliferation produces genetic instabilities and alterations, transforming malignant cells from normal cells. Mutations in oncogenes, DNA repair ge

FAQs

What role do plant bioactive compound–driven miRNAs play in gene therapy?

The review suggests that plant bioactive compound–driven miRNAs can be used to develop miRNA-based cancer gene therapy. They are described as potential resources and novel strategies targeting gene and cancer therapeutics.

What is the relationship between uncontrolled cell division and cancer described in the introduction?

Cancer is described as involving abnormal cell division and genetic mutation, where uncontrolled proliferation leads to genetic instabilities. These instabilities transform malignant cells from normal cells and are associated with mutations in oncogenes, DNA repair genes, tumor suppressor genes, and related metabolic growth genes.

Sep 21, 2026

Uploaded by Noah